This research explored the influences of entropy generation on bioconvected nanoliquid flow through the porous cavity filled with nanofluid and gyrotactic microbes. The porosity term in the momentum equation is summarized by the implementation of Darcy’s formula through Boussinesq estimation. The novelty of this study is to investigate entropy generation in cavity by augmenting the convection generated by the phenomenon of Brownian motion, thermophoresis of nanofluid flow and the bioconvection due to swimming of microorganisms. The governing partial differential equations (PDEs) are highly nonlinear and are nondimensionalized through the suitable similarity constraints. The transformed PDEs are tackled via implementation of finite difference method (FDM). The reaction of entropy generation and Bejan number against various quantities like bioconvection Rayleigh number ([Formula: see text]–100), Rayleigh number ([Formula: see text]–100), Peclet number ([Formula: see text]–0.9) and ratio of buoyancy ([Formula: see text]–1) are reported and visualized. The entropies by the liquid friction, heat transportation, mass transmission and microorganisms are focused. Upsurge in Nr (0.3–0.5) and Pe (0.1–0.15) accelerated the maximum of entropy due to microorganism by 7% and 44%, respectively. Here, an increment in Ra, Rb, Pe and Nr affects the distribution pattern of total entropies and Bejan number consistently. The higher Lewis number caused a decrement in the total entropy by liquid friction.