Effect of <i>Capsicum Frutescens</i> Extract, Capsaicin, and Luteolin on Quorum Sensing Regulated Phenotypes

Rivera, Milagros Liseth Castillo; Hassimotto, Neuza Mariko Aymoto; Bueris, Vanessa; Sircili, Marcelo Palma; Almeida, Felipe Alves de; Pinto, Uelinton Manoel

doi:10.1111/1750-3841.14648

Cited by 34 publications

(45 citation statements)

References 51 publications

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“…Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a monoterpene alkaloid, considered the major pungent component in the genus Capsicum. It is characterised by antioxidant, hypotensive and antimicrobial effects (149)(150)(151) . The antimicrobial targets of capsaicin have not been identified yet (149) but it can reduce cell-invasiveness of Streptococcus (cell-invasive group A) in vitro (152) .…”

Section: Terpenesmentioning

confidence: 99%

Single components of botanicals and nature-identical compounds as a non-antibiotic strategy to ameliorate health status and improve performance in poultry and pigs

Rossi¹,

Toschi

Piva

et al. 2020

Nutr. Res. Rev.

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In the current post-antibiotic era, botanicals represent one of the most employed nutritional strategies to sustain antibiotic-free and no-antibiotic-ever production. Botanicals can be classified either as plant extracts, meaning the direct products derived by extraction from the raw plant materials (essential oils (EO) and oleoresins (OR)), or as nature-identical compounds (NIC), such as the chemically synthesised counterparts of the pure bioactive compounds of EO/OR. In the literature, differences between the use of EO/OR or NIC are often unclear, so it is difficult to attribute certain effects to specific bioactive compounds. The aim of the present review was to provide an overview of the effects exerted by botanicals on the health status and growth performance of poultry and pigs, focusing attention on those studies where only NIC were employed or those where the composition of the EO/OR was defined. In particular, phenolic compounds (apigenin, quercetin, curcumin and resveratrol), organosulfur compounds (allicin), terpenes (eugenol, thymol, carvacrol, capsaicin and artemisinin) and aldehydes (cinnamaldehyde and vanillin) were considered. These molecules have different properties such as antimicrobial (including antibacterial, antifungal, antiviral and antiprotozoal), anti-inflammatory, antioxidant, immunomodulatory, as well as the improvement of intestinal morphology and integrity of the intestinal mucosa. The use of NIC allows us to properly combine pure compounds, according to the target to achieve. Thus, they represent a promising non-antibiotic tool to allow better intestinal health and a general health status, thereby leading to improved growth performance.

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Section: Terpenesmentioning

confidence: 99%

Single components of botanicals and nature-identical compounds as a non-antibiotic strategy to ameliorate health status and improve performance in poultry and pigs

Rossi¹,

Toschi

Piva

et al. 2020

Nutr. Res. Rev.

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“…Biofilm formation is a complex virulence mechanism, which requires gene regulation by different components of the QS system. Changes in the expression of the genes related to the QS network or the presence of mutations can reduce the production of this important bacterial virulence factor 1,12,17 . The detection of the presence of the QS genes associated with the phenotypic analysis of biofilm production can help in the evaluation of their regulation.…”

Section: /7mentioning

confidence: 99%

“…Additionally, reports from studies in the literature indicate that similar results were obtained using isolates from patients with chronic infections as these individuals are in an environment favorable for the appearance of random mutations. Further, antibiotic therapy promotes the artificial selection of bacteria for greater drug resistance, primarily in cases where P. aeruginosa infection is present, as the mucopolysaccharide constituting the biofilm hinders drug diffusion through cell layers 1,14,17,26 .…”

Section: /7mentioning

confidence: 99%

“…At high concentrations, these molecules stimulate biofilm production due to the transcription of specific genes. This complex communication mechanism is called quorum sensing (QS) 13,16,17 . QS enables P. aeruginosa to respond to the self-inducting molecules called acyl-homoserine lactones (AHLs) that target the Las and Rhl genes.…”

Section: Introductionmentioning

confidence: 99%

“…Further, the lasI, rhlI, and pqsA genes are responsible for the biosynthesis of the signaling molecules N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL), N-Butyrylhomoserine lactone (BHL), and the Pseudomonas quinolone signal (PQS), respectively. The corresponding receptors for the signaling molecules are LasR, RhlR, and PqsR, respectively, which are involved in the regulation of bacterial virulence and biofilm formation 17,18,19,20 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phenotypic and genotypic analysis of biofilm production by Pseudomonas aeruginosa isolates from infection and colonization samples

Rodrigues

Lima

Sena

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Pseudomonas aeruginosa is an opportunistic pathogen associated with healthcare-related infections, affecting mainly patients with underlying diseases and immunosuppression. This microorganism has several virulence mechanisms that favour its pathogenesis, including the production of biofilm. This study aimed to analyze the phenotypic production of biofilms, the occurrence of quorum sensing (QS) genes, and the clonal profile of clinical isolates of P. aeruginosa from colonized/infected patients in a tertiary hospital in Recife-PE. Methods: We obtained 21 isolates that were classified as infection isolates (II), and 10 colonization isolates (CI). The phenotypic analysis for biofilm production was performed quantitatively. The QS genes were detected by specific PCRs, and the clonal profile was assessed using ERIC-PCR. Results: Of the 31 isolates, 58.1 % (18/31) were biofilm producers, of which 70 % (7/10) were CI and classified as weakly adherent; 52.4 % (11/21) of the II produced biofilms, and were classified as weak (38.1 %, (8/21)), moderate (9.5 %, (2/21)), and strongly adherent (4.8 %, (1/21)). All isolates harbored the QS genes analyzed. In the clonal analysis, 26 distinct genetic profiles were identified, highlighting the presence of a clone in four samples, i.e., one infection isolate, and 3 colonization isolates. Conclusions: The detection of biofilm formation is important in P. aeruginosa in addition to the identification of colonization and infection isolates, especially from complex environments such as ICUs. Further, we define a strategy for monitoring and analyzing P. aeruginosa strains that can potentially cause infections in hospitalized patients.

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Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

Zhang,

Liu,

Guo

et al. 2024

WIREs Nanomed Nanobiotechnol

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The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating bacterial infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due to the slow development of new antibiotics and the increase of bacterial drug resistance. Consequently, developing new a\ntimicrobial strategies and improving antibiotic efficacy to combat bacterial infection has become an urgent priority. The emergence of nanotechnology has revolutionized the traditional antibiotic treatment, presenting new opportunities for refractory bacterial infection. Here we comprehensively review the research progress in nanotechnology‐based antimicrobial drug delivery and highlight diverse platforms designed to target different bacterial resistance mechanisms. We also outline the use of nanotechnology in combining antibiotic therapy with other therapeutic modalities to enhance the therapeutic effectiveness of drug‐resistant bacterial infections. These innovative therapeutic strategies have the potential to enhance bacterial susceptibility and overcome bacterial resistance. Finally, the challenges and prospects for the application of nanomaterial‐based antimicrobial strategies in combating bacterial resistance are discussed.This article is categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

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Effect of Capsicum Frutescens Extract, Capsaicin, and Luteolin on Quorum Sensing Regulated Phenotypes

Cited by 34 publications

References 51 publications

Single components of botanicals and nature-identical compounds as a non-antibiotic strategy to ameliorate health status and improve performance in poultry and pigs

Single components of botanicals and nature-identical compounds as a non-antibiotic strategy to ameliorate health status and improve performance in poultry and pigs

Phenotypic and genotypic analysis of biofilm production by Pseudomonas aeruginosa isolates from infection and colonization samples

Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

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