Effect of <i>Lactobacillus plantarum</i> BFS1243 on a female frailty model induced by fecal microbiota transplantation in germ-free mice

Dong, Sashuang; Zeng, Qi; He, Weimin; Cheng, Wei; Zhang, Ling; Zhong, Ruimin; He, Wen; Fang, Xiang; Wei, Hong

doi:10.1039/d3fo05282f

Cited by 2 publications

References 61 publications

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Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China

Zhong,

Yang,

Liu

et al. 2024

Front. Microbiol.

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IntroductionGut microbiota (GM) has been implicated in gestational diabetes mellitus (GDM), yet longitudinal changes across trimesters remain insufficiently explored.MethodsThis nested cohort study aimed to investigate GM alterations before 24 weeks of gestation and their association with GDM. Ninety-three Chinese participants provided fecal samples during the first and second trimesters. Based on oral glucose tolerance tests, 11 participants were classified as GDM, and 82 as non-diabetic (ND). Using 16S rRNA sequencing, we analyzed both cross-sectional and longitudinal differences in GM structure between those two groups.ResultsIn the first trimester, GDM group exhibited lower levels of Bacteroides_H and Acetatifactor compared to ND group (p < 0.05). In the second trimester, GDM individuals showed increased abundance of Fusobacteriota and Firmicutes_D, and genera including Fusobacterium_A and Fournierella, while Anaerotruncus and others decreased (P<0.05). Inflammation-associated genera like Gemmiger_A_73129 and Enterocloster increased, while Megamonas decreased in overweight or obese GDM women, which was not identified in normal-weight women. The ratios of relative abundance of genera Streptococcus, Enterocloster, and Collinsella exceeded 1.5 in the GDM group, particularly in overweight or obese individuals. Inflammatory pathways related to African trypanosomiasis and Staphylococcus aureus infection were predicted to be up-regulated in overweight or obese GDM individuals but not in normal-weight GDM women.DiscussionThis study suggests that GM of women with GDM undergoes significant alterations between the first and second trimesters, potentially linked to inflammation, with more pronounced changes observed in overweight or obese individuals.

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Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China

Zhong,

Yang,

Liu

et al. 2024

Front. Microbiol.

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Dietary Modulation of the Gut Microbiome and Its Impact on Host Health

Dutta,

Mohapatra,

Mishra

et al. 2024

Advances in Medical Diagnosis, Treatment, and Care

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Gut microbiota is highly influenced by dietary consumption. Lifestyle choices affect the microbial ecology, which in turn affects gut homeostasis. Altering host physiology may be possible with nutrition-induced alterations in gut microbiota triggering several diseases. Hence, the aggregate of food processing, the presence of prebiotic and probiotic, and the gut microbiota impact the host's immune system and health. Understanding these factors might justify individualized dietary therapies meant to prevent dysbiosis and help avert severe chronic diseases. This chapter describes the pathways involved in the metabolism of fat, protein, and carbohydrates in addition to the ways they communicate and control body systems. It also discusses how nutrition affects the microbiota and how dietary microbiome interactions may affect the development and progression of disease. It also spotlights on the features to preserve intestinal wellness.

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Effect of Lactobacillus plantarum BFS1243 on a female frailty model induced by fecal microbiota transplantation in germ-free mice

Abstract: Frailty, a complex geriatric syndrome, significantly impedes the goal of achieving 'healthy aging'. Increasing evidences suggest a connection between gut microbiota, systemic inflammation, and disease. However, it remains to be...

Cited by 2 publications

References 61 publications

Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China

Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China

Dietary Modulation of the Gut Microbiome and Its Impact on Host Health

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