Effect of <i>N</i>‐acetylcysteine on motivation, seeking and relapse to ethanol self‐administration

Lebourgeois, Samuel; González-Marín, María Carmen; Jeanblanc, Jérôme; Naassila, Mickaël; Vilpoux, Catherine

doi:10.1111/adb.12521

Cited by 57 publications

(52 citation statements)

References 59 publications

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“…In this regard, we recently used this BD model to show that N ‐acetylcysteine, which has been used off‐label to reduce craving in cocaine addiction, could also effectively reduce BD behavior (Lebourgeois et al . ). Thus indicating that our BD model has a good predictive validity.…”

Section: Discussionmentioning

confidence: 97%

Face validity of a pre‐clinical model of operant binge drinking: just a question of speed

et al. 2018

Self Cite

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Binge drinking (BD) is often defined as a large amount of alcohol consumed in a 'short' period of time or 'per occasion'. In clinical research, few researchers have included the notion of 'speed of drinking' in the definition of BD. Here, we aimed to describe a novel pre-clinical model based on voluntary operant BD, which included both the quantity of alcohol and the rapidity of consumption. In adult Long-Evans male rats, we induced BD by regularly decreasing the duration of ethanol self-administration from 1-hour to 15-minute sessions. We compared the behavioral consequences of BD with the behaviors of rats subjected to moderate drinking or heavy drinking (HD). We found that, despite high ethanol consumption levels (1.2 g/kg/15 minutes), the total amounts consumed were insufficient to differentiate HD from BD. However, consumption speed could distinguish between these groups. The motivation to consume was higher in BD than in HD rats. After BD, we observed alterations in locomotor coordination in rats that consumed greater than 0.8 g/kg, which was rarely observed in HD rats. Finally, chronic BD led to worse performance in a decision-making task, and as expected, we observed a lower stimulated dopaminergic release within nucleus accumbens slices in poor decision makers. Our BD model exhibited good face validity and can now provide animals voluntarily consuming very rapidly enough alcohol to achieve intoxication levels and thus allowing the study of the complex interaction between individual and environmental factors underlying BD behavior.

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Section: Discussionmentioning

confidence: 97%

Face validity of a pre‐clinical model of operant binge drinking: just a question of speed

et al. 2018

Self Cite

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“…In well‐conducted studies, Lebourgeois and colleagues () showed that an i.p. of NAC (100 mg/kg) administered 60 minutes before operant‐cued relapse testing markedly inhibited EtOH relapse.…”

Section: Discussionmentioning

confidence: 99%

Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar‐Derived UChB Rats: Inhibition by N‐Acetylcysteine

Quintanilla

Morales

Ezquer

et al. 2018

Alcoholism Clin & Exp Res

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“…) and on ethanol seeking (Lebourgeois et al . ) could conceivably be explained by its anti‐inflammatory effects (Schneider et al . ).…”

Section: Discussionmentioning

confidence: 99%

Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse‐like drinking in high‐alcohol drinker rats

Ezquer

Quintanilla²,

Morales³

et al. 2017

Addiction Biology

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Neuroinflammation has been reported to follow chronic ethanol intake and may perpetuate alcohol consumption. Present studies determined the effect of human mesenchymal stem cells (hMSCs), known for their anti-inflammatory action, on chronic ethanol intake and relapse-like ethanol intake in a post-deprivation condition. Rats were allowed 12-17 weeks of chronic voluntary ethanol (10% and 20% v/v) intake, after which a single dose of activated hMSCs (5 × 10 ) was injected into a brain lateral ventricle. Control animals were administered vehicle. After assessing the effect of hMSCs on chronic ethanol intake for 1 week, animals were deprived of ethanol for 2 weeks and thereafter an ethanol re-access of 60 min was allowed to determine relapse-like intake. A single administration of activated hMSCs inhibited chronic alcohol consumption by 70% (P < 0.001), an effect seen within the first 24 hours of hMSCs administration, and reduced relapse-like drinking by 80% (P < 0.001). In the relapse-like condition, control animals attain blood ethanol ('binge-like') levels >80 mg/dl. The single hMSC administration reduced relapse-like blood ethanol levels to 20 mg/dl. Chronic ethanol intake increased by 250% (P < 0.001) the levels of reactive oxygen species in hippocampus, which were markedly reduced by hMSC administration. Astrocyte glial acidic fibrillary protein immunoreactivity, a hallmark of neuroinflammation, was increased by 60-80% (P < 0.001) by chronic ethanol intake, an effect that was fully abolished by the administration of hMSCs. This study supports the neuroinflammation-chronic ethanol intake hypothesis and suggest that mesenchymal stem cell administration may be considered in the treatment of alcohol use disorders.

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Effect of N‐acetylcysteine on motivation, seeking and relapse to ethanol self‐administration

Cited by 57 publications

References 59 publications

Face validity of a pre‐clinical model of operant binge drinking: just a question of speed

Face validity of a pre‐clinical model of operant binge drinking: just a question of speed

Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar‐Derived UChB Rats: Inhibition by N‐Acetylcysteine

Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse‐like drinking in high‐alcohol drinker rats

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