Effect of in-office desensitizers containing calcium and phosphate on dentin permeability and tubule occlusion

Machado, Alana Cristina; Rabelo, Fernanda Ellen Mercatelli; Maximiano, Vinícius; Lopes, Raquel Marianna; Aranha, Ana Cecília Corrêa; Scaramucci, Taís

doi:10.1016/j.jdent.2019.05.025

Cited by 32 publications

(42 citation statements)

References 34 publications

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“…This mechanism could explain a non-statistical increase of VAS values after 12 weeks in comparison to the previous check points. This consideration could be corroborated by in vitro observations, which reported that the TD layer could be partially affected by erosion-abrasion cycling over time [30]. However, also in this case, the exposure of dentine areas did not produce a statistically different reduction of hydraulic conductance, in comparison to non-stressed controls.…”

Section: Discussionsupporting

confidence: 73%

“…Furthermore, a high reactivity with moisture and slow hardening reported in premixed compounds [23] could have caused an easy detachment from the surface of dentine, explaining the VAS increase within the four-week exposure. In addition, the stability of values recorded at 12 and 24 weeks could further support the long time span required by the material to form firm crystal tubular plugs in salivary fluids [30].…”

Section: Discussionmentioning

confidence: 72%

“…To explain the clinical behaviour of TD in DH, we can match our data to those reported in several in vitro analyses, which tested the capacity of the agent simulating the oral stress and chemical and mechanical interferences [20,23,30]. However, none of the published papers evaluated the material for more than four weeks.…”

Section: Discussionmentioning

confidence: 91%

“…After one week and four weeks in artificial saliva, the Ca-P-rich layer demonstrated the presence of crystallites and crystal plugs into the dentinal tubules [20,24], being deeply integrated into the dentinal tissue, even when ultrasonication was used [18]. We could adopt the same considerations to explain the capacity of TD to firmly reduce the pain within 4 weeks of oral exposure [20,24,30]. TD has faster setting and hardening in addition to high shear resistance in the laboratory, which is related to its TTCP and DCPD composition [23].…”

Section: Discussionmentioning

confidence: 91%

“…As a consequence of the different behaviour, statistical differences were found between the agents within the time span of this experiment, even if at the last check point all of the materials had lower capacity in reducing DH values in comparison to that observed in Pre-1. Data could be interpreted following their composition and then the ability to harden on the exposed surface and resist chemical and physical challenges with stable remineralisation of the tubules [19,29,30].…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation

et al. 2019

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Background: Calcium phosphate-based compounds are used to treat dental hypersensitivity (DH). Their long-term clinical behaviour needs further research. This study compared the 24-week effectiveness of Teethmate Desensitizer (TD), a pure tetracalcium phosphate (TTCP) and dicalcium phosphate dihydrate (DCPD) powder/water, to that of Dentin Desensitizer (DD), and Bite & White ExSense (BWE), both of calcium phosphate crystallites. Methods: A total of 105 subjects were selected. A random table was utilised to form three groups of 35 subjects. DH was evaluated using the evaporative sensitivity, tactile sensitivity tests, and the visual analogue scale (VAS) of pain. Response was recorded before the application of the materials (Pre-1), immediately after (Post-0), at 1 week (Post-1), 4 weeks (Post-2), 12 weeks (Post-3) and 24 weeks (Post-4). The non-parametric distribution was assessed with the Shapiro–Wilk statistical test. Intra-group differences for the six time points were evaluated with the Friedman statistical test and the Kruskal–Wallis test. Results: All the materials decreased DH after 24 weeks in comparison to Pre-1. However, the TTCP/DCPD cement showed the greatest statistical efficiency. Conclusions: The significant decrease of VAS scores produced by TD in the long term suggest the material as the most reliable in the clinical relief of DH.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation

et al. 2019

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Effect of a modified adhesive system with encapsulated arginine and calcium carbonate on dentin permeability

et al. 2023

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To modify an adhesive system with halloysite clay nanotubes (HNTs) containing arginine and calcium carbonate and to evaluate their cytocompatibility, viscosity and efficacy in reducing dentin permeability. HNTs containing arginine and calcium carbonate were incorporated into the primer and adhesive of a three‐step adhesive system (SBMP), and their viscosity was measured. Discs (n = 4/group) were prepared: SBMP (control), HNT‐PR (modified primer), HNT‐ADH (modified adhesive) and HNT‐PR + ADH (modified primer and adhesive) were evaluated regarding cell death and viability. Dentin discs were prepared and randomly assigned into the following treatments (n = 10): NC (no treatment), SBMP, HNT‐PR, HNT‐ADH, HNT‐PR + ADH and COL (Colgate® Sensitive Pro‐relief™ prophylaxis paste). After, they were submitted to an erosive‐abrasive cycling. Dentin permeability (hydraulic conductance) was evaluated at baseline, 24 h after treatment and after cycling. Both the modified primer and adhesive showed significantly higher viscosity than their controls. Group HNT‐PR resulted in significantly higher cytotoxicity when compared to SBMP and HNT‐PR + ADH groups. Group HNT‐ADH resulted in the highest cell viability compared to all other groups. All groups showed significantly lower dentin permeability when compared to the NC group. Post‐cycling, SBMP and HNT‐ADH groups showed significantly lower permeability when compared to COL group. The addition of encapsulated arginine and calcium carbonate did not affect the cytocompatibility of the materials nor their ability to reduce dentin permeability.

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Chemical and mechanical resistance of novel experimental hybrid coatings on dentin permeability

Oliveira

Anágua-Bravo

Aoki

et al. 2020

Microscopy Res & Technique

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This study aimed to evaluate the capacity of novel experimental hybrid coatings (HC) to reduce dentin permeability and to verify their resistance to erosive and abrasive challenges. Dentin disc specimens (1 mm thick) were treated with 0.5 M EDTA solution and randomly allocated into three experimental groups (n = 10): Control (Saliva); Concentrated Hybrid Coating (TEOS/GPTMS/Y‐APS); and Diluted Hybrid Coating (1:3 ratio with distilled water). Dentin permeability was assessed by hydraulic conductance in the following experimental time periods: post‐EDTA, post treatment, post erosion (5 min in 0.05 M citric acid solution, pH = 3.8), and post abrasion (toothbrushing for 3,900 cycles). Dentin permeability percent was calculated with respect the values of post‐EDTA for each experimental time. The morphology of the surface of extra dentin specimens was examined by scanning electron microscopy (SEM) in the same time periods (n = 3). Permeability data were analyzed by two‐way repeated measures ANOVA and Tukey tests (p < .05). Both HC presented significantly lower dentin permeability than control post treatment and post erosion (p < .05), without difference between them (p > .05). Post abrasion, there were no significant difference among groups (p > .05). Post treatment and post erosion, the HC seemed to flow into the tubules, occluding them, while the tubules in control remained opened. Post abrasion, the tubules appear to be occluded in all groups. In conclusion, the experimental hybrid coatings were capable of reducing dentin permeability after treatment. They were also able to resist to erosive and abrasive challenges, with the advantage of forming thinner and colorless films that can be potentially used to treat dentin hypersensitivity.

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Effect of in-office desensitizers containing calcium and phosphate on dentin permeability and tubule occlusion

Cited by 32 publications

References 34 publications

Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation

Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation

Effect of a modified adhesive system with encapsulated arginine and calcium carbonate on dentin permeability

Chemical and mechanical resistance of novel experimental hybrid coatings on dentin permeability

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