Effect of Inclusion Complexation with Cyclodextrin on the Cloud Point of Poly(2-(dimethylamino)ethyl methacrylate) Solution

Zhao, Yu; Guo, Kai; Wang, Chunyu; Wang, Liyan

doi:10.1021/la9047819

Cited by 23 publications

(23 citation statements)

References 31 publications

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“…The hydrophilic nature of β‐CD on the exterior might hinder the formation of hydrophobic microdomains through self‐association. It was reported that the CP of poly(2‐(dimethylamino)ethylmethacrylate) solution in the presence of randomly methylated β‐CD rose similarly as in the present study, and a nonlinear relationship was established between the CP and the ratios of randomly methylated β‐CD to the guest for the inclusion complexation equilibrium . In contrast, the use of α‐CD (Figure B), instead of β‐CD, shows a change of CP less than 1 °C, suggesting that the smaller cavity size of α‐CD is not suited for threading onto the CA units to form PPR, even though it could form complex with PEG .…”

Section: Methodssupporting

confidence: 71%

A Molecular Necklace: Threading β‐Cyclodextrins onto Polymers Derived from Bile Acids

et al. 2016

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A molecular necklace of polypseudorotaxanes was prepared by threading b-cyclodextrins (b-CD) onto biodegradable and thermoresponsive polyurethanes derived from bile acids. These polyurethanes were synthesized via a simple step condensation of bile acid-based dicarbonate with poly-(ethylene glycol)-diamine. The b-CD rings slide onto the poly(ethylene glycol) segments and selectively recognize the bile acid units of the polyurethane chains, whereas the poly(ethylene glycol) segments remain crystalline with a lower crystallinity. This bio-compound-derived molecular necklace can be visualized by scanning tunneling microscopy. The polypseudorotaxanes show thermosensitivity in water and the phase transition temperature may be fine-tuned by varying the molar ratios of b-CD to the bile acid units. Such an interesting necklace model of polypseudorotaxane constructed from natural compounds may lead to the further exploration of their applications, such as as an enzyme model, due to their biological nature.

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Section: Methodssupporting

confidence: 71%

A Molecular Necklace: Threading β‐Cyclodextrins onto Polymers Derived from Bile Acids

et al. 2016

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“…Firstly, the drug release rate was accelerated by the higher solubility of DOX in acidic solution than in neutral solution; secondly, DOX could be released more easily from the core due to the extension of the protonated PDMAEMA chains in the acidic condition. This is because PDMAEMA chains are pH-sensitive with a pK a of about 7.1 [33]. This result indicates that DOX could be readily released via endosomal- (pH 5.5–6) or lysosomal-pH (pH 4–5) in cells [34] and thus could induce antitumor activity.…”

Section: Resultsmentioning

confidence: 99%

A Polycationic Brush Mediated Co-Delivery of Doxorubicin and Gene for Combination Therapy

et al. 2019

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The combination of drug and gene strategies for cancer therapy, has exhibited greater effectiveness than drug or gene therapy alone. In this paper, a coil-comb shaped polycationic brush was used as a multifunctional carrier for co-delivery of drug and gene. The side chains of the comb block of the brush were composed of cyclodextrin (CD)-containing cationic star polymers, with a super-high density of positive charge. Doxorubicin (DOX) could be loaded into the cavity of CD polymers to form DOX-loaded nanoparticles (DOX-NPs) and the p53 gene could be subsequently condensed by DOX-NPs. The obtained DOX-NPs/pDNA complexes were less than 150 nm in size, and so could transport DOX and the gene into the same cell. The complexes performed well with regards to their transfection efficiency on MCF-7 cancer cells. As a result, enhanced cell growth inhibition, with decreased DOX dosage was achieved due to the synergistic effect of co-delivery of DOX and the p53 gene. This finding provides an efficient approach for the development of a co-delivery system in combination therapy.

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“…2) as mentioned above. Chemical shift assignments were taken from the literature [24,25]. The NMR spectrum of PMMA 50 -b-PDMAEMA 269 (X) Table 2.…”

Section: Resultsmentioning

confidence: 99%

Characterization of PMMA-b-PDMAEMA aggregates in aqueous solutions

et al. 2019

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Diblock amphiphilic copolymers form aggregates in some solvents. Such aggregates exhibit different morphologies, depending mainly on the polar/apolar block ratios. Aggregation of copolymers with polar block excess leads to micelle-like aggregates, known as polymeric micelles, which can be used as vehicles for drug and gene delivery, water decontamination, and catalysis. Here, we synthesized by RAFT polymerization three different polymers namely [dimethyl 2-(aminoethyl) methacrylate] (PDMAEMA), poly (methyl methacrylate) (PMMA) copolymers, and PDMAEMA-block-PMMA and characterized their aggregates by NMR spectroscopy and pH titrations. We investigated correlations between their chemical structure, aggregation behavior, protonation degree, and chain conformation in the corona. Decreased amine protonation in the copolymers reduced the electrostatic repulsion, and the apparent pK a of the amino groups approached that of isolated amine. These effects increased compactness and sizes of the polymers and their aggregates at higher pH as reflected by the increased NMR line widths.

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Effect of Inclusion Complexation with Cyclodextrin on the Cloud Point of Poly(2-(dimethylamino)ethyl methacrylate) Solution

Cited by 23 publications

References 31 publications

A Molecular Necklace: Threading β‐Cyclodextrins onto Polymers Derived from Bile Acids

A Molecular Necklace: Threading β‐Cyclodextrins onto Polymers Derived from Bile Acids

A Polycationic Brush Mediated Co-Delivery of Doxorubicin and Gene for Combination Therapy

Characterization of PMMA-b-PDMAEMA aggregates in aqueous solutions

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