Effect of ibudilast on erythrocyte aggregability in patients with cerebral infarction

Tanahashi, N; Fukuuchi, Yasuo; Tomita, Maiko; Kobari, Masahiro; Takeda, Hidetaka; Yokoyama, M; Takao, Motoshi

doi:10.1016/0006-355x(96)84147-3

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“…The small num ber of subjects in this study limits exam ination of the potentially synergistic effects of hy pertension and diabetes on RBC-A or the possible role of RBC-A in differing subtypes of stroke. Although a recent report found no difference in RBC-A in subtypes of isch emic stroke, the more frequent association o f diabetes and hypertension with lacunar infarcts in large epidemi ological studies suggest that the results of this pilot study merit a wider examination of the potential involvement of elevated RBC-A in the development of microvascular infarcts [24],…”

Section: Discussionmentioning

confidence: 99%

Diabetes, Hypertension and Erythrocyte Aggregation in Acute Stroke

Beamer¹,

Giraud²,

Clark³

et al. 1997

Cerebrovasc Dis

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Elevated erythrocyte (RBC) aggregation (RBC-A) may contribute to the pathogenesis of stroke and stroke recurrence. We measured RBC-A at low shear in 55 patients with acute ischemic stroke and in 24 age-balanced controls without cerebrovascular disease or vascular risk factors. RBC-A was significantly elevated in subgroups of stroke patients who were hypertensive, diabetic, or both, compared with either stroke patients lacking these risk factors (p at least < 0.01) or healthy elderly (all p < 0.001). RBC-A was normal in stroke patients (n = 14) free of both diabetes and hypertension. In a multivariate linear regression model glycosylated hemoglobin (p < 0.0001), plasma viscosity (p < 0.006) and systolic blood pressure (p < 0.05) were each independently significant and together accounted for about 52% of the variation in RBC-A in acute stroke patients. No relationship was detected between RBC-A and infarct size or among the major subtypes of ischemic stroke. The results suggest that vigorous control of both blood glucose and blood pressure may reduce the potentially damaging effects of elevated RBC-A in the cerebral vasculature.

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Section: Discussionmentioning

confidence: 99%