Effect of Indigestible Saccharides on B Lymphocyte Response of Intestinal Mucosa and Cecal Fermentation in Rats.

Kudoh, Keita; Shimizu, Jun; Wada, Masahiro; Takita, Toshichika; Kanke, Yusuke; Innami, Satoshi

doi:10.3177/jnsv.44.103

Cited by 46 publications

(30 citation statements)

References 24 publications

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“…Lim et al 5) reported that pectin significantly increased the ratio of CD4 + /CD8 + in rat lymphocytes from the mesenteric lymph nodes. Kudoh et al 6) reported that the ratio of CD3 + cells in splenocytes was significantly decreased in rats fed gum arabic, as compared with cellulose powder. In addition, the oral administration of easily fermented oligosaccharides such as short-chain fructooligosaccharide and oligofructose affects T cell status and tumor induction.…”

Section: Discussionmentioning

confidence: 99%

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Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

Shimizu

Wada-Funada

Miyata

et al. 2005

JOURNAL OF HEALTH SCIENCE

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Male BALB/c mice were administered three fucoidans with different molecular weights prepared from Okinawa mozuku (Cladosiphon okamuranus). The proportion of CD8 + cells in the spleens of mice fed with high molecular-weight fucoidan significantly increased compared with those in mice fed a control diet. In addition, the CD4 + /CD8 + ratio tended to decrease and the proportion of CD11b + cells to increase. These results suggest that high molecular-weight fucoidan promotes an increase in the proportion of murine cytotoxic T cells.

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Section: Discussionmentioning

confidence: 99%

“…5,6) CD4 or CD8 on the mature T cell surface plays an important role in the stimulation of T cells as coreceptors in antigen recognition of the T cell receptor/CD3 complex.…”

Section: Introductionmentioning

confidence: 99%

Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

Shimizu

Wada-Funada

Miyata

et al. 2005

JOURNAL OF HEALTH SCIENCE

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“…It is possible that the effects are secondary to SCFA production since certain fermentable dietary fibers have been reported to increase the total number of IgApresenting lymphocytes in small intestinal and cecal mucosa. 39) There is growing evidence that ingestion of fermentable fiber increases colonic mucin secretion, presumably through SCFA production in the large bowel. 40) Barcelo et al 7) reported that SCFA stimulated mucin secretion by the isolated rat colon, suggesting that HAS can act via this mechanism.…”

Section: Discussionmentioning

confidence: 99%

Dietary Resistant Starch Alters the Characteristics of Colonic Mucosa and Exerts a Protective Effect on Trinitrobenzene Sulfonic Acid-induced Colitis in Rats

Morita¹,

Tanabe²,

Sugiyama³

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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The protective effect of a dietary high-amylose cornstarch (HAS) against trinitrobenzene sulfonic acid (TNBS)-induced colitis was examined in rats. Rats were fed a HAS-free basal diet or, a 15% or 30% HAS supplemented diet for 10 d, and then received intracolonic TNBS to induce colitis and fed the respective diets for a further 8 d. HAS ingestion significantly protected colonic injuries as evidenced by lower colonic myeloperoxidase activity. Rats fed the HAS diet showed greater cecal short-chain fatty acid (SCFA) production than those fed the basal diet. Further, just before TNBS administration, HAS ingestion dose-dependently increased fecal and cecal mucin contents, and protein and nucleic acid contents in the colonic mucosa. HAS ingestion also reduced colonic permeability. The protective effect of HAS ingestion on TNBS-induced colitis is perhaps exerted through alterations in colonic mucosa, possibly due to cecal SCFA production.Key words: high-amylose cornstarch; trinitrobenzene sulfonic acid; short-chain fatty acids; mucin; ratsThe etiology of inflammatory bowel disease, encompassing Crohn's disease and ulcerative colitis, remains unknown, but studies in animal models suggest that disruption of mucosal barrier function may induce abnormal immune responses to luminal bacteria, resulting in acute and chronic inflammation in the large bowel.1) Mucosal barrier function has been ascribed to colonic epithelial cells based on mucus production and shedding of surface cells, which are replenished by renewal from crypt cells.2) In this regard, short-chain fatty acids (SCFA: mainly acetate, propionate, and butyrate), products of large bowel fermentation by bacteria, have been reported to be major fuels for colonic epithelial cells and to accelerate epithelial cell proliferation. 3,4) Earlier studies indicated that SCFA irrigation stimulated the mucosal repair process and decreased inflammation in human patients 5) and rats injected with trinitrobenzene sulfonic acid 6) (TNBS). Also, Barcelo et al. 7) found that a physiological concentration of butyrate and acetate caused a significant increase in mucus secretion in the lumen of isolated perfused rat colon. Greater mucin production might contribute to the lower incidence of bacterial translocation across the gut barrier reported in studies that fed dietary fiber. 8) Clearly, SCFAs are considered to be of benefit in the treatment of inflammatory bowel disease.Although SCFA delivery to the colon might be accomplished with an enteric-coated capsule or a rectal infusion of SCFA, the nutritional approach is more physiological, consistent, and cost-effective, and less stressful. One potential route is to increase the consumption of foods high in resistant starch, because studies in experimental animals have shown that the feeding of resistant starch, such as high-amylose cornstarch (HAS), increases the large bowel digesta SCFA level in rats [9][10][11] and pigs. 12) Previously we found that ingestion of HAS prevented endotoxin influx from the intestinal tract into the portal ...

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“…respectively Short-chain fatty acids (SCFAs). One gram of the cecal contents was suspended in 1ml of methanol and extracted SCFAs were analyzed by gas chromatography by the method of Kudoh et al (11).…”

Section: Methodsmentioning

confidence: 99%

Plasma Cholesterol Reduction by Defatted Soy Ontjom (Fermented with Neurospora intermedia) in Rats Fed a Cholesterol-free Diet.

Matsuo

2000

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryTo popularize defatted soy ontjom (DSB-ontjom, soy product fermented with Neurospora intermedia) as a new food, I examined the plasma cholesterol-reducing effects of DSB-ontjom and DSB in rats fed cholesterol-free diets and compared the efficiencies of these effects. DSB-ontjom greatly reduced the plasma cholesterol level and increased fecal steroid excretion as compared to DSB. DSB-ontjom was rich in pepsin-resistant protein having a high bile acid binding capacity and was abundant in isoflavone-aglycones, especially daizein. The dietary fiber (DF) of DSB-ontjom stimulated the production of short-chain fatty acids (SCFAs) by intestinal microflora. The effect of DSB-ontjom on plasma cholesterol re duction was attributed to the collaborative effects of pepsin-resistant-protein, isoflavone aglycones and SCFA-producing DF in DSB-ontjom.

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Effect of Indigestible Saccharides on B Lymphocyte Response of Intestinal Mucosa and Cecal Fermentation in Rats.

Cited by 46 publications

References 24 publications

Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

Dietary Resistant Starch Alters the Characteristics of Colonic Mucosa and Exerts a Protective Effect on Trinitrobenzene Sulfonic Acid-induced Colitis in Rats

Plasma Cholesterol Reduction by Defatted Soy Ontjom (Fermented with Neurospora intermedia) in Rats Fed a Cholesterol-free Diet.

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