Effect of <i>in ovo</i> feeding of folic acid on the folate metabolism, immune function and epigenetic modification of immune effector molecules of broiler

Li, Shizhao; Zhi, Lin; Li, Yanli; Shen, Jing; Liu, Lei; Yao, Junhu; Yang, Xiaojun

doi:10.1017/s0007114515004511

Cited by 58 publications

(40 citation statements)

References 53 publications

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“…From early gestation to lambing, the increase of IgG in both TW and TR ewes indicated the ewe's immunity was positively affected by dietary FA levels during pregnancy. Results in human (long-term synthetic FA supplementation) [30] and broiler (in ovo injection of FA) [31] also showed FA supplementation was beneficial to immune function. IgM only increased in TR ewes treated with FA addition, the lack of response by TW ewes during gestation remains unclear and is deserving of further research.…”

Section: Discussionmentioning

confidence: 95%

Effect of Dietary Folic Acid Supplementation during Pregnancy on Blood Characteristics and Milk Composition of Ewes

Wang

et al. 2020

Animals

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Simple Summary: Folic acid (FA) plays a critical role in regulating fetal development. Cause of the association between maternal metabolism and fetal development has created interest to study FA's effects on maternal blood metabolism and milk composition. FA was supplemented in the diet of ewes with different litter size during pregnancy and blood parameters, and milk composition was monitored. The results indicated that FA supplementation improved folate metabolism balance during gestation of prolific ewes, and contributed to the ewe's blood metabolism and health. In addition, immune-related compounds in milk were improved with dietary FA supplementation, thus, the newborn lamb should benefit from the improvement in milk quality. Abstract:The objective of the present study was to investigate the dynamic change of serum parameters and milk composition by dietary FA supplementation with ewes with different litter size from mating to lambing. The ewes were divided into six treatments (TW-CON, TW-F16, TW-F32, TR-CON, TR-F16, TR-F32) according to dietary FA levels (control, CON; 16 or 32 mg·kg −1 rumen-protect-FA supplementation, F16 and F32) and litter size (twin born, TW; and triplet born, TR). In serum, the concentration of folate increased linearly with dietary FA supplementation (P < 0.05), regardless of the litter size, they showed a quadratic response to gestation progression (P < 0.05). With dietary FA addition, IGFI-I levels significant increased from late gestation to after lambing (P < 0.05), and linearly increased immunoglobulin during the perinatal period (P < 0.05). In colostrum and milk at d 15, the content of folate, lactoferrin, and IgG were affected positively by FA supplementation (P < 0.05). IgG was higher in the TW group than TR in colostrum (P < 0.05), and lactoferrin in TW was lower than TR in milk of d 15 (P < 0.05). FA supplementation increased protein content in colostrum (P < 0.05), while it had no effect on the fat, lactose, and BUN of colostrum and milk of d 15 (P > 0.05). These results suggest that FA supplementation during gestation could regulate maternal blood metabolism and contribute to milk immune composition.

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Section: Discussionmentioning

confidence: 95%

Effect of Dietary Folic Acid Supplementation during Pregnancy on Blood Characteristics and Milk Composition of Ewes

Wang

et al. 2020

Animals

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“…54 Immunostimulants Late stage Amniotic fluid Immunostimulants have a protective role against salmonella invasion, macrophage and antibody response. 55,56 Vitamin E (15-30 mg/egg) 14th day Amniotic fluid Increased hatchability percentage, immunoglobulins M, G, and A as well as increased feed intake. 57 Nano-copper ( 7th day Air cell Plasma levels of total lipids and cholesterol were decreased in chicks hatched from eggs injected with vitamins compared with those hatched from control eggs.…”

Section: Late and Early Stagementioning

confidence: 99%

In ovodelivery of various biological supplements, vaccines and drugs in poultry: current knowledge

et al. 2019

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The technique of delivering various nutrients, supplements, immunostimulants, vaccines, and drugs via the in ovo route is gaining wide attention among researchers worldwide for boosting production performance, immunity and safeguarding the health of poultry. It involves direct administration of the nutrients and biologics into poultry eggs during the incubation period and before the chicks hatch out. In ovo delivery of nutrients has been found to be more effective than post‐hatch administration in poultry production. The supplementation of feed additives, nutrients, hormones, probiotics, prebiotics, or their combination via in ovo techniques has shown diverse advantages for poultry products, such as improved growth performance and feed conversion efficiency, optimum development of the gastrointestinal tract, enhancing carcass yield, decreased embryo mortality, and enhanced immunity of poultry. In ovo delivery of vaccination has yielded a better response against various poultry pathogens than vaccination after hatch. So, this review has aimed to provide an insight on in ovo technology and its potential applications in poultry production to deliver different nutrients, supplements, beneficial microbes, vaccines, and drugs directly into the developing embryo to achieve an improvement in post‐hatch growth, immunity, and health of poultry. © 2019 Society of Chemical Industry

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“…Unlike the mammal, chick embryo development is out of the strong control of maternal effects during hatching, which provides a good experimental model to study the effects of early nutrient intervention during this neonatal period [6,7]. With the in ovo method, it is also practicable to identify the specific effects of nutrients supply on neonatal growth, organ development and microbiota colonization in a relative separate system [8].…”

Section: Introductionmentioning

confidence: 99%

Dynamic alterations in early intestinal development, microbiota and metabolome induced by in ovo feeding of L-arginine in a layer chick model

Dai¹,

Wu²,

Zhang³

et al. 2020

J Animal Sci Biotechnol

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Background: Prenatal nutrition is crucial for embryonic development and neonatal growth, and has the potential to be a main determinant of lifelong health. In the present study, we used a layer chick model to investigate the effects of in ovo feeding (IOF) of L-arginine (Arg) on growth, intestinal development, intestinal microbiota and metabolism. The treatments included the non-injected control, saline-injected control, and saline containing 2, 6, or 10 mg Arg groups. Results: IOF Arg increased early intestinal index and villus height, and enhanced uptake of residual yolk lipid, contributing to subsequent improvement in the early growth performance of chicks. Prenatal Arg supplementation also increased the early microbial α-diversity, the relative abundance of Lactobacillales and Clostridiales, and decreased the relative abundance of Proteobacteria of cecum in chicks. Furthermore, the shift of cecal microbiota composition and the colonization of potential probiotics were accelerated by IOF of Arg. Simultaneously, metabolomics showed that metabolisms of galactose, taurine-conjugated bile acids and lipids were modulated to direct more energy and nutrients towards rapid growth of intestine at the beginning of post-hatch when embryos received IOF of Arg. Conclusions: Prenatal Arg supplementation showed beneficial effects on the early intestinal development, cecal microbiota and host metabolism of layer chicks, contributing to subsequent improvement in the early growth performance. These findings provide new insight into the role of IOF of Arg in the establishment of the gut microbiota of newly-hatched layer chicks, and can expand our fundamental knowledge about prenatal nutrition, early bacterial colonization and intestinal development in neonate.

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Effect of in ovo feeding of folic acid on the folate metabolism, immune function and epigenetic modification of immune effector molecules of broiler

Cited by 58 publications

References 53 publications

Effect of Dietary Folic Acid Supplementation during Pregnancy on Blood Characteristics and Milk Composition of Ewes

Effect of Dietary Folic Acid Supplementation during Pregnancy on Blood Characteristics and Milk Composition of Ewes

In ovodelivery of various biological supplements, vaccines and drugs in poultry: current knowledge

Dynamic alterations in early intestinal development, microbiota and metabolome induced by in ovo feeding of L-arginine in a layer chick model

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