Effect of<i>Melothria maderaspatana</i>Leaf-Tea Consumption on Blood Pressure, Lipid Profile, Anthropometry, Fibrinogen, Bilirubin, and Albumin Levels in Patients with Hypertension

Raja, Boobalan; Kaviarasan, Kuppusamy; Arjunan, Mangalam Muthu; Pugalendi, Kodukkur Viswanathan

doi:10.1089/acm.2006.5373

Cited by 12 publications

(8 citation statements)

References 36 publications

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“…M. maderaspatana has been reported to diminish BP in DOCA-salt hypertensive rats (Veeramani et al, 2011 , 2012 ; Table 2 ) as well as in hypertensive humans (Raja et al, 2007 ). Indeed, individuals with mild hypertension that consumed melon-gubat tea (4% w/v leaf powder) for 45 days showed a significant decrease in both SBP and DBP (23.8 and 15.5 mm Hg, respectively) (Raja et al, 2007 ; Table 6 ). It has also shown a positive effect on eNOS (Veeramani et al, 2012 ) and cellular antioxidants (Veeramani et al, 2011 ) levels in DOCA-salt induced hypertension (Table 1 ).…”

Section: Herbs and Spices Less Commonly Used For Treatment Of Hypertementioning

confidence: 99%

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

2016

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Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very broad range of plants. Globally, the use of herbal therapies to treat and manage cardiovascular disease (CVD) is on the rise. This is the second part of our comprehensive review where we discuss the mechanisms of plants and herbs used for the treatment and management of high blood pressure. Similar to the first part, PubMed and ScienceDirect databases were utilized, and the following keywords and phrases were used as inclusion criteria: hypertension, high blood pressure, herbal medicine, complementary and alternative medicine, endothelial cells, nitric oxide (NO), vascular smooth muscle cell (VSMC) proliferation, hydrogen sulfide, nuclear factor kappa-B (NF-κB), oxidative stress, and epigenetics/epigenomics. Each of the aforementioned keywords was co-joined with plant or herb in question, and where possible with its constituent molecule(s). This part deals in particular with plants that are used, albeit less frequently, for the treatment and management of hypertension. We then discuss the interplay between herbs/prescription drugs and herbs/epigenetics in the context of this disease. The review then concludes with a recommendation for more rigorous, well-developed clinical trials to concretely determine the beneficial impact of herbs and plants on hypertension and a disease-free living.

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Section: Herbs and Spices Less Commonly Used For Treatment Of Hypertementioning

confidence: 99%

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

2016

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“…Raja et al studied the effect of M. maderaspatana leaf-tea consumption on blood pressure, lipid profile, anthropometry, fibrinogen, bilirubin, and albumin levels in patients with hypertension. They concluded that there was a gradual decrease in BP and also beneficial effects in others [29]. Subramani et al, synthesized silver nanoparticles (AgNP) using M. maderaspatana and evaluated their antibacterial activity.…”

Section: Other Propertiesmentioning

confidence: 99%

Phytopharmacological Properties of Melothria Maderaspatana: A Review

Paramasivam

Sinsinwar

Muthuraman

2017

Asian J Pharm Clin Res

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A medicinal plant plays a vital role in traditional systems. It is necessary to study the pharmacology activity of individual plants for treating diseases. Melothria maderaspatana Linn. belongs to the family of Cucurbitaceae, mostly present in South India, and it shows biological activities such as antibacterial, antioxidant, larvicidal, antiulcerogenic, antidiabetic, hypolipidemic, antihypertensive, immunomodulatory, and antihepatotoxic for treating various diseases which are discussed in this review paper.

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“…This plant extract has also been shown to have hepatoprotective, [5] immunomodulatory [6] activities in rat models. Our previous studies showed that M. maderaspatana leaf extract has antihypertensive, antioxidant and antihyperlipidemic properties in hypertensive patients [7,8]. Some of these ethnomedical and reported biological activities may be due to the antioxidant nature of M. maaderaspatana.…”

Section: Introductionmentioning

confidence: 97%

Evaluation of antioxidant activity of Melothria maderaspatana in vitro

Raja

Pugalendi

2010

Open Life Sciences

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Abstract:In this study, an aqueous extract of leaves from Melothria maderaspatana was tested for in vitro antioxidant activity. Free radical scavenging assays, such as hydroxyl radical, hydrogen peroxide, superoxide anion radical and 2,2-diphenyl-1-picryl hydrazyl (DPPH), 2,2'-azinobis-(3-ethyl-enzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, and reducing power assay, were studied. The extract effectively scavenged hydroxyl radical, hydrogen peroxide and superoxide anion radicals. It also scavenged DPPH and ABTS radicals. Furthermore, it was found to have reducing power. All concentrations of leaf extract exhibited free radical scavenging and antioxidant power, and the preventive effects were in a dose-dependent manner. The antioxidant activities of the above were compared to standard antioxidants such as butylated hydroxytoluene (BHT), ascorbic acid, and α-tocopherol. The results obtained in the present study indicate that the M. maderaspatana extract could be considered a potential source of natural antioxidant.© Versita Sp. z o.o.

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Effect ofMelothria maderaspatanaLeaf-Tea Consumption on Blood Pressure, Lipid Profile, Anthropometry, Fibrinogen, Bilirubin, and Albumin Levels in Patients with Hypertension

Abstract: Thus, M. maderaspatana leaf-tea consumption gradually decreased BP and showed beneficial effects on blood lipid profile, fibrinogen, bilirubin, and body mass index in patients with hypertension.

Cited by 12 publications

References 36 publications

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

Phytopharmacological Properties of Melothria Maderaspatana: A Review

Evaluation of antioxidant activity of Melothria maderaspatana in vitro

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