Effect ofVaccinium ashei readeLeaf Extracts on Lipid Metabolism in Obese OLETF Rats

Effect of dietary blueberry (Vaccinium ashei Reade) leaves on serum and hepatic lipid levels in rats

“…These authors found that the liver TG-lowering effect of BL might occur via reduced fatty acid synthesis and elevated fatty acid oxidation 22 . Using the same OLETF rats, Inoue et al also observed that feeding of the hot water extract of BL prepared following the same method as that of our BLHE alle-viates hepatic TG accumulation through enhanced lipolysis in the liver 28 . Thus, these observations suggest that the mechanism s responsible for the observed reduction in liver TG levels by dietary BL is, in part, due to both suppressive lipid synthesis and enhanced lipolysis and its oxidation, although clarification of these issues requires further studies.…”

“…In addition, the level required for the various physiological activities of dietary BL in the absence of dietary cholesterol is less than 3 . It is well known that dietary cholesterol markedly increases the concentration of serum and liver lipids in experimental animals 27,28 . As shown in Table 2, although dietary cholesterol significantly elevated both the serum and liver cholesterol levels, it appeared to influence liver TG levels in a reciprocal manner; thus, dietary cholesterol decreased serum TG levels but it caused an increase in the accumulation of liver TG.…”

“…In terms of liver TG-lowering activity, we found that oral administration of an aqueous extract of hydrothermal BL BLHE appeared to correspond to the extent of lipid-lowering activity observed after BL feeding, as shown in Table 1. Inoue et al 28 studied the effects of dietary hot water extract powder prepared from BL the same preparation as used in our study on lipid metabolism in obese OLETF rats. They found that feeding of this powder at the 2 level resulted in a significant decrease in the concentration of hepatic TG, indicating the usefulness of either administration of drinking or diet for the observed hepatic lipid-lowering effect.…”

14 Days of supplementation with blueberry extract shows anti-atherogenic properties and improves oxidative parameters in hypercholesterolemic rats model

“…These results suggest that BE and SIM exhibit similar lipid-lowering activity. Inoue et al (2011) investigated the effect of the BE leaves infusion on lipid profile and levels of hepatic triglycerides in obese rats. The data demonstrated that leaves extract showed a hypolipemic effect and the authors suggest that this effect may be related to the presence of proanthocyanidins and flavonoids in leaves.…”

Promising Plant Sources of Anti-Diabetic Micronutrients

“…Furthermore, consumption of the extract improved insulin sensitivity. An analysis of the effect of bilberry leaf aqueous extract and its fractions containing flavonol glycoside and proanthocyanidins on the lipid metabolism in OLETF rats suffering from obesity established that inclusion of bilberry leaf extract into the semi-synthetic diet of the animals (2% of the diet) for 4 weeks had resulted in a reduction of the lipid and C-reactive protein levels in the blood serum and a decrease in the accumulation of liver triglycerides [89,90]. Consumption of the flavonol glycoside and proanthocyanidin fractions resulted in an apparent reduction of cholesterol in the blood serum.…”