Effect of indomethacin in preventing surgically induced miosis.

Vos, H C Keulen-de; Rij, Gabriël van; J, Lavalette; Jansen, Jan

doi:10.1136/bjo.67.2.94

Cited by 46 publications

(16 citation statements)

References 15 publications

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“…This is in accordance with previous studies. 10,11,16,17,20,31 A previous report indicated that the pupils of diabetics who had previous laser treatment dilate less compared to those who did not require laser. 10 In our study, only eight of the 76 patients had required laser treatment prior to cataract surgery (five had laser for maculopathy and three for proliferative retinopathy).…”

Section: Discussionmentioning

confidence: 99%

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Surgically induced miosis during phacoemulsification in patients with diabetes mellitus

Mirza

Αλεξανδρίδου

Marshall

et al. 2003

Eye

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Purpose To assess the incidence of surgically induced miosis during phacoemulsification in diabetic patients. Methods A total of 76 patients with diabetes mellitus were compared to 76 age-and race-matched controls. A combination of cyclopentolate 1%, phenylephrine 2.5% and diclofenac sodium 0.1% was applied topically 60, 45 and 30 min before surgery. Adrenaline mixed with buffered saline solution was used for irrigation during surgery. The procedure included phacoemulsification and implantation into the bag of a foldable acrylic implant. Measurements of the horizontal pupillary diameter were taken at three stages: before corneal incision, after phacoemulsification, and at the end of surgery.

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Section: Discussionmentioning

confidence: 99%

“…[14][15][16][17] The use of adrenaline in the irrigating solution during cataract surgery has also been shown to maintain mydriasis. 18,19 In our study, intraoperative miosis occurred more often in the diabetics.…”

Section: Discussionmentioning

confidence: 99%

Surgically induced miosis during phacoemulsification in patients with diabetes mellitus

Mirza

Αλεξανδρίδου

Marshall

et al. 2003

Eye

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“…The clinical use of nonsteroidal antiinflammatory drugs (NSAIDs) in reducing the amount of surgically induced miosis (SIM) during ECCE and PCIOL implantation has been previously reported [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The efficacy of Indomethacin and more recently of Flurbiprofen in the maintenance of mydriasis during ECCE is well documented [1,2,4,6,12,13]. Diclofenac is however a new drug with a limited clinical reports [5].…”

Section: Introductionmentioning

confidence: 99%

The effect of Indomethacin, Diclofenac and Flurbiprofen on the maintenance of mydriasis during extracapsular cataract extraction

et al. 1992

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Surgically induced miosis (SIM) frequently occurs during extracapsular cataract extraction (ECCE). A randomized clinical trial was performed to evaluate the effect of 3 nonsteroidal antiinflammatory drugs Indomethacin 1%, Diclofenac 0.1% and Flurbiprofen 0.03%, administered topically before ECCE, on the maintenance of mydriasis during surgery. The patients were grouped based on the type of NSAID given preoperatively in addition to the standard mydriatic agents: 46 patients in group A (Indomethacin), 40 patients in B (Diclofenac), 44 patients in C (Flurbiprofen) and 34 patients formed control group D (no NSAID was instilled). Horizontal pupillary diameter measurements were taken, using a caliper, immediately prior to surgery (step 0), after capsulotomy (step I), after expression of the lens nucleus (step II) and after irrigation-aspiration of the cortical remnants (step III). Differences in pupillary diameter between step 0 and the different surgical steps were used as indices of pupillary constrictions observed in the 4 groups. A significantly less pupillary constriction was found in groups A and C than in D between steps 0 and II (p = 0.01) and in groups A and C than in B and D between steps 0 and III (p = 0.001). Our results show that Indomethacin 1% and Flurbiprofen 0.03%, compared to Diclofenac 0.1% and no NSAID regime, are significantly more effective in maintaining mydriasis during cataract surgery.

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“…So far, classical autonomic drugs are the only way to manipulate pupil diameter clinically. Atropine-resistant miosis, observed in patients with pseudoexfoliation syndrome or following irritation of the iris, is an important factor in successful intraocular surgery [1,2]. It is thought that various biological substances released after chemical or mechanical stimulation of the eye are responsible for this miosis [3,4].…”

Section: Introductionmentioning

confidence: 99%

Gene Transfer by Adenovirus in Rabbit Iris Sphincter Muscle

2001

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The effect of insertion of an exogenous gene on smooth muscle function in rabbit iris sphincter muscle was investigated. An adenoviral vector encoding the bacterial LacZ gene (AdLacZ, 10⁷ pfu) and viscoelastics were injected into the posterior chamber of eyes of albino rabbits. Three days after injection, the effects of acetylcholine (Ach), carbachol (Carb), substance P (SP) and electrical field stimuli on isolated iris sphincter were investigated using isometric tension-recording methods. X-Gal histostaining showed that iris sphincter smooth muscle cells were transfected in 7 of 11 muscle strips. Contraction-response curves for Ach, Carb or SP were not different from control. We conclude that the iris sphincter muscle can be gene-transfected by posterior chamber infusion of an adenoviral vector with viscoelastics. Adenovirus-mediated gene transfer per se had no measurable effect on tension development.

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Effect of indomethacin in preventing surgically induced miosis.

Cited by 46 publications

References 15 publications

Surgically induced miosis during phacoemulsification in patients with diabetes mellitus

Surgically induced miosis during phacoemulsification in patients with diabetes mellitus

The effect of Indomethacin, Diclofenac and Flurbiprofen on the maintenance of mydriasis during extracapsular cataract extraction

Gene Transfer by Adenovirus in Rabbit Iris Sphincter Muscle

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