Effect of<i>Momordica dioica</i>Roxb on gentamicin model of acute renal failure

Jain, Anju; Singhai, A. K.

doi:10.1080/14786410802267569

Cited by 30 publications

(25 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By severely altering mitochondrial function in the liver, drugs can induce hepatic necrosis, causing cystolytic hepatitis, and can progress into liver failure [13].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Aboubakr

Abdelazem

2015

IJBAS

View full text Add to dashboard Cite

The study was designed to evaluate the hepatoprotective activity of aqueous extract of cardamom in acute experimental liver injury induced by gentamicin. Twenty four male albino rats were randomly divided into four groups (six rats in each). Animals of the first group served as control and orally (p.o.) received (1 ml/kg saline). The second experimental group was given gentamicin (80 mg/kg i.p.) for 7 days. Third and fourth groups were given aqueous extract of cardamom (100 and 200 mg/kg p.o.) + gentamicin for 7 days, respectively. The degree of hepatoprotection was measured using serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. In the acute liver damage induced by gentamicin, cardamom aqueous extracts (100 and 200 mg/kg, p.o.) significantly reduced the elevated serum levels of AST, ALT, bilirubin, cholesterol, triglycerides and low density lipoprotein cholesterol (LDL-chol) in gentamicin induced hepatotoxicity. Also cardamom aqueous extracts (100 & 200 mg/kg, p.o.) significantly increased the lowered serum levels of albumin and high density lipoprotein cholesterol (HDL-chol) in gentamicin induced hepatotoxicity rats. Histopathological examination of the liver tissues supported the hepatoprotection. Our findings concluded that cardamom aqueous extracts possessed hepatoprotective activity against gentamicin induced hepatotoxicity in rats.

show abstract

“…By severely altering mitochondrial function in the liver, drugs can induce hepatic necrosis, causing cystolytic hepatitis, and can progress into liver failure [13].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Aboubakr

Abdelazem

2015

IJBAS

View full text Add to dashboard Cite

show abstract

“…This plant also possesses hypoglycaemic, gastro-protective and ulcer healing activities. The fruit is reported for its hepatoprotective activity (Jain & Singhai, 2008).…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective activity ofMomordica dioicaRoxb. in cisplatin-induced nephrotoxicity

Jain

Singhai

2010

Natural Product Research

Self Cite

View full text Add to dashboard Cite

In this study, the ethanol extract of Momordica dioica fruit extract (200 mg kg(-1)) was studied for nephroprotective and curative activities. Chloroform, ethyl acetate, ethanol and aqueous extracts were prepared. In vitro antioxidant activity was made the basis for the selection of the ethanol extract for further studies. In DPPH free radical scavenging activity, the ethanolic extract has shown maximum inhibition (84.2%), followed by aqueous (74.8%), ethyl acetate (69.4%) and chloroform (59.7%) extract. On the other hand, in total antioxidant activity, the ethanol extract has shown 80.1% inhibition, followed by aqueous (71.9%), ethyl acetate (67.2%) and chloroform (53.2%) extracts. A single dose (5 mg kg(-1), i.p.) of cisplatin was administrated to induce nephrotoxicity. Blood urea and serum creatinine were analysed as biochemical markers of nephrotoxicity. Reduced glutathione (GSH) and the product of lipid peroxidation (MDA) were also measured in kidney tissues. A single dose of cisplatin resulted in significant reduction in body weight and increased the urea and creatinine levels. Extract administration has shown significant recovery in the levels of these biochemicals in curative (p < 0.001) and protective groups, whereas a single dose of cisplatin caused significant reduction in GSH and an increase in malondialdehyde production. Recovery was observed in treated groups. This study suggested that the nephroprotective and curative activities of M. dioica fruit extract are due to its antioxidant activity. It is further concluded that this antioxidant activity may be attributed to the phenolics, flavonoids and amino acids present in the extract.

show abstract

“…Hepatotoxicty or liver damage is the irregular functioning of the liver; with mitochondrial dysfunction reported as one of the major mechanism of drugs induce hepatotoxicity. By severely altering mitochondrial function in the liver, drugs can induce hepatic necrosis, causing cystolytic hepatitis, and can progress into liver failure [2] . When the liver is damaged, it may not be able to perform these functions optimally causing the accumulation of toxins in the body faster than the liver can process.…”

Section: Introductionmentioning

confidence: 99%

Modulatory effects of dietary inclusion of garlic (Allium sativum) on gentamycin–induced hepatotoxicity and oxidative stress in rats

Ademiluyi

Oboh

Owoloye

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

Effect ofMomordica dioicaRoxb on gentamicin model of acute renal failure

Cited by 30 publications

References 15 publications

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Nephroprotective activity ofMomordica dioicaRoxb. in cisplatin-induced nephrotoxicity

Modulatory effects of dietary inclusion of garlic (Allium sativum) on gentamycin–induced hepatotoxicity and oxidative stress in rats

Contact Info

Product

Resources

About