Effect of induced high myopia on functional MRI signal changes

Mirzajani, Ali; Ghorbani, Mohammad; Rasuli, Behrouz; Mahmoud-Pashazadeh, Ali

doi:10.1016/j.ejmp.2017.04.004

Cited by 9 publications

(11 citation statements)

References 24 publications

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“…Accommodation at birth is limited to objects located within a range of 40-50 cm (Horwood and Riddell, 2008), with a possibly parallel ongoing attentional limitation (Downey et al, 2017). At the neural level, accommodation is associated with brain activity in the visual cortex (Mirzajani et al, 2017) and relies on an extended cortico-cerebellar network, including links of the visual cortex with cerebellar hemispheres/vermis and temporal cortex (Richter et al, 2000), as well as with precentral and frontal regions (Lv et al, 2020).…”

Section: Accommodationmentioning

confidence: 99%

Visual Neuropsychology in Development: Anatomo-Functional Brain Mechanisms of Action/Perception Binding in Health and Disease

Ionta

2021

Front. Hum. Neurosci.

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Vision is the main entrance for environmental input to the human brain. Even if vision is our most used sensory modality, its importance is not limited to environmental exploration. Rather it has strong links to motor competences, further extending to cognitive and social aspects of human life. These multifaceted relationships are particularly important in developmental age and become dramatically evident in presence of complex deficits originating from visual aberrancies. The present review summarizes the available neuropsychological evidence on the development of visual competences, with a particular focus on the associated visuo-motor integration skills in health and disease. With the aim of supporting future research and interventional settings, the goal of the present review is to constitute a solid base to help the translation of neuropsychological hypotheses into straightforward empirical investigations and rehabilitation/training protocols. This approach will further increase the impact, ameliorate the acceptance, and ease the use and implementation of lab-derived intervention protocols in real-life situations.

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Section: Accommodationmentioning

confidence: 99%

Visual Neuropsychology in Development: Anatomo-Functional Brain Mechanisms of Action/Perception Binding in Health and Disease

Ionta

2021

Front. Hum. Neurosci.

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“…Noppeney et al [50] discovered that early blind individuals had decreased gray matter (GM) and white matter (WM) volumes in the visual system and increased WM volumes in the sensory-motor system. Mirzajani et al [51] reported that severe blurring caused by lens-induced HM could cause a BOLD signal intensity decrease in the visual cortex. Guo et al [52] observed that HM subjects showed a decreased amplitude of low-frequency fluctuation (ALFF) in the bilateral frontal lobe, right parietal lobe, and right middle temporal lobe in the eyes-closed condition compared to that in the emmetropia group.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study

Chen

Wang

et al. 2020

Neural Plasticity

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Objective. The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods. A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls (HCs) were recruited. All subjects were right-handed. Image data preprocessing was performed using SPM8 and the DPABI toolbox. Clinical parameters were acquired in the HM group. Two-sample t-tests and Pearson correlation analysis were applied in this study. Results. Compared to HCs, patients with HM exhibited significantly increased CBF in the bilateral cerebellum, and no decreases in CBF were detected in the brain. However, no relationship was found between the mean CBF values in the different brain areas and the disease duration (P>0.05). Conclusions. Using ASL analysis, we detected aberrant blood perfusion in the cerebellum in HM patients, contributing to a better understanding of brain abnormalities and brain plasticity through a different perspective.

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“…Therefore, it would seem that vitreous elongation and the consequent myopia may develop not only due to optical degradation of the image formed on the retina, but also due to loss of afferent cone input to higher visual centers. Indeed, it has been shown that myopia is associated with anatomical changes in the visual cortex, including reduced functional connectivity density in visual centers 68,69 , smaller gray matter volume 70 and reduced intracranial volume 71 . Similar cortical reorganization has been reported in humans with congenital rod monochromacy (cone absence) 72 .…”

Section: Discussionmentioning

confidence: 99%

Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia

Ross

Ofri

Aizenberg

et al. 2020

Sci Rep

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Achromatopsia is an inherited retinal disease characterized by loss of cone photoreceptor function. Day blind CNGA3 mutant Improved Awassi sheep provide a large animal model for achromatopsia. This study measured refractive error and axial length parameters of the eye in this model and evaluated chromatic pupillary light reflex (cPLR) testing as a potential screening test for loss of cone function. Twenty-one CNGA3 mutant, Improved Awassi, 12 control Afec-Assaf and 12 control breed-matched wild-type (WT) Awassi sheep were examined using streak retinoscopy and B-mode ocular ultrasonography. Four CNGA3 mutant and four Afec-Assaf control sheep underwent cPLR testing. Statistical tests showed that day-blind sheep are significantly more myopic than both Afec-Assaf and WT Awassi controls. Day-blind sheep had significantly longer vitreous axial length compared to WT Awassi (1.43 ± 0.13 and 1.23 ± 0.06 cm, respectively, p < 0.0002) and no response to bright red light compared to both controls. Lack of response to bright red light is consistent with cone dysfunction, demonstrating that cPLR can be used to diagnose day blindness in sheep. Day-blind sheep were found to exhibit myopia and increased vitreous chamber depth, providing a naturally occurring large animal model of myopia.

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Effect of induced high myopia on functional MRI signal changes

Cited by 9 publications

References 24 publications

Visual Neuropsychology in Development: Anatomo-Functional Brain Mechanisms of Action/Perception Binding in Health and Disease

Visual Neuropsychology in Development: Anatomo-Functional Brain Mechanisms of Action/Perception Binding in Health and Disease

Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study

Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia

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