Effect of ibuprofen and indomethacin on human plasma melatonin

Surrall, K. E.; Smith, J.A.; Bird, H. A.; Okala, B; Othman, Hemn Hassan; Padwick, D.

doi:10.1111/j.2042-7158.1987.tb05129.x

Cited by 22 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The physiology underlying indomethacin responsivity are still unknown. Theories proposed have included a drug‐related decrease in cerebral blood flow, reduction in cerebrovascular permeability, decrease in cerebrospinal fluid pressure, effect on melatonin pathway, and an antagonist effect on nitric oxide 6‐10 …”

Section: Commentsmentioning

confidence: 99%

Hemicrania Continua Responds to Cyclooxygenase‐2 Inhibitors

Peres

Silberstein

2002

Headache

View full text Add to dashboard Cite

show abstract

Section: Commentsmentioning

confidence: 99%

Hemicrania Continua Responds to Cyclooxygenase‐2 Inhibitors

Peres

Silberstein

2002

Headache

View full text Add to dashboard Cite

show abstract

“…1994), beta-blockers (Cowen et al 1985, and with respect to pain: anti-inflammatory drugs (Surrall et al 1987;Murphy et al 1994). Drugscreening in urine included benzodiazepines, barbiturates, cannabinoids, amphetamines, cocain and opiates.…”

Section: Study Populationmentioning

confidence: 99%

“…Special care was taken that subjects did not take any substances which are known to interfere with melatonin production and/or secretion, but which, among the general population, are sometimes not considered to be "medication," e.g., with respect to sleep: benzodiazepines (McIntyre et al 1988), antidepressants (Skene et al 1994), beta-blockers (Cowen et al 1985, and with respect to pain: anti-inflammatory drugs (Surrall et al 1987;Murphy et al 1994). Drugscreening in urine included benzodiazepines, barbiturates, cannabinoids, amphetamines, cocain and opiates.…”

Section: Study Populationmentioning

confidence: 99%

A New Concept for Melatonin Deficit On Pineal Calcification and Melatonin Excretion

Kunz

1999

Neuropsychopharmacology

139

102

View full text Add to dashboard Cite

Even though exogenous melatonin has proven to influence sleep and circadian parameters, low endogenous melatonin is not related to sleep disturbances, nor does it predict response to melatonin replacement therapy. In this manuscript, we present a new concept towards a definition of a melatonin deficit. The purpose of the study was to introduce a marker for an intra-individual decrease in melatonin production. Therefore, we developed a method to quantify the degree of pineal calcification (DOC) usingIn mammals, the circadian timing system has proven to be involved in the daily variation of almost any physiological and psychological variable evaluated so far (Weitzman et al. 1978;Wirz-Justice 1987;Johnson et al. 1992;Dijk and Czeisler 1995;Boivin et al. 1997). The rhythm of the circadian pacemaker comprised in the nuclei suprachiasmatici (SCN) becomes entrained to the environmental 24-hour rhythm, predominantly by two zeitgebers, light and melatonin (Dawson and Armstrong 1996).Melatonin influences the circadian phase in humans inversely compared to light. In particular, this drug delays circadian rhythms when administered in the morning and advances them when administered in the afternoon or early evening according to a phase response curve (PRC), which is nearly opposite in phase to the PRC's for light exposure (Lewy et al. 1992). Melatonin has proven to exert a chronobiotic mode of action (Dawson and Armstrong 1996) by its ability to facilitate the post-flight adaptation to jet-lag (Arendt et al. 1986), to phase advance the sleep of patients suffering from a phase-delay syndrome (Dahlitz et al. 1991;Tzischinsky et al. 1993), and to re-entrain the sleep-wake cycle of patients with a non-24-hour rhythm, such as in the blind, to the environmental light-dark cycle (Arendt et al. 1988;Lapierre and Dumont 1995;McArthur et al. 1996).However, in only one of the clinical studies (Haimov et al. 1995), in which exogenous melatonin proved usefulness, did low endogenous melatonin excretion predict response (Garfinkel et al. 1995;Hughes et al. 1998 Lushington et al. 1998;Youngstedt et al. 1998). Furthermore, normative data as to the amount of melatonin secretion demonstrate a huge inter-individual variability in humans (Dawson et al. 1992;Bergiannaki et al. 1995;Smith et al. 1997). Thus, existing normative data on melatonin excretion in a "healthy population" might only be considered normal in the sense that they are representative for the normal scatter. But since there is yet no pathology that can be attributed to either high or low melatonin levels, "normative" in this context may not necessarily indicate being healthy. The question arises, does a melatonin deficit or a hypopinealism exist at all?In a previously reported pilot-study we showed that the degree of pineal calcification (DOC) correlated positively to the incidence of chronic daytime tiredness as well as the subjective perception of sleep disturbances (Kunz et al. 1998). The basic assumption in that study was the hypothesis that an increasing degree of pineal c...

show abstract

“…Thus, NSAIDS have the ability to reduce melatonin synthesis. For example, it has been shown that NSAIDs such as aspirin (Murphy et al, 1986) and ibuprofen (Surrall et al, 1987;Murphy et al, 1986) reduce melatonin synthesis in humans. However, in the present study, tolmetin, but not sulindac, increases the amount of melatonin produced by the rat pineal gland.…”

Section: Discussionmentioning

confidence: 98%