Effect of impaired vasa vasorum flow on the structure and mechanics of the thoracic aorta: implications for the pathogenesis of aortic dissection

Angouras, Dimitrios C.; Sokolis, Dimitrios P.; Dosios, Theodosios; Kostomitsopoulos, Nikolaos; Boudoulas, Harisios; Skalkeas, G; Karayannacos, Panayotis E.

doi:10.1016/s1010-7940(00)00382-1

Cited by 133 publications

(107 citation statements)

References 11 publications

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“…The values obtained showed that the subrenal aortas exhibited a loading stiff ening characterized an increased Young's modulus for large deformations with respect to the Young's modulus for smaller deformations, similar to the thoracic aorta of pigs described in Angouras et al 2 . This progressive stiff ening due to the increasing load is typical for soft tissues such as tendon, high fascia, skin, ligament, arteries, and aorta 3,9,[18][19][20][21] .…”

Section: Discussionsupporting

confidence: 81%

Morphology and Mechanical Properties of the Subrenal Aorta in Normotensive and Hypertensive Rats

Kochová¹,

Tonar²,

Matějka³

et al. 2008

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims: This work focuses on the morphological and mechanical changes in the wall of the subrenal aorta in rats suff ering from arterial hypertension and chronic renal failure induced by subtotal nephrectomy (NX).Methods: The quantitative structural parameters were assessed using stereological methods. The mechanical properties were determined using uniaxial tensile tests.Results: Morphological results showed no signifi cant diff erences in the wall structure of NX rats ten days following the subtotal nephrectomy in comparison with the control animals. Pronounced structural changes appeared ten weeks after the nephrectomy. The area of the profi le of the arterial lumen, the volume fraction of elastin, and the elastin lamellar number in the tunica media were signifi cantly higher in the NX rats than in the control animals. The values of the volume fraction of the smooth muscle cells in the tunica media and the lamellar unit thickness were signifi cantly lower for the NX animals. Mechanical results showed that both kinds of tissues were characterized by a non-linear response when subjected to the tensile test. The moduli of elasticity of subrenal aortas in control and NX animals were diff erent only for large deformations: NX samples had higher stiff ness. The cyclic loading resulted in a time-dependent response for both tissue types. Conclusions:The results obtained from the NX rats ten days as well as ten weeks after operation suggested an outward hypertrophy of the aorta. The subrenal aortas of the NX animals had less strength and were less extensible than those of the control animals.

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Section: Discussionsupporting

confidence: 81%

Morphology and Mechanical Properties of the Subrenal Aorta in Normotensive and Hypertensive Rats

Kochová¹,

Tonar²,

Matějka³

et al. 2008

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Unlike the findings reported in the study by Angouras et al 15 and Stefanadis et al 11 , our study demonstrated the presence of subendothelial fibrosis with a mild inflammatory infiltrate of lymphocytes and neutrophils at the outermost part of the media, as well as sparse foci of angiogenesis in the outer layer, since two weeks after injury.…”

Section: Fagundes Fagundes Fagundes Fagundes Fagundescontrasting

confidence: 96%

“…Stefanadis et al 11 also demonstrated, besides the breakdown of collagen and elastin fibers, an increase in the stiffness of the ascending aorta in dogs two weeks after the removal of the VV. These results were confirmed latter by the work of Angouras et al 15 , who studied the morphological alterations secondary to interruption of VV by removing the adventitia of the descending thoracic aorta in pigs. After two weeks, ischemia of the aortic wall led to morphological alterations in the content of collagen and elastin in the outer third of the media, resulting in stiffening in this region.…”

Section: Fagundes Fagundes Fagundes Fagundes Fagundessupporting

confidence: 72%

Efeitos da remoção da túnica adventícia da aorta descendente em suínos

Fagundes¹,

Pereira

Correa

et al. 2012

Rev. Col. Bras. Cir.

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OBJETIVO: Investigar os efeitos da remoção da adventícia da aorta em suínos. MÉTODOS: O experimento foi realizado com oito suínos. Removeu-se a camada adventícia da aorta descendente. Após a eutanásia com duas, quatro, seis e oito semanas, o segmento aórtico era removido. Após, eram feitos cortes histológicos com a coloração de hematoxilina e eosina (HE) e pelo método de Weigert - Van Gieson. RESULTADOS: Após duas semanas identificou-se um leve desarranjo do terço externo da túnica média. Nos animais sacrificados após quatro semanas observou-se um desarranjo estrutural dos terços externos da túnica média. Após seis semanas observou-se necrose da parede aórtica. Finalmente, após oito semanas além da fibrose da parede aórtica identificou-se a destruição da lâmina elástica interna. CONCLUSÃO: A remoção da adventícia da aorta em suínos levou à alterações degenerativas da média, determinando perda da estrutura da parede aórtica que é variável em sua localização, intensidade e forma, dependendo do tempo a partir do qual se estabeleceu a lesão isquêmica.

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“…Earlier studies mainly involved aortae and used serial histological sections (Nakata et al, 1977;Heistad et al, 1978;Stefanadis et al, 1995;Angouras et al, 2000). This approach made it difficult to accurately deduce the 3D architecture of the vasa vasorum and to clearly distinguish the three types of vasa vasorum.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have described the vasa vasorum; however, some of these descriptions were mostly qualitative (Winternitz et al, 1938;Schoenenberger and Mueller, 1960) and others were based largely on histological sections of the vascular walls in which the vasa vasorum are found (Nakata et al, 1977;Stefanadis et al, 1995;Angouras et al, 2000). The detailed architecture of the vasa vasorum networknamely its three-dimensional (3D) layout within the vascular wall, and its hierarchical branching structure and vascular geometry-has not yet been described because of a lack of data, and because of methodological difficulties in obtaining such data.…”

mentioning

confidence: 99%

Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries

et al. 2003

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In this study vasa vasorum in the walls of porcine coronary arteries were examined, using three-dimensional (3D) micro-CT scanning techniques. These techniques leave the 3D structure of the vasa vasorum tree intact and thus provide a much more direct view of this structure than is possible from conventional histological sections. The study demonstrates-for the first time, we believe-both the different types and the fine architecture of these vasa vasorum. Furthermore, with the use of automated tree analysis software, it was possible to obtain quantitative geometrical data on the 3D structure of vasa vasorum trees that have not previously been available. The results indicate that despite the restrictive topology of the space in which they are present, the branching architecture of the vasa vasorum trees, which we surveyed, is surprisingly similar to that of vasculature in general. The volume of vessel wall tissue perfused or drained by a vasa vasorum tree was found to correlate well with the cross-sectional area of the root segment of the vasa vasorum tree, and the luminal surface area corresponding to this volume was found to be comparable with the surface area of an early atherosclerotic lesion. This is consistent with earlier findings that the ligation or removal of vasa vasorum leads to atherogenesis. Anat Rec Part A 272A: 526 -537, 2003. Published 2003 Key words: vasa vasorum; vessel wall perfusion; vascular branching structure; vascular diseaseThe vasa vasorum have been the subject of considerable interest for more than a century (Koester, 1876), first because of their peculiar function (namely that of supplying blood to the walls of blood vessels), and second because of their possible role in atherogenesis

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Effect of impaired vasa vasorum flow on the structure and mechanics of the thoracic aorta: implications for the pathogenesis of aortic dissection

Cited by 133 publications

References 11 publications

Morphology and Mechanical Properties of the Subrenal Aorta in Normotensive and Hypertensive Rats

Morphology and Mechanical Properties of the Subrenal Aorta in Normotensive and Hypertensive Rats

Efeitos da remoção da túnica adventícia da aorta descendente em suínos

Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries

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