Effect of <i>Persea americana</i> (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity

Padmanabhan, M.; Geetha, A

doi:10.1515/jcim-2013-0053

Cited by 26 publications

(19 citation statements)

References 48 publications

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“…Organ indices have always been regarded as important in the evaluation of immune function in animals. Research has shown that liver, kidney, and spleen indices will be lower than average when animals have an autoimmune disease, thereby indirectly reflecting the health condition of the animal . There was no significant difference ( P > 0.05) in the kidney and spleen indices amongst all treatment groups, indicating that ME LIP‐1 and NME LIP‐1 had no negative side effects on rats (Table ).…”

Section: Resultsmentioning

confidence: 96%

“…Research has shown that liver, kidney, and spleen indices will be lower than average when animals have an autoimmune disease, thereby indirectly reflecting the health condition of the animal. 17 There was no significant difference (P > 0.05) in the kidney and spleen indices amongst all treatment groups, indicating that ME LIP-1 and NME LIP-1 had no negative side effects on rats ( Table 6). In contrast, the liver index was significantly higher in the model (high-fat) group than in the other three groups (7.38 ± 0.010 versus 6.45 ± 0.007/5.77 ± 0.006/5.72 ± 0.008, P < 0.05), which may be due to the high fat content of the feed accumulating in the liver and increasing the liver index (Table 6).…”

Section: Effect Of Me Lip-1 Treatment On Organ Indicesmentioning

confidence: 88%

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Antihyperlipidaemic effect of microencapsulated Lactobacillus plantarum LIP‐1 on hyperlipidaemic rats

et al. 2020

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BACKGROUND Previous studies have shown that Lactobacillus plantarum LIP‐1 (hereafter LIP‐1) has an obvious hypolipidemic effect, and microencapsulated probiotics can ensure the strains live through the gastrointestinal tract. Although there has been much research on both preparation and assessment methods for probiotics microcapsules, most assessments were made in vitro and few were validated in vivo. In this study, the protective effect of microencapsulation and the possible hypolipidemic mechanisms of probiotic LIP‐1 were evaluated in rats. Treatments included rats fed on a normal diet, a high‐fat diet, and a high‐fat diet with an intragastric supplement of either non‐microencapsulated LIP‐1 cells (NME LIP‐1) or microencapsulated LIP‐1 (ME LIP‐1). Lipid metabolism indicators were measured during the experiment and following euthanasia. RESULTS Microencapsulation increased survival and colonization of LIP‐1 in the colon. ME LIP‐1 was superior to NME LIP‐1 in reducing cholesterol. The mechanisms behind the hypolipidemic effect exerted by LIP‐1 are possibly due to promoting the excretion of cholesterol, improving antioxygenic potentials, enhancing recovery from the injury in the liver, cardiovascular intima and intestinal mucosa, promoting the generation of short‐chain fatty acids, and improving lipid metabolism. CONCLUSIONS This study confirms that microencapsulation provides effective protection of LIP‐1 in the digestive system and the role of LIP‐1 in the prevention and cure of hyperlipidaemia, providing theoretical support for probiotics to enter clinical applications. © 2019 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 96%

Section: Effect Of Me Lip-1 Treatment On Organ Indicesmentioning

confidence: 88%

Antihyperlipidaemic effect of microencapsulated Lactobacillus plantarum LIP‐1 on hyperlipidaemic rats

et al. 2020

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“…AT regulates energy homeostasis, carbohydrate as well as lipid metabolism and also IS, while AT dysfunction promotes weight gain, visceral adiposity, and IR. [25,34] Since adiponectin enhances FFA oxidation; therefore, hypoadiponectinemia would also encourage weight gain and visceral adiposity as observed in HFrC. [12] Administration of PGZ had promoted, and cinnamon extracts had reversed the weight gain in HFr fed rats.…”

Section: Discussionmentioning

confidence: 99%

“…ADI is a ratio of visceral fat weight to body weight and expressed as adiposity percentage (%). [25] Sum of total fat pad mass -×100 Body weight ADI…”

Section: Assessment Of Weight Gain Adiposity and Adiposity Index (Adi)mentioning

confidence: 99%

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M.N¹

2019

IJGP

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Introduction: Evidence(s) established that high fructose (HFr) diet may be responsible for the development of insulin resistance (IR). The aim is to appraise the ameliorative effects of Cinnamomum zeylanicum bark extracts on adiposity, insulin sensitivity (IS) and cardiometabolic markers in HFr diet-induced IR. Materials and Methods: A total of 30 Wistar male albino rats (240-300 g) were divided into five groups (n = 6) and had free access to both diet and water. Groups I and II served as normal control and HFr control (HFrC), received gum acacia (2%) and fructose (60% w/v) diet. Groups III-V were orally administered pioglitazone (PGZ 50 mg/kg/b.wt), aqueous (Cinnamon bark aqueous extract [CBAE] 1 g/kg/b.wt), and ethanolic (Cinnamon bark ethanolic extract [CBEE] 1 g/kg/b.wt) extracts of cinnamon bark, respectively, from day 28 onwards till end of the study. All the groups, except normal control received HFr diet for 42 days. At the end weight gain, adiposity, adiponectin, and cardiometabolic markers (C-reactive protein and uric acid), and cardiovascular (CV) risks, IR and IS indices were evaluated. Results: HFr feeding significantly increased weight gain, adiposity and decreased adiponectin levels along with increased cardiometabolic markers as compared to normal control. HFrC significantly increased the CV and decreased IS indices as compared to normal control. PGZ, CBAE, and CBEE groups significantly reduced adiposity, and both cinnamon groups had decreased the weight gain as compared to HFrC. PGZ and CBAE significantly increased adiponectin levels, whereas cinnamon groups and PGZ had decreased cardiometabolic markers as compared to HFrC. Similarly, PGZ and cinnamon extracts had improved IS as compared to HFrC. Conclusion: The study concluded that cinnamon extracts had exhibited insulin-sensitizing effects in IR and associated metabolic risk factors by modulating adiponectin in HFr fed rats. Therefore, the study proposes to use cinnamon as a functional food supplement in the management of diabetes and obesity.

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“…So, identifying this potent herbs or active constituent is a good choice for study in treatment of metabolic syndrome (Sahebkar, ; Hosseinzadeh and Nassiri‐Asl, ; Razavi and Hosseinzadeh, ; Hosseini and Hosseinzadeh, ). Several plants and active constituents such as, Nigella sativa (Razavi and Hosseinzadeh, ), Rosmarinus officinalis (Hassani et al, ), rutin (a flavonoid) (Hosseinzadeh and Nassiri‐Asl, ), Allium sativum (Garlic) (Hosseini and Hosseinzadeh, ), Vitis vinifera (Grape) (Akaberi and Hosseinzadeh, ), Persea americana (avocado) (Padmanabhan and Arumugam, ), Rubus occidentalis (An et al, ), Glycyrrhizin (triterpenoid saponin of Glycyrrhiza glabra root) (Sil and Chakraborti, ), Linum usitatissimum (Flaxseed Supplementation) (Yari et al, ), Pinus pinaster (Pycnogenol® or extract from the outer bark of Pinus pinaster ) (Gulati, ), Crocus sativus (Razavi and Hosseinzadeh, ) and cinnamon obtained from genus Cinnamomum (Mollazadeh and Hosseinzadeh, ) have been used to treat metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

Review ofGarcinia mangostanaand its Xanthones in Metabolic Syndrome and Related Complications

2017

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Metabolic syndrome is coexistence of abdominal obesity, hyperglycemia, hyperlipidemia and hypertension that causes cardiovascular diseases, diabetes and their complications, low quality and short lifespan. Garcinia mangostana and its xanthones such as α-mangostin have been shown desirable effects such as anti-obesity, anti-hyperglycemic, anti-dyslipidemia, anti-diabetic and antiinflammatory effects in experimental studies. Various databases such as PubMed, Scopus and Web of Science with keywords of 'Garcinia mangostana', 'mangosteen', 'α-mangostin', 'metabolic syndrome', 'hypoglycemic', 'antihyperglicemic', 'antidiabetic', 'hypotensive', 'antihypertensive', 'atherosclerosis', 'arteriosclerosis' and 'hyperlipidemia' have been investigated in this search without publication time limitation. This study reviewed all pharmacological effects and molecular pathways of G. mangostana and its xanthones in the management of metabolic syndrome and its complications in in-vitro and in-vivo studies. Based on these studies, mangosteen and its xanthones have good potential to design human studies for controlling and modification of metabolic syndrome and its related disorders such as obesity, disrupted lipid profile, diabetes and its complications. Copyright © 2017 John Wiley & Sons, Ltd.

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Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity

Abstract: The results indicate that HAEPA exhibits hypolipidemic activity probably by increasing the mRNA expression of adiponectin and PPAR-γ, which reduce the risk of hyperlipidemia and obesity.

Cited by 26 publications

References 48 publications

Antihyperlipidaemic effect of microencapsulated Lactobacillus plantarum LIP‐1 on hyperlipidaemic rats

Antihyperlipidaemic effect of microencapsulated Lactobacillus plantarum LIP‐1 on hyperlipidaemic rats

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Review ofGarcinia mangostanaand its Xanthones in Metabolic Syndrome and Related Complications

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