Effect of Imidacloprid on Reproduction of Female Albino Rats in Three Generation Study

Vohra, Prerna; Khera, Kuldeep Singh

doi:10.4172/2157-7579.1000340

Cited by 11 publications

(19 citation statements)

References 21 publications

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“…41,42 Exposure to environmental toxicants, for example, acrylamide, bisphenol, tetrabromobisphenol A, and imidacloprid, brought variations in growth and endocrine functions and thus affected F1 and F2 generations. 23,30,36,43 It has been previously reported that exposure of furan caused reproductive toxicity in several animal studies. 5,16 Guo et al reported that young men prenatally exposed to dioxins and furan have a high incidence of abnormal sperm morphology, motility, and reduced ability to penetrate hamster ovary.…”

Section: Discussionmentioning

confidence: 99%

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Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

et al. 2020

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The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg−1 for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg−1 and 10 mg kg−1), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg−1. Number of live pups at birth were decreased ( p < 0.001) at 10 mg kg−1. At postnatal day (PND) 70, a significant ( p = 0.03) decrease in testosterone levels of male rats and estrogen levels of female rats ( p = 0.05) was observed in 10 mg kg−1 furan-treated group in F1 generation. Luteinizing hormone, follicle-stimulating hormone, and progesterone levels were also reduced, but their reduction was not statistically significant in all groups. In higher dose furan group (10 mg kg−1), testicular and ovarian weights were reduced in F1 generation at PND 70, with decreased daily sperm production ( p = 0.01) and disturbed estrous cyclicity ( p < 0.01). Some histopathological changes were also observed in testis and ovaries in groups whose parents were previously exposed to 10 mg kg−1 bw of furan group. Based on the above results, it is suggested that exposure to food-based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats.

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Section: Discussionmentioning

confidence: 99%

“…50 In our study, reduction in gestational weight gain may be due to the reason that lactation makes greater demand of mother's body than pregnancy does. 43 Another possible reason is low number of implantation sites during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

et al. 2020

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“…However, the authors found decreased body weight in mother rats and male and female offspring that was associated with reduced food consumption at dietary imidacloprid dose of 700 ppm (corresponding to 47 mg kg -1 bw day -1 ). In a three-generation reproductive study (28) oral administration of 20 mg kg -1 bw day -1 of imidacloprid affected body weight and food consumption and caused only minimal effects on the reproductive performance such as reduction in fertility index in the second and third generation.…”

Section: =First/second Generation Of Offspring; Fsh=follicular Stimumentioning

confidence: 97%

“…Studies conducted in male and female laboratory animals, mostly rats, have established that oral administration of imidacloprid could affect reproductive function, as summarised in Table 1 (20)(21)(22)(23)(24)(25)(26)(27)(28). Subchronic and chronic exposure to different doses of imidacloprid can cause histological damage of the testicular tissue, changes in sperm morphology, increased sperm mortality and abnormality, decreased sperm count and motility, inhibited spermatogenesis, and reduced testosterone levels in male rats, all of which could lead to infertility (20)(21)(22)(23)(24).…”

Section: Reproductive Toxicitymentioning

confidence: 99%

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Mikolić

Karačonji

2018

Archives of Industrial Hygiene and Toxicology

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Imidacloprid, a neonicotinoid insecticide, has been used worldwide due to its selective toxicity for insects. Its residues may enter the food chain, which is why it is important to investigate the potential adverse effects of imidacloprid exposure. This review summarises current knowledge of the reproductive toxicity and disruptive endocrine effects of imidacloprid in laboratory animals. Investigations, conducted mostly on laboratory rats, have shown adverse effects of imidacloprid on the reproductive ability in both parental and offspring generation as well as on the development of the offspring. Like many pesticides, imidacloprid may also act as endocrine disrupting chemical (EDC). It may disrupt the metabolic homeostasis, contribute to obesity, and disrupt steroidogenesis by inhibiting cytochrome P450 (CYP) enzyme activities. All these adverse effects of imidacloprid may pose a serious risk for reproduction and development with long-term consequences in adulthood.

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“…As stated previously, imidacloprid has been shown to decrease FT4 levels in other vertebrates 49 – 51 . Additionally, research on rats has shown that organ weights (specifically liver and spleen) decrease as imidacloprid treatment increases 54 – 56 . From our observations and previous research, we predict that imidacloprid is suppressing the immune function and size of the spleen.…”

Section: Discussionmentioning

confidence: 99%

Effects of Neonicotinoid Insecticides on Physiology and Reproductive Characteristics of Captive Female and Fawn White-tailed Deer

Berheim

Jenks

Lundgren

et al. 2019

Sci Rep

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Over the past decade, abnormalities have been documented in white-tailed deer (Odocoileus virginianus) in west-central Montana. Hypotheses proposed to explain these anomalies included contact with endocrine disrupting pesticides, such as imidacloprid. We evaluated the effects of imidacloprid experimentally at the South Dakota State University Wildlife and Fisheries Captive Facility where adult white-tailed deer females and their fawns were administered aqueous imidacloprid (an untreated control, 1,500 ng/L, 3,000 ng/L, and 15,000 ng/L). Water consumption, thyroid hormone function, behavioral responses, and skull and jawbone measurements were compared among treatments. Additionally, liver, spleen, genital, and brain imidacloprid concentrations were determined by an enzyme-linked immunosorbent assay (ELISA). Results indicated that 1) control deer consumed more water than treatment groups, 2) imidacloprid was present in the organs of our control group, indicating environmental contamination, 3) as imidacloprid increased in the spleen, fawn survival, thyroxine levels, jawbone lengths, body weight, and organ weights decreased, 4) adult female imidacloprid levels in the genitals were negatively correlated with genital organ weight and, 5) behavioral observations indicated that imidacloprid levels in spleens were negatively correlated with activity levels in adult females and fawns. Results demonstrate that imidacloprid has direct effects on white-tailed deer when administered at field–relevant doses.

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Effect of Imidacloprid on Reproduction of Female Albino Rats in Three Generation Study

Cited by 11 publications

References 21 publications

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Effects of Neonicotinoid Insecticides on Physiology and Reproductive Characteristics of Captive Female and Fawn White-tailed Deer

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