Effect of <i>Moringa oleifera</i> Leaf Capsules on Glycemic Control in Therapy‐Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study

Taweerutchana, Rutchaporn; Lumlerdkij, Natchagorn; Vannasaeng, Sathit; Akarasereenont, Pravit; Sriwijitkamol, Apiradee

doi:10.1155/2017/6581390

Cited by 47 publications

(35 citation statements)

References 19 publications

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“…However, the author suggested that this might be due to the short duration of the study, and therefore, long‐term studies are required to determine the effect of moringa leaves on glycemic control. Interestingly, moringa leaves showed no adverse effects in the subjects; for example, no differences were found in creatinine, blood urea nitrogen, alanine aminotransferase, and aspartate aminotransferase between start and end of the experiment in both groups (Taweerutchana, Lumlerdkij, Vannasaeng, Akarasereenont, & Sriwijitkamol, ).…”

Section: Human Studiesmentioning

confidence: 94%

Moringa oleiferaand glycemic control: A review of current evidence and possible mechanisms

Ahmad

Khan

Blundell

2019

Phytotherapy Research

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Maintaining glycemic control in diabetes and prediabetes is necessary to prevent many health complications and mortality. Although different hypoglycemic drugs are used for this purpose, there is still a growing interest in the use of medicinal plants due to their low price, easy availability, and fewer or no side effects. Moringa (Moringa oleifera Lam.) is a medicinal plant that has been traditionally used in the management of diabetes. This review aims to present the existing literature published until February 2019 on the role of moringa leaves in glycemia and their physiological mechanisms. In the conducted studies, moringa leaves have shown to reduce glycemia, without causing any adverse effects. The proposed mechanisms for reducing glycemia include inhibition of α‐amylase and α‐glucosidase activities, increased glucose uptake in the muscles and liver, inhibition of glucose uptake from the intestine, decreased gluconeogenesis in the liver, and increased insulin secretion and sensitivity. However, these studies are limited in numbers and mostly conducted in animals, in vitro and in vivo. Therefore, long‐term human studies are required to determine the hypoglycemic effect of moringa leaves, their physiological mechanisms, active ingredients, and safety. Overall, this review provides evidence that moringa leaves have the possibility to be used as a glycemic control agent in diabetes and prediabetes.

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Section: Human Studiesmentioning

confidence: 94%

Moringa oleiferaand glycemic control: A review of current evidence and possible mechanisms

Ahmad

Khan

Blundell

2019

Phytotherapy Research

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“…Participants were asked to fast for at least 8 h before MO ingestion and to maintain their typical diet, physical activity, and general lifestyle throughout the study. Furthermore, a randomized placebo controlled clinical study that compared the effect of MO leaf capsules and placebo in therapy-naïve type 2 DM patients, found no significant differences in glycaemia or HbA 1C levels [80]. The patients received 4 g of MO leaf powder capsules twice a day, before breakfast and before dinner, over a period of four weeks.…”

Section: Clinical Evidence Of Mo Effects On Glucose and Insulinmentioning

confidence: 98%

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

2019

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Diabetes and related neurological complications are serious worldwide public health problems. The increasing number of affected individuals make it necessary to implement novel nutritional and therapeutic interventions. The tree Moringa oleifera (MO) has been used as a food source and for traditional medicine purposes due to possible antihyperglycemic, antioxidant, anti-inflammatory, and lipid regulating properties. These properties may be explained by the presence of numerous phytochemicals in the leaves, fruits, roots and, oil of the tree. The evidence for acute antihyperglycemic effects of MO extract on diabetic animal models seems to be robust, but more chronic and long-term studies are needed. In contrast, the hypoglycemic effects of MO on humans are not as clear. The scarce number of human studies, together with a diverse range of methodologies and MO doses, may explain this. In addition, evidence regarding changes in insulin levels due to MO intervention is ambiguous, both in animal and human studies. Therefore, more structured studies are needed to clarify if MO has an effect on insulin levels or activity.

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“…A randomized-placebo controlled study was performed by Taweerutchana et al [70], including 32 therapy-naïve DM patients whose glucose control was evaluated while undergoing a short-term therapy (28 days) with eight daily capsules of either MO (4 g/d) or placebo. The volunteers performed 9-point glucose measurements weekly with a glucometer, which included premeal and postmeal measurements.…”

Section: Scientific Evidences Of M Oleifera Effect On Glucose Contromentioning

confidence: 99%

Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies

et al. 2020

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Moringa oleifera (MO) is a multipurpose plant consumed as food and known for its medicinal uses, among others. Leaves, seeds and pods are the main parts used as food or food supplements. Nutritionally rich and with a high polyphenol content in the form of phenolic acids, flavonoids and glucosinolates, MO has been shown to exert numerous in vitro activities and in vivo effects, including hypoglycemic activity. A systematic search was carried out in the PubMed database and reference lists on the effects of MO on glucose metabolism. Thirty-three animal studies and eight human studies were included. Water and organic solvent extracts of leaves and, secondly, seeds, have been extensively assayed in animal models, showing the hypoglycemic effect, both under acute conditions and in long-term administrations and also prevention of other metabolic changes and complications associated to the hyperglycemic status. In humans, clinical trials are scarce, with variable designs and testing mainly dry leaf powder alone or mixed with other foods or MO aqueous preparations. Although the reported results are encouraging, especially those from postprandial studies, more human studies are certainly needed with more stringent inclusion criteria and a sufficient number of diabetic or prediabetic subjects. Moreover, trying to quantify the bioactive substances administered with the experimental material tested would facilitate comparison between studies.

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Effect of Moringa oleifera Leaf Capsules on Glycemic Control in Therapy‐Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study

Cited by 47 publications

References 19 publications

Moringa oleiferaand glycemic control: A review of current evidence and possible mechanisms

Moringa oleiferaand glycemic control: A review of current evidence and possible mechanisms

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

Potential of Moringa oleifera to Improve Glucose Control for the Prevention of Diabetes and Related Metabolic Alterations: A Systematic Review of Animal and Human Studies

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