Effect of<i>Clostridium butyricum</i>on fecal flora in<i>Helicobacter pylori</i>eradication therapy

Shimbo, Izumi; Yamaguchi, Taketo; Odaka, Takeo; Nakajima, Kénichi; Koide, Akinori; Koyama, Hideo; Saisho, Hiromitsu

doi:10.3748/wjg.v11.i47.7520

Cited by 61 publications

(39 citation statements)

References 21 publications

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“…C. butyricum is a butyric acid-producing Gram-positive anaerobe found in the soil and in the intestines of healthy animals and humans. It can prevent diarrhea and constipation in humans (Shimbo et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Consuming fermented distillers' dried grains with solubles (DDGS) feed reveals a shift in the faecal microbiota of growing and fattening pigs using 454 pyrosequencing

Jin

Han

Zhao³

et al. 2017

Journal of Integrative Agriculture

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The objective of this study was to investigate pig fed by Bacillus coagulans-fermented distillers' dried grains with solubles (DDGS) on the faecal microbial composition and diversity using 454 pyrosequencing. Healthy crossbred (Duroc×York-shire×Landrace) growing and fattening pigs (n=48), with an average initial body weight of 65 kg, were divided into two groups (24 replicates per group; four pens per group; six pigs per pen), and given either DDGS feed as the control, or B. coagulans-fermented DDGS feed as the treatment. Faecal samples were collected on day 0, 7, 14, 21, and 28. DNA was extracted, and the V3-V6 region of the 16S rRNA gene was amplified. The fermented DDGS feed affected the relative abundance of bacteria populations at the phylum, genus, and species levels. At the genus level, the consumption of fermented DDGS feed led to higher relative abundances of faecal Prevotella, Lactobacillus, Clostridium, Bifidobacterium, Roseburia, and Bacillus, and lower relative abundances of faecal Escherichia, Ruminococcus, Dialister, unclassified Lachnospiraceae, unclassified Ruminococcaceae, and unclassified Enterobacteriaceae than in the control. At the species level, the consumption of fermented DDGS feed led to higher relative abundances of faecal Prevotella sp., Lactobacillus johnsonii, Lactobacillus fermentum, Lactobacillus mucosae, Lactobacillus reuteri, Clostridium butyricum, Bifidobacterium sp., and Roseburia sp., and lower relative abundances of faecal Prevotella copri, Escherichia coli, Ruminococcus gnavus, Ruminococcus flavefaciens, and Dialister sp. than in the control. Principal coordinates analysis indicated a distinct separation in the faecal microbial communities of pigs that were fed the fermented and unfermented DDGS feed. Fermented DDGS feed significantly increased the average daily gain (ADG) of pigs, and significantly decreased the average daily feed intake (ADFI) of feed and feed/gain (F/G). Thus, our results demonstrate a beneficial shift in the faecal microbiota of pigs consuming fermented DDGS feed, with potential applications in livestock production.

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Section: Discussionmentioning

confidence: 99%

Consuming fermented distillers' dried grains with solubles (DDGS) feed reveals a shift in the faecal microbiota of growing and fattening pigs using 454 pyrosequencing

Jin

Han

Zhao³

et al. 2017

Journal of Integrative Agriculture

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“…Gotteland et al 23 Not combining with triple or quadruple eradication regimens Opekun et al 24 Not combining with triple or quadruple eradication regimens Wang et al 25 Not combining with triple or quadruple eradication regimens Pantoflickova et al 26 Not combining with triple or quadruple eradication regimens Cruchet et al 27 Not combining with triple or quadruple eradication regimens Gotteland et al 28 Not combining with triple or quadruple eradication regimens Shimizu et al 29 Not combining with triple or quadruple eradication regimens Wendakoon et al 30 Not combining with triple or quadruple eradication regimens Sakamoto et al 31 Not combining with triple or quadruple eradication regimens Michetti et al 32 Not combining with triple or quadruple eradication regimens Shimbo et al 33 Not mention eradication rates and side effects Iakovenko et al 34 Published in Russian Wendakoon et al 35 Published in Russian Lykova et al 36 Published in Russian De Francesco et al 37 Combining with double regimen Abayli et al 38 Investigating relation to formation of cholesterol gallstones Linsalata et al 39 Investigating influence on ornithine decarboxylase activity Plummer et al 40 Investigating effects on the intestinal microbiota Madden et al 41 Investigating effects on the intestinal microbiota Favours control Favours probiotic Figure 6. The effect of probiotics supplementation vs. without probiotics on the incidence of epigastic pain.…”

Section: Excluded Studies Reason For Exclusionmentioning

confidence: 99%

Meta‐analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy

Jin

Ran

Shen

et al. 2006

Aliment Pharmacol Ther

230

152

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“…Unlike pathogenic clostridia, such as Clostridium difficile, Clostridium perfringens, and Clostridium botulinum, CBM588 is nonpathogenic and has been used for treatment of human gastrointestinal disease in clinical settings [96,97]. Several reports have revealed that CBM588 has a potentially Fig.…”

Section: Clostridium Butyricum Induces Il-10-producing Macrophagesmentioning

confidence: 99%

A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease

2015

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Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows the identification of microbiota alterations in IBD. Several studies have shown reduced diversity in the gut microbiota of patients with IBD. Advances in gnotobiotic technology have made possible analysis of the role of specific bacterial strains in immune cells in the intestine. Using these techniques, we have shown that Clostridium butyricum as a probiotic induces interleukin-10-producing macrophages in inflamed mucosa via the Toll-like receptor 2/myeloid differentiation primary response gene 88 pathway to prevent acute experimental colitis. In this review, we focus on the new approaches for the role of specific bacterial strains in immunological responses, as well as the potential of bacterial therapy for IBD treatments.

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Effect ofClostridium butyricumon fecal flora inHelicobacter pylorieradication therapy

Abstract: The combined use of CBM reduced the changes in the intestinal flora and decreased the incidence of gastrointestinal side effects.

Cited by 61 publications

References 21 publications

Consuming fermented distillers' dried grains with solubles (DDGS) feed reveals a shift in the faecal microbiota of growing and fattening pigs using 454 pyrosequencing

Consuming fermented distillers' dried grains with solubles (DDGS) feed reveals a shift in the faecal microbiota of growing and fattening pigs using 454 pyrosequencing

Meta‐analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy

A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease

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