Effect of <i>Echium amoenum</i> Fisch. et Mey a Traditional Iranian Herbal Remedy in an Experimental Model of Acute Pancreatitis

Abed, Alireza; Minaiyan, Mohsen; Ghannadi, Alireza; Mahzouni, Parvin; Babavalian, Mohammad Reza

doi:10.5402/2012/141548

Cited by 17 publications

(10 citation statements)

References 29 publications

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“…reduced amylase and lipase activity, TNF-alpha, MPO activity, and pathological alterations, which are markers of pancreatitis. Action of diazepam on PBRs was already reported as being related to its effects on acute inflammation [20]. This is in accordance with the results obtained by Lazzarini et al which demonstrated that the diazepam was effective to protect against carrageenan-induced acute inflammatory paw edema [11].…”

Section: Discussionsupporting

confidence: 87%

Effect of Diazepam on Severity of Acute Pancreatitis: Possible Involvement of Peripheral Benzodiazepine Receptors

Abed

Minaiyan

Safaei

et al. 2013

ISRN Gastroenterology

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Acute pancreatitis is a lethal inflammatory condition of pancreas with high mortality rate. There is a pressing need for research to explore active agents and novel mechanisms involving in the treatment of pancreatitis. Clinical studies have shown after the initial acinar cell injury plasma levels of pro-inflammatory cytokines are elevated in patients with acute pancreatitis and the degree of cytokine elevation correlates with disease severity. Diazepam may decrease interleukin release from macrophages, suppress neutrophil activities, and exhibit anti-inflammatory effects. So it is expected that in vivo pretreatment of acute pancreatitis with different doses of diazepam can attenuate its severity. Thus, we evaluated the effects of diazepam, intraperitoneally (5, 10, and 20 mg/kg i.p.), intracerebroventricularly (ICV 10 μg), and concurrently with flumazenil (1 mg/kg) on cerulein-induced acute pancreatitis in mice. Interestingly, the pretreatment with diazepam (5 mg/kg i.p.) reduced significantly the inflammatory response of acute pancreatitis by ameliorating pancreatic edema, amylase and lipase serum levels, myeloperoxidase activity, pancreatic TNF-alpha, and pathological alteration compared to control group. Diazepam i.c.v. was ineffective, suggesting that central benzodiazepine receptors have no significant role in this property. These results demonstrate that pretreatment with diazepam exhibits anti-inflammatory property in cerulein-induced acute pancreatitis possibly through peripheral benzodiazepine receptors.

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Section: Discussionsupporting

confidence: 87%

Effect of Diazepam on Severity of Acute Pancreatitis: Possible Involvement of Peripheral Benzodiazepine Receptors

Abed

Minaiyan

Safaei

et al. 2013

ISRN Gastroenterology

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“…The pictures were analyzed for the number, and extent of ulcers by Fiji P software has offered for image processing and analysis. [ 19 ]…”

Section: Methodsmentioning

confidence: 99%

Protective effect of two extracts of Cydonia oblonga miller (Quince) fruits on gastric ulcer induced by indomethacin in rats

2017

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Background:In various studies, Cydonia oblonga Miller (quince) has been reported to have many properties such as antioxidant and anti-ulcerative effects. This study has aimed to investigate the protective effects of quince aqueous extract (QAE) and quince hydroalcoholic extract (QHE) on gastric ulcer caused by indomethacin and the relevant macroscopic, histopathology, and biochemical factors in rats.Methods:Ten groups of male Wistar rats, six in each, were used in this study. These groups included: normal (distilled water), control (distilled water + indomethacin), reference (ranitidine or sucralfate + indomethacin), and test groups (QAE or QHE + indomethacin) treated with three increasing doses (200, 500, and 800 mg/kg). Extracts and drugs were given orally to rats 1 h before injecting the indomethacin (25 mg/kg, intraperitoneally). Six hours later, the abdomen of rats was exposed, its pylorus was legated, gastric acid content was extracted, and its pH and the amount of pepsin secreted were measured by Anson method. Then, histopathology indices, ulcer area, ulcer index, and myeloperoxidase (MPO) activity were measured in gastric mucus.Results:Both extracts of quince were effective to reduce the acidity of stomach and pepsin activity. Compared to control group, the average of enzyme activity of MPO was significantly declined in all treated groups. Control group had the highest level of gastric ulcer indices including severity, area, and index while the evaluated parameters had decreased in all extract treated groups although it seems that QAE was somewhat more effective.Conclusions:Protective effect of QAE and QHE on gastric ulcer was done by undermining offensive factors including decreasing the secretion of gastric acid and pepsin activity and by strengthening the protective factors of gastric mucus including antioxidant capacity.

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“…The extracts significantly reduced the neutrophil migration in cerulein‐induced AP (Conforti et al , ; Minaiyan et al , ). Similarly, E. amoenum protected mice against cerulein‐induced AP by its antioxidant, antiinflammatory and immunomodulatory effects (Abed et al , ). This report warrants for further in detail mechanistic studies to be carried out to assess the pharmacological efficacy of these folks plant of the middle‐east.…”

Section: Herbal Remedies Used For Treating Pancreatitismentioning

confidence: 98%

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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Effect of Echium amoenum Fisch. et Mey a Traditional Iranian Herbal Remedy in an Experimental Model of Acute Pancreatitis

Cited by 17 publications

References 29 publications

Effect of Diazepam on Severity of Acute Pancreatitis: Possible Involvement of Peripheral Benzodiazepine Receptors

Effect of Diazepam on Severity of Acute Pancreatitis: Possible Involvement of Peripheral Benzodiazepine Receptors

Protective effect of two extracts of Cydonia oblonga miller (Quince) fruits on gastric ulcer induced by indomethacin in rats

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

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