Effect of Immunosuppression on Target Blood Immune Cells Within 1 Year After Lung Transplantation: Influence of Age on T Lymphocytes

Abstract

BackgroundLymphocytes are targeted by immunosuppressive therapy in solid organ transplantation and they influence allograft outcome.Material/MethodsPeripheral blood lymphocyte subsets (PBLS) determined by flow cytometry during the first year post-transplant from patients who underwent a first lung transplantation in a French University Hospital between December 2011 and July 2013 were retrospectively analyzed according to recipient characteristics and allograft outcome.ResultsFifty-seven recipients were enrolled and 890 PBLS were collected. T lymphocytes and NK cells were rapidly decreased, below normal range, from the first postoperative days. B cells decreased more gradually, remaining within normal range, with the lowest level reached after day 100. In multivariate analysis, greater T lymphopenia was found in older recipients (−414 [−709 to −119] cells/μL, p=0.007). According to the outcome, multivariate analysis evidenced lower levels of lymphocytes when bacterial and viral infection occurred (−177 [−310 to −44] cells/μL, p=0.009 and (−601 [−984 to −218] cells/μL, p=0.002, respectively), higher CD8+ T lymphocytes with BOS (+324 [+94 to +553] cells/μL, p=0.006), and higher leukocytes with restrictive allograft syndrome (+3770 [+418 to +7122] cells/μL, p=0.028).ConclusionsAging is associated in our cohort with more severe T lymphopenia after induction therapy for lung transplantation. The analysis of leukocytes and PBLS is associated with specific profile according to the allograft outcome.

Prophylactic vaccination with a live-attenuated herpes zoster vaccine in lung transplant candidates

“…In vaccinated patients who underwent lung transplantation, VZV IgG concentrations declined starting at 1 month after transplantation, but they were still higher than at baseline levels during the follow-up period, in contrast to the relatively stable level in unvaccinated patients who underwent transplantation. 29 Lowest VZV SFCs levels were seen at 1 month after transplantation in both groups, and this could be due to the strong effects of short-term immunosuppressants, which target T lymphocytes. VZV-specific CMI returned to a high level after a median time of 7.3 months after transplantation.…”

Age–related difference of substances controlling mitoses in lymph is a new way of drugs design and development

“…It is known that mitosis is age-related process as well as other components of immune system. [33][34][35] It was posited that a combination of adjuvantation systems may provide enhanced immune activation but has typically been developed without regard to the age of the target population and distinct combinations of TLRAs and C-type lectin receptor agonists may enhance Th1 responses of newborn DCs. Neutrophils, monocyte/macrophages and dendritic cells, which first recognize and respond to infection, show age-related impairment of many functions relevant to anti-viral responses.…”

Influences of 6-furfuryloaminopurine on Peripheral T Lymphocyte Subpopulations and Apoptosis of Thymus Lymphocytes of Aging Rats

“…There was a positive correlation between the number of lymphocytes and the immunity of the body (Dar et al, 2018, Argente et al, 2019. With the aging of body, The amount of T cells declines and the immune decline (Chason et al, 2018).The number and subpopulations of T cells in peripheral blood also change which results in the decrease of CD 3 + 0CD 4 + and CD 8 + T cells (Coiffard et al, 2018, Ilienko et al, 2017, Sanderson and Simon, 2017. Our study also found peripheral CD 3 + 0CD 4 + and CD 8 + T cells significantly decreased in the aging rats compared to the young control rats.…”