Effect of
            <i>Helicobacter pylori</i>
            Treatment on Unexplained Iron Deficiency Anemia

Tseng, Daniel S.; Li, Dan; Cholleti, Sri M; Wei, Julia; Jodesty, Yves; Pham, Hung-Viet

doi:10.7812/tpp/18-195

Cited by 20 publications

(20 citation statements)

References 21 publications

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“…However, in a recent retrospective study by Daniel et al [16], they found no evidence that H. pylori is involved in causing IDA. IDA is resolved in most subjects regardless of H pylori treatment status.…”

Section: Results Of Previous Studies Have Implicatedmentioning

confidence: 92%

Gastrointestinal Tract Endoscopic Evaluation of Iron Deficiency Anemia Patients without Gastrointestinal Manifestations Tanta University Hospitals Experience

Elmezayen

Hodeib

Enaba

et al. 2021

JAMMR

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Aims: Endoscopic evaluation of symptomless IDA patients and related lesions. Study Design: A Cross-sectional epidemiological study. Place and Duration of Study: The hematology unit of the Internal medicine department in Tanta university hospital, the duration of the study was 6 months from 1 January to 31 June 2019. Methodology: 100 consecutive patients with laboratory base diagnosis of IDA without GI symptoms were involved in the study and their clinical and biochemical variables were recorded. All patients underwent esophagogastroduodenoscopy (EGD) and colonoscopy. Endoscopic findings were documented as the presence/absence of bleeding-related lesions or other causes of IDA. Results: Possible cause of anemia was found in 95% and bleeding related lesions were found in 70% of patients. Upper GIT lesions were found in 70% of patients with 42% bleeding related lesions. Lower GIT lesions were found in 33% of patients with 21% bleeding related lesions. On multivariable logistic regression: old age, low hemoglobin (HB), low serum ferritin, and positive fecal occult blood test (FOBT) were predictive factors for GIT lesions and cause of IDA. Conclusion: Clinical and biochemical markers can predict GI lesions on endoscopy in IDA patients without GI symptoms. A high proportion of upper GI involvement makes EGD an initial endoscopic procedure however, a colonoscopy should be done in old age, and when upper GI lesions don't correlate with the severity of IDA.

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Section: Results Of Previous Studies Have Implicatedmentioning

confidence: 92%

Gastrointestinal Tract Endoscopic Evaluation of Iron Deficiency Anemia Patients without Gastrointestinal Manifestations Tanta University Hospitals Experience

Elmezayen

Hodeib

Enaba

et al. 2021

JAMMR

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“…Tseng et al 29 conduziram uma coorte com 508 indivíduos da Califórnia com ADF inexplicada. Não houve nenhuma diferença na melhoria dessa condição após o tratamento da infecção por H. pylori, quando acompanhada por até 2 anos em comparação com aqueles que não foram tratados.…”

Section: Resultsunclassified

Relação entre a infecção por Helicobacter pylori e doenças hematológicas: uma revisão integrativa

Soares¹,

Moraes²,

Barbosa³

2022

CBR

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Helicobacter pylori, uma bactéria gram-negativa, desde 1984 vem sendo associada às doenças gástricas. A partir da década de 1990, surgiram crescentes relatos indicando a relação da infecção com manifestações extragástricas. Nesse sentido, o objetivo do estudo foi investigar, através de uma revisão integrativa, as evidências relacionadas à H. pylori e a presença de doenças hematológicas, focando na anemia por deficiência de ferro (ADF) e na púrpura trombocitopênica idiopática (PTI). Bases de dados foram consultadas com as palavras-chave e descritores Helicobacter pylori, Doenças extragástricas, Doenças hematológicas, Anemia ferropriva e Púrpura Trombocitopênica Idiopática, nos idiomas inglês, português e espanhol, combinados com o operador booleano "AND". Após a leitura de 1.964 títulos, 85 artigos atendiam aos critérios de inclusão. Com a exclusão dos artigos duplicados e pela análise dos resumos, 62 trabalhos foram selecionados e lidos na íntegra. Por fim, 27 estudos foram incluídos: 13 relacionados à ADF e 77% deles encontraram associação com H. pylori, e 14 relacionados à PTI, nos quais a relação com a bactéria foi encontrada em 93%. As evidências que associam essas doenças hematológicas com H. pylori são expressivas, portanto, mais estudos são necessários para elucidar os mecanismos relacionados e contribuir para prevenção, diagnóstico e tratamento mais eficazes.

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“…Mwafy et al investigated 150 H pylori ‐positive patients (18‐50 years old) and 150 matched controls for several hematologic parameters, and they found significantly lower levels of iron in infected patients compared to uninfected (71.6 ± 24.8 vs 80.1 ± 20.7 μg/dL) and similar results were obtained for vitamin B12 levels (262.5 ± 100 vs 378.2 ± 160.6 pg/mL) . Nevertheless, Tseng et al, who followed up 508 patients with IDA, did not report any significant difference on hemoglobin levels between those treated or not treated for H pylori after a 2‐year observation but that could also be due to the presence of intestinal metaplasia . Similarly, John et al did not find an association between H pylori infection and IDA; ethnic dissimilarities as well as differences in diagnostic criteria may also possibly explain these discrepancies.…”

Section: Hematologic Diseasesmentioning

confidence: 93%

Review:Helicobacter pyloriand extragastric diseases

2019

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In the last year, many studies have demonstrated a potential role of Helicobacter pylori in the pathogenic mechanisms of different extragastric diseases. While the role of H pylori in idiopathic thrombocytopenic purpura, idiopathic iron deficiency anemia, and vitamin B12 deficiency has already been demonstrated, there is growing evidence of other related conditions, especially cardiovascular, metabolic, and neurologic disorders, including neurodegenerative diseases. A summary of the results of the most relevant studies published over the last year on this attractive topic is presented in this review.

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Effect of Helicobacter pylori Treatment on Unexplained Iron Deficiency Anemia

Cited by 20 publications

References 21 publications

Gastrointestinal Tract Endoscopic Evaluation of Iron Deficiency Anemia Patients without Gastrointestinal Manifestations Tanta University Hospitals Experience

Gastrointestinal Tract Endoscopic Evaluation of Iron Deficiency Anemia Patients without Gastrointestinal Manifestations Tanta University Hospitals Experience

Relação entre a infecção por Helicobacter pylori e doenças hematológicas: uma revisão integrativa

Review:Helicobacter pyloriand extragastric diseases

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