Effect of <i><scp>H</scp>elicobacter pylori</i> infection on esophagogastric variceal bleeding in patients with liver cirrhosis and portal hypertension

Sakamoto, Yoshihiro; Oho, Kazuhiko; Toyonaga, Atsushi; Kumamoto, Masafumi; Haruta, Tsuyoshi; Inoue, Hiroto; Emori, Keigo; Takahashi, Osamu; Sata, Michio

doi:10.1111/jgh.12221

Cited by 15 publications

(13 citation statements)

References 49 publications

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“…This means that H. pylori infection might be implicated as a risk factor for bleeding from gastric varices. In contrary to our results, Sakamoto et al [11] reported higher rates of H. pylori infection in patients without variceal bleeding in comparison to those with bleeding (55.4% and 31.6%, respectively) ( P = 0.001), indicating that H. pylori might have a protective effect against variceal bleeding.…”

Section: Discussioncontrasting

confidence: 99%

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Impact of Helicobacter pylori Infection on Gastric Variceal Bleeding among Patients with Liver Cirrhosis

Elsebaey

Tawfik

Elshweikh

et al. 2019

Gastroenterology Research and Practice

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Background and Aims. Currently, it is well known that Helicobacter pylori- (H. pylori-) related peptic ulcer is one of the main causes of nonvariceal bleeding in cirrhotic patients. However, there is a lack of data to identify the exact effect ofH. pyloriinfection on variceal bleeding. This study was conducted to identify the impact ofH. pyloriinfection on gastric variceal bleeding in cirrhotic patients.Patients and Methods. 76 cirrhotic patients with gastric varices were included in this prospective study and divided into 2 groups: nonbleeding gastric varices (32 patients) and bleeding gastric varices (44 patients). The fasting serum gastrin level was measured. Mucosal biopsies from the gastric body and antrum were examined to determine the patterns of gastritis and the presence ofH. pylori.Results. The frequency ofH. pyloriinfection in the studied patients was 59.2%. There were significant differences between both groups regarding liver decompensation (P=0.001), red color sign over gastric varices (P=0.0011), prevalence ofH. pyloriinfection (P=0.0049), histological patterns of gastritis (P=0.0069), and serum gastrin level (P=0.0200). By multivariate analysis, Child C cirrhosis, red color sign over gastric varices, andH. pylori-induced follicular gastritis were independent risk factors for bleeding from gastric varices.Conclusion.H. pylori-induced follicular gastritis is considered as an additional risk factor for bleeding from gastric varices.

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Section: Discussioncontrasting

confidence: 99%

“…There are limited studies that discussed the relation between H. pylori infection and variceal bleeding [11]. To address this issue, we conducted this study to assess the effect of H. pylori infection on bleeding from gastric varices in cirrhotic patients.…”

Section: Introductionmentioning

confidence: 99%

Impact of Helicobacter pylori Infection on Gastric Variceal Bleeding among Patients with Liver Cirrhosis

Elsebaey

Tawfik

Elshweikh

et al. 2019

Gastroenterology Research and Practice

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“…There are many studies showing association or protective role of H. pylori infection in different disease groups, for example, reducing Barrett's esophagitis [37], decreasing risk of esophageal cancer [38], decreasing risk of gastric cardiac cancer [39], or decreasing the bleeding risk of esophageal varices in cirrhotic patients [40]. According to our findings, H. pylori infection may be candidate agent which plays a protective role in gastroenteritis in children.…”

Section: Discussionsupporting

confidence: 63%

The Relation betweenHelicobacter pyloriInfection and Acute Bacterial Diarrhea in Children

Monajemzadeh

Abbasi

Tanzifi

et al. 2014

International Journal of Pediatrics

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Background. H. pylori infection leads to chronic gastritis in both children and adults. But recently, there are arising theories of its protective effect in diarrheal diseases. Aim. To explore the prevalence of H. pylori infection in children with bacterial diarrhea and compare it with healthy controls. Patients and Methods. Two matched groups consisted of 122 consecutive children, aged 24–72 months old, with acute bacterial diarrhea, who had Shigellosis (N = 68) and Salmonellosis (N = 54) as patients group and 204 healthy asymptomatic children as control group enrolled in this study. Results. The prevalence of H. pylori infection in healthy control children was significantly higher than in patients group, (odds ratio = 3.6, 95% CI: 1.33–9.5, P = 0.007). In our study, only 2/54 Salmonella infected patients and 3/68 of Shigellosis had evidence of H. pylori infection, while normal control children had 27/204 infected individuals. Conclusion. H. pylori infection may play a protective role against bacterial diarrhea in children. So it is important to consider all of the positive and negative aspects of H. pylori infection before its eradication.

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“…Today, the role of H. pylori infection is reported in many diseases, including idiopathic thrombocytopenic purpura [14], iron deficiency anaemia [15], and hepatic and cardiovascular symptoms and biliary tract disease [16,17]. Moreover, in some studies, the role of H. pylori in cirrhosis [18][19][20][21], hepatic encephalopathy [22,23], primary biliary cirrhosis [24], and bleeding oesophageal varices [25] is emphasised.…”

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and cirrhosis in children

Zahmatkeshan¹,

Matani²,

Asadian³

2019

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Introduction: Liver cirrhosis is often accompanied by fibrosis, loss of liver function, and liver cancer. Identification of the factors associated with this disease has always been a goal because they can be effective in its treatment. Several reports showed that Helicobacter pylori (H. pylori) can cause multiple gastrointestinal complications. Aim of the research: To investigate the association between H. pylori infection and liver cirrhosis in children. Material and methods: In this case-control study, 60 children under the age of 18 years with liver cirrhosis participated as the cases, and 236 healthy children were included as controls. For evaluation of the H. pylori antigen (Ag) of the samples, fresh stool samples were prepared. Results: Thirty-two (53.3%) samples in the cases, and 46 (19.5%) samples in controls had positive H. pylori Ag test. The results showed that the two groups had significant differences in terms of infection by H. pylori stool antigen; the presence of this Ag in the case samples was more than in the controls (p < 0.001). Conclusions: That the rate of H. pylori infection in children with cirrhosis was significantly higher than among healthy children. This result can indicate the effect of this bacterium on the incidence and development of liver cirrhosis. Streszczenie Wprowadzenie: Zwłóknienie, utrata funkcji wątroby, a także rak wątroby często towarzyszą marskości wątroby. Zawsze określano czynniki związane z marskością, ponieważ może się to okazać skutecznym podejściem w leczeniu. Wyniki szeregu badań wykazały, że Helicobacter pylori (H. pylori) może być przyczyną licznych powikłań żołądkowo-jelitowych. Cel pracy: Zbadanie związku między zakażeniem H. pylori i marskością wątroby u dzieci. Materiał i metody: W badaniu kliniczno-kontrolnym wzięło udział 60 dzieci w wieku do 18 lat (grupa badana) oraz 236 zdrowych dzieci (grupa kontrolna). Wykonano badanie próbek kału na obecność antygenu (Ag) H. pylori. Wyniki: Pozytywne wyniki na obecność antygenu H. pylori uzyskano w przypadku 32 (53,3%) próbek pochodzących od chorych dzieci i 46 (19,5%) próbek od grupy kontrolnej. Na podstawie wyników stwierdzono różnice między tymi grupami pod względem zakażenia H. pylori; wykazano większą częstość występowania antygenu w grupie badanej w porównaniu z grupą kontrolną (p < 0,001). Wnioski: Częstość występowania zakażenia H. pylori u dzieci chorych na marskość była istotnie większa niż w grupie zdrowych dzieci. Wynik ten wskazuje na wpływ bakterii na występowanie i rozwój marskości wątroby.

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Effect of Helicobacter pylori infection on esophagogastric variceal bleeding in patients with liver cirrhosis and portal hypertension

Abstract: These results suggest that H. pylori infection has a protective effect against esophagogastric variceal bleeding through the induction of gastric mucosal atrophy and concomitant hypoacidity.

Cited by 15 publications

References 49 publications

Impact of Helicobacter pylori Infection on Gastric Variceal Bleeding among Patients with Liver Cirrhosis

Impact of Helicobacter pylori Infection on Gastric Variceal Bleeding among Patients with Liver Cirrhosis

The Relation betweenHelicobacter pyloriInfection and Acute Bacterial Diarrhea in Children

Association between Helicobacter pylori infection and cirrhosis in children

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