Effect of <i>Sticophus hermanii</i> extract on fasting blood glucose and skeletal muscle glut4 on type 2 diabetes mellitus rats model

Safitri, Indri; Purwanto, Bambang; Rochyani, Linda; Prabowo, Gwenny Ichsan; Sukmaya, D

doi:10.1088/1755-1315/217/1/012025

Cited by 6 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saponins also play a role in increasing tyrosine phosphorylation from the insulin subunit β receptor, inhibiting tyrosine phosphatase, and stimulating glucose transport activities, such as GLUT 4. Increasing the amount of GLUT 4 represents an improvement in the hyperglycemia state in DM [5]. Increased glucose transport into cells as a form of improving hyperglycemia in DM would reduce lipolysis and released free fatty acids in the blood circulation so that LDL cholesterol levels decreased [9].…”

Section: Post-hoc Test Resultsmentioning

confidence: 99%

“…Golden sea cucumber powder was macerated by repeatedly stirring for 8 hours and soaked in 80% ethanol solution for 24 hours after which, 80% ethanol solution was collected, and gold sea cucumber pulp was mastered with 80% ethanol in the same way (total ethanol solution being used as much as 5.5 liters). The 80% ethanol solution obtained was evaporated with a water temperature of 50 °C until the ethanol solution evaporated and received a concentrated extract of 242.5 grams of golden sea cucumbers [5].…”

Section: The Production Of Golden Sea Cucumber Extractsmentioning

confidence: 99%

“…• 50 mg: 1000 grams x 175 grams = 8.75 mg/175gBW per injection. STZ was dissolved using citrate buffer pH 4.5 and then induced in intraperitoneal mice as much as 0.5 mL to each rat [5].…”

Section: Administration Of Stzmentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Golden Sea Cucumber (Stichopus hermanii) Extracts to Serum LDL Cholesterol level as a Result of Insulin Resistence

Setianingsih¹,

Putri

Desi

et al. 2020

IJMP

View full text Add to dashboard Cite

ABSTRACT Diabetes mellitus is a metabolic disease characterized by conditions of hyperglycemia as a result of abnormalities in the secretion of the insulin hormone, the work of the insulin hormone, or both. Metabolic disorders caused by diabetes cause lipolysis to increase, thereby increasing the level of VLDL, which will be converted to LDL. LDL disorders are the effects of insulin resistance. Streptozotocin (STZ) can increase serum LDL cholesterol serum levels due to the mechanism of ROS formation. Golden sea cucumber act as anti-hyperlipidemic because they contain EPA-DHA, saponins, and flavonoids. The purpose of these studies to determine the effect of Golden sea cucumber act as anti-hyperlipidemic. Experimental laboratory research is done using the post-test only control group design method. Using simple random sampling with 25 white male Wistar rats divided into five groups, all rats were given standard feeding. Group 1 without STZ induced, group 2-5 were induced STZ first, and then group 3-5 were given golden sea cucumber extract for 21 days with dose 4,25 mg/kg BW, 8,5 mg/kg BW, 12,75 mg/kg BW, per day respectively. At the end of the study, the LDL serum level was measured. The result of One – Way Anova test showed LDL cholesterol serum levels of group rats with STZ induction and given 12,75 mg/kg BW golden sea cucumber extracts (x=7,4 mg/dl) significantly decreased (p=0,005) compared to LDL cholesterol levels of group rats which were only induced by STZ without given golden sea cucumber extracts (x=12,6 mg/dl). This research showed that the administration 12,75mg/kg BW of golden sea cucumber extracts for 21 days reduced serum LDL cholesterol levels because golden sea cucumber contains compounds that work as antioxidants.

show abstract

Section: Post-hoc Test Resultsmentioning

confidence: 99%

Section: The Production Of Golden Sea Cucumber Extractsmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Golden Sea Cucumber (Stichopus hermanii) Extracts to Serum LDL Cholesterol level as a Result of Insulin Resistence

Setianingsih¹,

Putri

Desi

et al. 2020

IJMP

View full text Add to dashboard Cite

show abstract

“…Golden sea cucumber extract is added CMC-Na (Sodium Carboxymethyl Cellulose) until liquid. 13 Selection and manufacture of streptozotocin (STZ) solutions Streptozotocin (STZ) is a diabetogenic agent with toxic abilities that damages β cells. 14 The study was intended to create experimental diabetic conditions in male white rat (Rattus norvegicus) animals using the diabetogenic agent streptozotocin.…”

Section: Extract Preparationmentioning

confidence: 99%

Repairing of Renal Tubules in Diabetic Rats (Rattus norvegicus) Diabetes After Administration of Golden Sea Cucumber (Stichopus hermanii)

Setianingsih¹,

Wisnumarta²,

Tjandra³

2021

View full text Add to dashboard Cite

This study aims to analyze the improvement of the histopathological picture of renal tubules in diabetic rats after being given golden sea cucumber extract (Stichopus hermanii). This research uses experimental design laboratories with a post-test only control group design method. The sampling used simple random sampling with 25 white rats divided into five groups, namely groups that were given standard feed without STZ-induced, STZ-induced group, STZ-induced group and given golden sea cucumber extract at a dose of 4.25 mg/kg BW for 21 days, STZinduced group and given golden sea cucumber extract at a dose of 8.5 mg/kg BW for 21 days, and STZ-induced group and given gold sea cucumber extract at a dose of 12.75 mg/kg BW for 21 days. The data on the observation of each group's kidney histopathology was carried out at the end of the session. The results of the analysis using the Kruskal-Wallis Test showed significant results, the Mann-Whitney Test showed significant differences between the STZinduced group and the golden sea cucumber extract (Stichopus hermanii) dose of 12.75 mg/kg BW (x=7.4 mg/dl) decreased significantly (p=0.001) compared to the STZ-only-induced group (x=12.6 mg/dl). Administration of golden sea cucumber extract (Stichopus hermanii) at a dose of 12.75 mg/kg BW of rats for 21 days lowered the degree of tubular damage to the kidney rectus of white rats (Rattus norvegicus) male streptozotocin-induced strains.

show abstract

“…These extracts are acquired through an extraction process of using ethanol (maceration method). Based on the study of Safitri et al (2019), the extraction process is made through this process in which are: fresh Stichopus hermanni with a total mass of 9 kg, are cleansed then chopped into small pieces with a length of 3-10, then dried in the oven for 50 ° C until they are completely dried. Dried Sticophus hermanni would then be grinded using a blender and are made into a powdery form which would weight around 1,3 kg.…”

Section: B Golden Sea Cucumber (Stichopus Hermanii) Extractionmentioning

confidence: 99%

Mechanism of Pancreatic Islet Number Improvement on Hyperglycemic Wistar Rats (Rattus norvegicus) After Golden Sea Cucumber (Stichopus hermanii) Extract Administration

2020

IJITEE

View full text Add to dashboard Cite

Diabetes mellitus constitutes a metabolic disorder indicated by a decrease in insulin secretion, insulin insensitivity, or a combination of both. Golden sea cucumber (Stichopus hermanii) is a natural resource of Indonesian waters with benefit for reducing blood sugar levels. This research aimed to determine the anti-hyperglycemic mechanism of golden sea cucumber.This study used a experimental laboratory research with Post-test Only Control Group. The sample of this study consisted of 25 male rats aged 60-70 days, divided into 5 groups: K(-), K(+), P1, P2, and P3 randomly. Rats from K(+), P1, P2, and P3 groups were injected with streptozotocin (STZ) with a dose of 50 mg/kg BW. Treatment was administered for 21 days. K(-) and K(+) groups were fed normally while P1, P2 and P3 groups were given golden sea cucumber 80% ethanol extract with a dose of 4,25 mg/kgBW/day, 8,50 mg/kgBW/day and 12,75 mg/kgBW/day respectively. On the 22 nd day, fasting blood sugar level was measured and the number of pancreatic islet was counted with histopathological examination. The administration of golden sea cucumber (Stichopus hermanii) extract on rats with hyperglycemia does not reduce blood sugar level, but the extract administration increases the number of pancreatic islet. Golden sea cucumber (Stichopus hermanni) extract may improve the number of pancreatic islet and prevent the progressive damage of pancreatic islet.

show abstract

Effect of Sticophus hermanii extract on fasting blood glucose and skeletal muscle glut4 on type 2 diabetes mellitus rats model

Cited by 6 publications

References 9 publications

The Effect of Golden Sea Cucumber (Stichopus hermanii) Extracts to Serum LDL Cholesterol level as a Result of Insulin Resistence

The Effect of Golden Sea Cucumber (Stichopus hermanii) Extracts to Serum LDL Cholesterol level as a Result of Insulin Resistence

Repairing of Renal Tubules in Diabetic Rats (Rattus norvegicus) Diabetes After Administration of Golden Sea Cucumber (Stichopus hermanii)

Mechanism of Pancreatic Islet Number Improvement on Hyperglycemic Wistar Rats (Rattus norvegicus) After Golden Sea Cucumber (Stichopus hermanii) Extract Administration

Contact Info

Product

Resources

About