Effect of Inadequate Empiric Antibacterial Therapy on Hospital Outcomes in SARS-CoV-2-Positive and -Negative US Patients With a Positive Bacterial Culture: A Multicenter Evaluation From March to November 2020

Puzniak, Laura; Bauer, Karri A.; Moise, Pamela A.; Finelli, Lyn; Ye, Gang; Anda, Carisa De; Vankeepuram, Latha; Gupta, Vikas

doi:10.1093/ofid/ofab232

Cited by 18 publications

(14 citation statements)

References 31 publications

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“…It’s vital to emphasize that these outcomes are primarily influenced by bacterial infections rather than viral ones. 244 …”

Section: Pneumonia and Covid-19mentioning

confidence: 99%

Treatment and Management of Acinetobacter Pneumonia: Lessons Learned from Recent World Event

Rangel,

De-Simone

2024

IDR

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Acinetobacter pneumonia is a significant healthcare-associated infection that poses a considerable challenge to clinicians due to its multidrug-resistant nature. Recent world events, such as the COVID-19 pandemic, have highlighted the need for effective treatment and management strategies for Acinetobacter pneumonia. In this review, we discuss lessons learned from recent world events, particularly the COVID-19 pandemic, in the context of the treatment and management of Acinetobacter pneumonia. We performed an extensive literature review to uncover studies and information pertinent to the topic. The COVID-19 pandemic underscored the importance of infection control measures in healthcare settings, including proper hand hygiene, isolation protocols, and personal protective equipment use, to prevent the spread of multidrug-resistant pathogens like Acinetobacter . Additionally, the pandemic highlighted the crucial role of antimicrobial stewardship programs in optimizing antibiotic use and curbing the emergence of resistance. Advances in diagnostic techniques, such as rapid molecular testing, have also proven valuable in identifying Acinetobacter infections promptly. Furthermore, due to the limited availability of antibiotics for treating infections caused A. baumannii , alternative strategies are needed like the use of antimicrobial peptides, bacteriophages and their enzymes, nanoparticles, photodynamic and chelate therapy. Recent world events, particularly the COVID-19 pandemic, have provided valuable insights into the treatment and management of Acinetobacter pneumonia. These lessons emphasize the significance of infection control, antimicrobial stewardship, and early diagnostics in combating this challenging infection.

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“…It’s vital to emphasize that these outcomes are primarily influenced by bacterial infections rather than viral ones. 244 …”

Section: Pneumonia and Covid-19mentioning

confidence: 99%

Treatment and Management of Acinetobacter Pneumonia: Lessons Learned from Recent World Event

Rangel,

De-Simone

2024

IDR

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“…Concurrent bacterial and fungal infections have played an important role in hospital outcomes during the COVID-19 pandemic [7]. Recently, Bassetti et al [8 ▪▪ ], provided a global overview of the prevalence of Staphylococcus aureus and methicillin-resistant S. aureus in this population.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Gram-negative bacteria during coronavirus disease 2019. What is the real pandemic?

Brink

Richards

Tootla

et al. 2022

Current Opinion in Infectious Diseases

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Purpose of reviewBacterial infections play a key role in hospital outcomes during the coronavirus disease 2019 (COVID-19) pandemic. Nonetheless, the global impact on the epidemiology of Gram-negative bacteria (GNB) and antibiotic resistance has not been clearly established.Recent findingsMultiple limitations exist in the current literature, in that substantial variability was observed with regard to methodology. Notwithstanding the heterogeneity, the evidence suggests that the COVID-19 pandemic had a substantial negative impact on global epidemiology with an increase in hospital-onset infections, associated with GNB. Similarly, an alarming increase in resistant GNB compared to prepandemic rates, was apparent. This was most evident for carbapenemase-producing Klebsiella pneumoniae (bloodstream infections), carbapenem-resistant Pseudomonas aeruginosa (ventilator-associated pneumonia), and carbapenem-resistant Acinetobacter baumannii (all infections). Significant variations were most apparent in the large, system-wide regional or national comparative assessments, vs. single-centre studies. Categorizing concurrent bacteria as co- or secondary-infections may be paramount to optimize standard of care.SummaryThe data from most studies signal the probability that COVID-19 accelerated resistance. However, multiple limitations intrinsic to interpretation of current COVID-19 data, prevents accurately quantifying collateral damage on the global epidemiology and antibiotic resistance amongst GNB. It is likely to be substantial and renewed efforts to limit further increases is warranted.

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“…Concurrent bacterial and fungal infections have played an important role in hospital outcomes during the COVID-19 pandemic [ 9 ]. Recently, Bassetti et al provided a global overview of the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) in this population and confirmed that MRSA was a common causative agent of pneumonia in patients with COVID-19 [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Stewardship: Leveraging the “Butterfly Effect” of Hand Hygiene

Brink

Richards

2022

Antibiotics

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It is vital that there are coordinated, collaborative efforts to address the threat of antimicrobial resistance (AMR) and to prevent and control the spread of hospital-onset infections, particularly those due to multidrug-resistant (MDR) pathogens. The butterfly effect is a concept in which metaphorically speaking, small, seemingly trivial events ultimately cascade into something of far greater consequence, more specifically by having a non-linear impact on very complex systems. In this regard, antimicrobial stewardship programs (ASP), when implemented alongside infection prevention control (IPC) interventions in hospitals, particularly hand hygiene (HH), are significantly more effective in reducing the development and spread of AMR bacteria than implementation of ASP alone. In this perspective, we briefly review the evidence for the combined effect, and call for closer collaboration between institutional IPC and ASP leadership, and for well-functioning IPC programs to ensure the effectiveness of ASP.

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Effect of Inadequate Empiric Antibacterial Therapy on Hospital Outcomes in SARS-CoV-2-Positive and -Negative US Patients With a Positive Bacterial Culture: A Multicenter Evaluation From March to November 2020

Cited by 18 publications

References 31 publications

Treatment and Management of Acinetobacter Pneumonia: Lessons Learned from Recent World Event

Treatment and Management of Acinetobacter Pneumonia: Lessons Learned from Recent World Event

Epidemiology of Gram-negative bacteria during coronavirus disease 2019. What is the real pandemic?

Antimicrobial Stewardship: Leveraging the “Butterfly Effect” of Hand Hygiene

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