2021
DOI: 10.1089/jmf.2020.0024
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Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance

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Cited by 21 publications
(16 citation statements)
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“…It has also been found that the leaf extract of G. inodorum could decrease blood glucose by inhibiting glucose absorption [ 8 , 9 ]. G. sylvestre is the same genus that is popular in India for suppressing glucose absorption and preventing type 2 diabetes mellitus [ 10 , 11 ]. The leaves of this plant also have polyphenols, flavonoids, triterpenoid saponins, anthraquinones, alkaloids, tannin, quinones, and gymnemic acids, which are the major active compounds of G. sylvestre leaf extract [ 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…It has also been found that the leaf extract of G. inodorum could decrease blood glucose by inhibiting glucose absorption [ 8 , 9 ]. G. sylvestre is the same genus that is popular in India for suppressing glucose absorption and preventing type 2 diabetes mellitus [ 10 , 11 ]. The leaves of this plant also have polyphenols, flavonoids, triterpenoid saponins, anthraquinones, alkaloids, tannin, quinones, and gymnemic acids, which are the major active compounds of G. sylvestre leaf extract [ 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…Modern pharmacological studies have found that G. sylvestre leaf, root and stem extracts all have hypoglycemic effect [10][11][12]. Previous studies of this plant afforded that it has broad biological activities for anti-diabetic effect, for example, by suppressing elevated glucose levels in blood, recovering pancreatic beta cells and increasing insulin sensitivity to treat type 2 diabetes mellitus in the earliest stage of disease [13][14][15][16]. The serum levels of GLUT-4, PPAR-γ, adiponectin, and leptin have a positive correlation with insulin sensitivity.…”
Section: Introductionmentioning
confidence: 99%
“…These patients were also subjected to an OGTT before and after the supplement intake. At the end of the study, it has been observed that the GS leaf extract assumption resulted in a significant decrease in HbA 1c values (−0.40%, −10.00%, p = .003) and PPG levels at 2 hr (−23.40 mg/dl, −14.30%, p = .025) after OGTT respect to baseline, thus entailing an increase of insulin sensitivity (Gaytán Martínez et al, 2021 ).…”
Section: Nutraceuticalsmentioning
confidence: 97%