Effect of Imidafenacin on Nocturia and Sleep Disorder in Patients with Overactive Bladder

Abstract

Objective: To evaluate the efficacy of imidafenacin on nocturia and sleep disorder in patients with overactive bladder (OAB). Patients and Methods: A prospective multicenter study of imidafenacin 0.1 mg twice daily for patients with OAB and nocturia was conducted. At baseline and at week 4 and 8, patients were assessed using the overactive bladder symptom score (OABSS), frequency volume charts (FVC) and the Pittsburgh Sleep Quality Index (PSQI). Results: Treatment with imidafenacin significantly improved OAB symptoms. Imidafenacin also improved PSQI, especially subjective sleep quality, sleep latency and daytime dysfunction. In FVC, the number of daytime voids and nighttime voids significantly decreased and average voided volume significantly increased after imidafenacin. Subanalysis of FVC based on the patients’ age revealed that nocturnal polyuria was more often found in patients aged 75 years or over than in those aged under 75 years (79 vs. 55%, p < 0.05). Treatment with imidafenacin significantly reduced the nocturnal polyuria index only in patients aged 75 years or over. Conclusions: Imidafenacin can improve nocturia and sleep disorder in patients with OAB. The efficacy of imidafenacin on nocturia is attributable to an increase in bladder capacity and a decrease in nocturnal urine volume. We conclude that imidafenacin is an effective and safe drug for nocturia in patients with OAB.

Comprehensive Health-Related Quality of Life is Influenced by Nocturia and Sleep Disturbance: Investigation Based on the SF-8

“…Moreover, HRQOL was improved according to the SF-8 (PCS and MCS), which revealed either significant improvement or a tendency for improvement from 8 weeks. Similar findings have recently been reported by Nagaoka et al [26] and Wada et al [27], who concluded that imidafenacin can be useful for the treatment of nocturia, sleep disturbance, and HRQOL.…”

Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder

“…[4] Furthermore, OABSS is useful for determining the effect of treatment on urinary disorders. [89] In this study, we investigated the effect of pumpkin seed oil from C. maxima by OABSS. The OABSS was remarkably reduced in subjects given pumpkin seed oil extracted from C. maxima .…”

Long-term safety, efficacy, and tolerability of imidafenacin in the treatment of overactive bladder: a review of the Japanese literature

“…Thus, both sleep disorders and nocturia-related quality of life were improved by imidafenacin in patients with OAB and nocturia. Wada et al further demonstrated that imidafenacin for 8 weeks improved the PSQI, especially subjective sleep quality, sleep latency, and daytime dysfunction, in 26 patients with sleep disorders at baseline 39. Interestingly, they observed that imidafenacin significantly reduced the nocturnal polyuria index from 0.48 ± 0.11 to 0.43 ± 0.14 ( P < 0.05) as a result of a significant decrease in nocturnal urine volume from 888 ± 286 mL to 795 ± 294 mL ( P < 0.05) in 40 patients with nocturnal polyuria, although the mechanism involved remains unknown.…”