Effect of Lactobacillus plantarum P‐8 on lipid metabolism in hyperlipidemic rat model

Abstract

Probiotics have been reported to play an important role in the prevention of metabolic disorders. We recently identified a novel probiotic strain Lactobacillus plantarum (L. plantarum) P-8. The objective of this study was to determine the effects of L. plantarum P-8 on lipid metabolism of rats fed with high fat diet. All experimental rats were divided into three groups: control group, model group, and L. plantarum P-8 group. Changes in serum lipid levels, hepatic lipid deposition, serum oxidative stress-related parameters, activities of liver function marker enzymes, organ indices, gut microflora, and fecal lipids were assessed. Compared with model group, L. plantarum P-8 exhibited hypolipidemic effects by lowering serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol levels, accompanied with elevation of high-density lipoprotein cholesterol level. L. plantarum P-8 also exerted beneficial effects against high-fat diet-induced oxidative stress, curtailed the accumulation of liver lipids and protected healthy liver function. Moreover, L. plantarum P-8 was able to regulate intestinal bacteria and enhance the fecal excretion of TC, TG, and bile acid. These findings indicate that L. plantarum P-8 may represent a potential therapeutic agent for controlling hyperlipidemia.

Antihyperlipidaemic effect of microencapsulated Lactobacillus plantarum LIP‐1 on hyperlipidaemic rats

“…1). This confirms the results of Bao et al 24 who showed that L. plantarum P-8 was also effective in preventing liver injury based on results from ALT and AST analysis.…”

“…4,22 Meanwhile, our previous studies have shown that some gut bacteria (namely Bacteroides, Clostridium, Eubacterium, Escherichia, and Lactobacillus) were increased in rats given LIP-1 cells, which were known to deconjugate bile salts in the gut and enhance CHO excretion. 23 Bao et al 24 showed similar results for the influence of L. plantarum P-8 on lipometabolism in humans. Dvir et al 25 also found a CHOlowering potential for red microalga, mainly caused by enhanced excretion.…”

Effect of microencapsulated Lactobacillus plantarum LIP-1 on cholesterol metabolism in hyperlipidaemic rats

“…1). This confirms the results of Bao et al [22] who showed that L. plantarum P-8 was also effective on the prevention of liver injury based on results from ALT and AST analysis.…”

“…Meanwhile, our previous studies have shown that some gut bacteria (namely Bacteroides, Clostridium, Eubacterium, Escherichia and Lactobacillus) were increased in rats given LIP-1 cells, which were known to deconjugate bile salts in the gut and enhance cholesterol excretion [21]. Bao et al [22] showed similar results for the influence of L. plantarum P-8 on lipometabolism in humans. Dvir et al [23] also found a cholesterol-lowering potential for red microalga, mainly caused by enhanced excretion.…”

Significant effect of Ca2+on improving the heat resistance of lactic acid bacteria

“…through the basic local alignment search tool ( ncbi ‐ blast ). Lactobacillus casei Zhang (LCZ), Lactobacillus plantarum P8 (LP) and S. thermophilus ND03 (ST) were provided by the Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, China (Sun et al ., ; Bao et al ., ; Wang et al ., ).…”