“…As atherosclerosis can affect arteries beyond the point at which they can be grafted, there is a theoretical argument to be made for a drug which dilates the smaller vessels. Nitroglycerin increases blood flow in the coronary arteries beyond the points of narrowing (Fam and McGregor, 1964;Fam et al, 1966) and it also dilates collaterals; the myocardial oxygen tension in the areas of distribution of the occluded vessels will thus be increased. Many components of the response to nitroglycerin, namely decrease in cardiac size (Bousvaros, Campbell, and McGregor, 1966) decrease in venous return (Gorlin et al, 1959) decrease in pulmonary and systemic arterial pressure and rate of ventricular contraction (Darby and Aldinger, 1960) will decrease the myocardial oxygen consumption (Robin et al, 1967).…”