Effect of <i>Coriolus versicolor</i> Mycelia Extract on Exercise Performance and Physical Fatigue in Mice

Ho, Ching-Sung; Tung, Yu Tang; Kung, Woon‐Man; Huang, Wen Ching; Leung, Wing Ki; Huang, Chih‐Wei; Wu, June H.

doi:10.7150/ijms.20547

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…A contusion can cause physical damage, and then lead to sarcomeric damage and muscular cell necrosis 18 . Muscle cells release CK into the blood indicating that muscle damage has occurred or is occurring.…”

Section: Resultsmentioning

confidence: 99%

“…The liver, muscles, lungs, kidneys, heart, and fat tissues were removed at the end of the experiment, and fixed in 10% neutral buffered formalin for 24 h before being processed for a histopathologic analysis as we previously described 18 . Tissues were embedded in paraffin and cut into 4-μm-thick slices for morphological and pathological evaluation, then stained with hematoxylin and eosin (H&E) and examined with a light microscope equipped with a CCD camera (BX-51, Olympus, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

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Effects of dextrose prolotherapy on contusion-induced muscle injuries in mice

et al. 2018

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Current treatment options for muscle injuries remain suboptimal and often result in delayed/incomplete recovery of damaged muscles. In this study, the effects of dextrose prolotherapy on inflammation and regeneration of skeletal muscles after a contusion injury were investigated. Mice were separated into five groups, including a normal control (NC), post-injury with no treatment (mass-drop injury, MDI), post-injury with 10% dextrose (MDI + 10% dextrose), post-injury with 20% dextrose (MDI + 20% dextrose), and post-injury with 30% dextrose (MDI + 30% dextrose). The gastrocnemius muscles of the mice were subjected to an MDI, and muscle samples were collected at 7 days post-injury. Results showed the serum creatine kinase (CK), blood urea nitrogen (BUN), creatinine (CREA), and low-density lipoprotein (LDH) of the MDI-alone group were significantly higher than those of the normal control group (p<0.05). However, levels of serum CK, BUN, CREA, and lactate dehydrogenase (LDH) significantly decreased with different concentrations of dextrose. In addition, dextrose suppressed the macrophage response (F4/80 protein decreased) and promoted muscle satellite cell regeneration (desmin protein increased). In conclusion, dextrose prolotherapy can effectively help repair muscles; therefore, it may be one of the methods for clinically treating muscle injuries.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effects of dextrose prolotherapy on contusion-induced muscle injuries in mice

et al. 2018

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“…The grip strength was assessed using a low-force testing system (Model-RX-5, Aikoh Engineering, Nagoya, Japan) for forelimb muscle strength. The details of the method were described in our previous study [19].…”

Section: Methodsmentioning

confidence: 99%

Antifatigue Activity and Exercise Performance of Phenolic-Rich Extracts from Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus

Tung

Lee

et al. 2019

Nutrients

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Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus (CRV) possess a high phenolic compound content with excellent antioxidant activity. Dietary antioxidants can reduce exercise-induced oxidative stress. Consumption of large amounts of phenolic compounds is positively correlated with reduction in exercise-induced muscle damage. Research for natural products to improve exercise capacity, relieve fatigue, and accelerate fatigue alleviation is ongoing. Here, CRV containing a large total phenolic content (13.4 mg/g of CRV) demonstrated antioxidant activity. Ultra-performance liquid chromatography quantification revealed 1.95 ± 0.02 mg of salidroside in 1 g of CRV. In the current study, CRV were administered to mice for five weeks, and the antifatigue effect of CRV was evaluated using the forelimb grip strength test; weight-loaded swimming test; and measurement of fatigue-related biochemical indicators, such as blood lactate, ammonia, glucose, blood urea nitrogen (BUN), and creatine kinase (CK) activity; and muscle and liver glycogen content. The results indicated that in CRV-treated mice, the forelimb grip strength significantly increased; weight-loaded swimming time prolonged; their lactate, ammonia, BUN, and CK activity decreased, and muscle and liver glucose and glycogen content increased compared with the vehicle group. Thus, CRV have antifatigue activity and can increase exercise tolerance.

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“…A low-force testing system (Model-RX-5, Aikoh Engineering, Nagoya, Japan) for forelimb grip strength was used to measure the grip strength. The details have been described previously [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

The Effects of Thiamine Tetrahydrofurfuryl Disulfide on Physiological Adaption and Exercise Performance Improvement

Huang

Hsu

et al. 2018

Nutrients

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Thiamine, named as vitamin B1, is an important cofactor for the critical enzymes regarding to glucose metabolism, like transketolase, pyruvate dehydrogenase, and alpha-ketoglutarate dehydrogenase. The thiamine tetrahydrofurfuryl disulfide (TTFD) is a derivative of thiamine with higher bioavailability and solubility than thiamine and has been widely applied to health maintenance and disease therapy. Higher physical activities are associated with higher thiamine supplements for efficient energy metabolism. Furthermore, the effective dose of TTFD, beneficial to exercise physiological adaption and performance, still be further validated and the safety evaluation were also an important issue to be considered for potential application. ICR (Institute of Cancer Research) strain mice were allocated as 0, 50, 100, and 500 mg/kg dose groups and administrated by oral gavage consecutively for 6 weeks. Physical activities including grip strength and aerobic endurance were measured. Various fatigue-associated biochemical variables such as lactate, glucose, blood urine nitrogen (BUN) or creatine kinase (CK), were also assessed. The levels of liver and muscle glycogen were measured as an indicator of energy storage at the end of the experiment. Toxicity assessments for long-term supplementation were also further evaluated for safety consideration. TTFD supplementation significantly increased the endurance and grip strength and demonstrated beneficial effects on lactate production and clearance rate after an acute exercise challenge. The TTFD supplementation significantly mitigated the BUN and CK indexes after extended exercise and elevated the glycogen content in the liver and muscle tissues. According to body composition, biochemical and histopathological data, daily administration of TTFD for over 6 weeks (subacute toxicity) also demonstrated reasonable safety results for long-term and adequate supplementation. The toxicity of TTFD were also considered as safety for long-term supplementation with indicated doses. Furthermore, the TTDF could be applied to not only the health promotion but also improvement of exercise physiological adaption and the TTFD could be further considered as potential ergogenic aids combined with different nutrient strategy.

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Effect of Coriolus versicolor Mycelia Extract on Exercise Performance and Physical Fatigue in Mice

Cited by 8 publications

References 25 publications

Effects of dextrose prolotherapy on contusion-induced muscle injuries in mice

Effects of dextrose prolotherapy on contusion-induced muscle injuries in mice

Antifatigue Activity and Exercise Performance of Phenolic-Rich Extracts from Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus

The Effects of Thiamine Tetrahydrofurfuryl Disulfide on Physiological Adaption and Exercise Performance Improvement

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