Effect of icariin on bone formation during distraction osteogenesis in the rabbit mandible

Wei, Han; Zili, L.; Yuanlu, C.; Bu, Yi; Cheng, Liang; Xiaoxia, W.; Yang, Lei; Xing, Weirong

doi:10.1016/j.ijom.2010.10.015

Cited by 33 publications

(31 citation statements)

References 31 publications

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“…108 The osteoprotective effects were also compared among different 109 ingredients in Herba Epimedii. Icariin showed a stronger effect than 110 those of epimedin B and epimedin C to promote proliferation of 111 UMR106 cells [73].…”

mentioning

confidence: 99%

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

et al. 2015

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mentioning

confidence: 99%

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

et al. 2015

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“…However, such usual models impose several restrictions on translational studies, since these bones have different origins compared to the jaw (first arch) and possess a lower cortical-medullary thickness, thereby interfering with adequate bone-implant contact 13 . For a more realistic surgical applicability, the in-vivo model must include the tooth alveolus as an anatomical cavity.…”

Section: Discussionmentioning

confidence: 99%

In-vivo bone response to titanium screw implants anodized in sodium sulfate

Pinheiro

Mourão

Diniz³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the early bone response to a nanotextured dental implant treated with sodium sulfate (Na 2 SO 4 ), using a rabbit model. METHODS:Twelve animals were randomly divided into group 1 (Control) -machined implants and group 2 (Test) -nanotextured implants. Extra-oral incision was performed to provide access to intended surgical site where the dental implant was inserted immediately after the extraction of the mandibular first premolar. Implant surface characterization was performed by scanning electron microscopy attached to energy dispersive spectroscopy and interferometry. Three weeks after surgery, the animals were induced to death and undecalcified sections of the samples were prepared for histological and histomorphometrical analysis. RESULTS:Surface characterization of the implant demonstrated enhanced surface area of anodized group compared to Control group with 19.2% ± 6.2 versus 1.6 ± 0.7, respectively. Histological evaluation demonstrated new bone formation starting from the buccal and lingual cortical walls on both groups. After three weeks, significant higher bone contact of 27% (p<0.05) was observed to nanotextured compared to machined implants (Control group). CONCLUSION:The anodization with sodium sulfate nanostructures to the implant surface that resulted in faster osseointegration.

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“…During embryonic development, the jaw bone is the second to be formed, whose origin is from the first gill arch, with a background different from the other bones of the body 16 . The fact of using bone grafts, allografts, xenografts and alloplastic several bones as the tibia, femur and calvaria 2,[8][9][10][11][17][18][19] away from the area of work in dentistry, which is why the choice of jaw for use in a model for application of biomaterials.…”

Section: Discussionmentioning

confidence: 99%

Molars extraction for bone graft study in rabbits

Manso¹,

Mourão²,

Pinheiro³

et al. 2011

Acta Cir. Bras.

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PURPOSE: The aim of this study was to describe an experimental surgical technique to be used in the evaluation of bone grafts in rabbits. METHODS: The operative technique was performed in jaws, with external approach from the labial commissure to the last molar tooth. An incision about 1cm extended forward to the alveolar ridge, followed by a exposing the cervical region of the alveolar bone and dental elements was done. Thus, after extraction of first molar with forceps, the tooth socket left was filled with hydroxyapatite. The bone gain was analyzed by histopathological studies. RESULTS: The histological analyses indicated formed bone surrounding the biomaterial. CONCLUSION: The experimental model using the tooth socket of the rabbit molar is a feasible procedure for studies of bone grafts.

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Effect of icariin on bone formation during distraction osteogenesis in the rabbit mandible

Cited by 33 publications

References 31 publications

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

In-vivo bone response to titanium screw implants anodized in sodium sulfate

Molars extraction for bone graft study in rabbits

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