The effect of lectins (phytohemagglutimn -PHA, concanavalin A -ConA, Pisum sativum lectin -PSL, Ricinus cornmunis lectin -RCL, and pokeweed mitogen -PWM) on the cardiac cholinoceptors is studied in experiments on isolated hearts of male Rana temporaria frogs. The test lectins in concentrations from 10 .23 to 10 -3 are shown to exhibit cholmomimetic properties.