This study examined the effects of combined anti-inflammatories and specific nutrients on recovery from resistance exercises. Trained individuals (n = 14) performed three sets to failure at a 8-12 repetition maximum load for six resistance exercises, then repeated this workout after 24 h. Participants consumed a protein-carbohydrate shake (330 ml; 20 g protein; 45 g carbohydrate), vitamin C (1000 mg), vitamin E (400 I.U.) and ibuprofen (100 mg) immediately after the initial workout. Another dose of vitamin C and ibuprofen were respectively consumed 1 h or 30 min before the second workout. On another occasion (counterbalanced) a placebo of flavored water, two imitation vitamins (gummy candies), and two replica ibuprofen (sugar pills) were consumed. A 10-cm visual analog scale (VAS) assessed pain, ratings of perceived exertion (RPE), and ratings of perceived recovery (RPR). Treatment enhanced performance-based recovery (repetitions after 24h) for the chest press (P < 0.010) and latissimus pull-down (P < 0.010). Within-condition comparisons revealed performance decrements (P < 0.050) after 24 h for 83% of the exercises under placebo, compared to 50% of exercises under treatment. Treatment enhanced RPR (P = 0.038) compared to placebo, but had no significant effects on residual (P = 0.215) or exercise (P > 0.050) pain. RPE was lower under the treatment for the chest press (P = 0.016) and overall workout (P = 0.038) on Day 1, but similar among all exercises on Day 2 (P > 0.050). This treatment may promote increases in performance without increasing pain or RPE.