Effect of <i><scp>FTO</scp></i> rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C‐reactive protein levels in multi‐ethnic Malaysian adults

Mitra, Soma; Tan, Pui Yee; Amini, Farahnaz

doi:10.1111/jhn.12593

Cited by 12 publications

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“…Detailed information on the study design and methods can be found in our earlier publication [16]. Therefore, with respect to assessment of anthropometric parameters, dietary nutrients analysis, and physical activity level assessment, we refer the readers to our earlier publication [16].…”

Section: Methodsmentioning

confidence: 99%

“…Low-density lipoprotein (LDL) cholesterol was calculated using the Friedewald formula: LDL cholesterol = total cholesterol − ((triglyceride/5) + HDL cholesterol) [18]. This information has been reported in our earlier publication [16]. This study investigates ADRB2 rs1042713 gene polymorphism in the same population with the aim to evaluate (i) the effect of ADRB2 rs1042713 on obesity and obesity-related anthropometric and blood biochemical parameters and (ii) the influence of diet on the association between ADRB2 rs1042713 and obesity phenotypes.…”

Section: Methodsmentioning

confidence: 99%

“…This study is nested in a broader study investigating the association of single nucleotide polymorphisms in genes that have widely been reported to influence obesity and obesity-related metabolic disorders in human individuals. In an earlier publication, we have reported that FTO rs9930506 may interact with dietary protein and Vitamin E intake and modulate hsCRP levels in our Malaysian participants [16]. The aim of the current study was to evaluate (i) the effect of ADRB2 rs1042713 on obesity and obesity-related anthropometric and blood biochemical parameters and (ii) the influence of diet on the association between ADRB2 rs1042713 and obesity phenotypes, in Malaysian adults.…”

Section: Introductionmentioning

confidence: 94%

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Association ofADRB2rs1042713 with Obesity and Obesity-Related Phenotypes and Its Interaction with Dietary Fat in Modulating Glycaemic Indices in Malaysian Adults

Mitra

Tan

Amini

2019

Journal of Nutrition and Metabolism

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Gene-diet interaction studies have reported that individual variations in phenotypic traits may be due to variations in individual diet. Our study aimed to evaluate (i) the association of ADRB2 rs1042713 with obesity and obesity-related metabolic parameters and (ii) the effect of dietary nutrients on these associations in Malaysian adults. ADRB2 genotyping, dietary, physical activity, anthropometric, and biochemical data were collected from 79 obese and 99 nonobese individuals. Logistic regression revealed no association between ADRB2 rs1042713 and obesity (p=0.725). However, the carriers of G allele (AG + GG genotypes) of rs1042713 were associated with increased odds of insulin resistance, 2.83 (CI = 1.04–7.70, adjusted p=0.042), in the dominant model, even after adjusting for potential confounders. Obese individuals carrying the G allele were associated with higher total cholesterol (p=0.011), LDL cholesterol levels (p=0.008), and total cholesterol/HDL cholesterol ratio (p=0.048), compared to the noncarriers (AA), even after adjusting for potential confounders. Irrespective of obesity, the carriers of GG genotype had significantly lower fasting glucose levels with low saturated fatty acid intake (<7.3% of TE/day) (4.92 ± 0.1 mmol/L vs 5.80 ± 0.3 mmol/L, p=0.011) and high intake of polyunsaturated fatty acid:saturated fatty acid ratio (≥0.8/day) (4.83 ± 0.1 mmol/L vs 5.93 ± 0.4 mmol/L, p=0.006). Moreover, the carriers of GG genotype with high polyunsaturated fatty acid intake (≥6% of TE/day) had significantly lower HOMA-IR (1.5 ± 0.3 vs 3.0 ± 0.7, p=0.026) and fasting insulin levels (6.8 ± 1.6 µU/mL vs 11.4 ± 2.1 µU/mL, p=0.036). These effects were not found in the noncarriers (AA). In conclusion, G allele carriers of ADRB2 rs1042713 were associated with increased odds of insulin resistance. Obese individuals carrying G allele were compromised with higher blood lipid levels. Although it is premature to report gene-diet interaction on the regulation of glucose and insulin levels in Malaysians, we suggest that higher quantity of PUFA-rich food sources in regular diet may benefit overweight and obese Malaysian adults metabolically. Large-scale studies are required to replicate and confirm the current findings in the Malaysian population.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Association ofADRB2rs1042713 with Obesity and Obesity-Related Phenotypes and Its Interaction with Dietary Fat in Modulating Glycaemic Indices in Malaysian Adults

Mitra

Tan

Amini

2019

Journal of Nutrition and Metabolism

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“…Use a logical sequence when listing the methods that you used. Try to do this following a chronological sequence, as shown in recently published examples .…”

Section: Writing the Methodsmentioning

confidence: 99%

Editorial: How to Write

Langley‐Evans

2019

J Human Nutrition Diet

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“…This study is nested in a broader study investigating the association of SNP in fat mass and obesity-associated ( FTO ) gene with obesity traits and their interaction with dietary factors in Malaysian adults of three different ethnic groups. We found significant interaction between FTO rs9930506 with dietary protein and vitamin E on high-sensitivity C-reactive protein (hsCRP) levels ( 28 ) . Strong association of FTO gene and obesity-related traits have been consistently observed in studies involving various populations worldwide ( 29 – 31 ) .…”

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Effect of an individualised high-protein, energy-restricted diet on anthropometric and cardio-metabolic parameters in overweight and obese Malaysian adults: a 6-month randomised controlled study

Mitra

Tan

2019

Br J Nutr

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The aim of this study was to investigate the effectiveness of the Hipcref (high-protein, energy-restricted, high-vitamin E and high-fibre) diet in Malaysian adults on body composition and metabolic parameters after an intervention period of 6 months. Overweight/obese Malaysian adults (n 128; BMI≥23 kg/m2) were randomised to the Hipcref (n 65) or control diet (n 63). The intervention group received Hipcref diet charts based on their personal preferences. The control group followed a generalised dietary advice based on Malaysian Dietary Guidelines, 2010. All participants were responsible for preparing their own meals. There was a significant treatment group×time effect on anthropometric parameters (P<0·05) on an intention-to-treat basis. Pairwise comparisons revealed that Hipcref diet participants had significant reduction in weight, BMI, waist circumference, fat mass and percentage body fat at months 3 and 6 compared with baseline (P<0·001). The control group had significant increase in weight and BMI at months 3 and 6 compared with baseline (P<0·05). The Hipcref diet group had higher reduction in fasting insulin, insulin resistance and C-reactive protein levels compared with the control group at month 6 (P<0·05). Post-intervention, compared with the control group, the Hipcref diet group was found to consume significantly higher percentage energy from protein, and PUFA, higher energy-adjusted vitamin E (mg) and fibre (g), and lower total energy, lower percentage energy from fat and carbohydrate (P<0·05). The success of the Hipcref diet on overweight/obese Malaysian adults may be due to the combined effect of the nutrient composition of the Hipcref diet.

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Effect of FTO rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C‐reactive protein levels in multi‐ethnic Malaysian adults

Cited by 12 publications

References 54 publications

Association ofADRB2rs1042713 with Obesity and Obesity-Related Phenotypes and Its Interaction with Dietary Fat in Modulating Glycaemic Indices in Malaysian Adults

Association ofADRB2rs1042713 with Obesity and Obesity-Related Phenotypes and Its Interaction with Dietary Fat in Modulating Glycaemic Indices in Malaysian Adults

Editorial: How to Write

Effect of an individualised high-protein, energy-restricted diet on anthropometric and cardio-metabolic parameters in overweight and obese Malaysian adults: a 6-month randomised controlled study

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