Effect of Infant and Follow‐on Formulas Containing <i>B lactis</i> and Galacto‐ and Fructo‐oligosaccharides on Infection in Healthy Term Infants

Bocquet, A.; Lachambre, E.; Kempf, Christian; Beck, L.

doi:10.1097/mpg.0b013e318297f35e

Cited by 21 publications

(21 citation statements)

References 32 publications

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“…19 Formulas containing Bifido lactis and a GOS/FOS prebiotic mixture did not reduce infection rates beyond those containing only Bifido lactis. 52 In conclusion: only limited data suggest that prebiotic oligosaccharides improve general health and reduce infections.…”

Section: Prebiotics and Stool Consistencymentioning

confidence: 99%

Prebiotics in infant formula

2014

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The gastrointestinal microbiota of breast-fed babies differ from classic standard formula fed infants. While mother's milk is rich in prebiotic oligosaccharides and contains small amounts of probiotics, standard infant formula doesn't. Different prebiotic oligosaccharides are added to infant formula: galacto-oligosaccharides, fructo-oligosaccharide, polydextrose, and mixtures of these. There is evidence that addition of prebiotics in infant formula alters the gastrointestinal (GI) microbiota resembling that of breastfed infants. They are added to infant formula because of their presence in breast milk. Infants on these supplemented formula have a lower stool pH, a better stool consistency and frequency and a higher concentration of bifidobacteria in their intestine compared to infants on a non-supplemented standard formula. Since most studies suggest a trend for beneficial clinical effects, and since these ingredients are very safe, prebiotics bring infant formula one step closer to breastmilk, the golden standard. However, despite the fact that adverse events are rare, the evidence on prebiotics of a significant health benefit throughout the alteration of the gut microbiota is limited.

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Section: Prebiotics and Stool Consistencymentioning

confidence: 99%

Prebiotics in infant formula

2014

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“…Mean daily weight gain was slightly lower in the B.lactis + GOS/FOS than the B lactis group (16.1 ± 2.9 vs 16.6 ± 2.6 g/day, p = 0.046), but was not clinically significant. 42 Other outcomes were not significantly different between groups. Formulas containing B.lactis + GOS/FOS did not reduce infection rates beyond those containing only B lactis.…”

Section: Synbioticsmentioning

confidence: 84%

“…Formulas containing B.lactis + GOS/FOS did not reduce infection rates beyond those containing only B lactis. 42 Chang et al 43 conclude in their metaanalysis that evidence supports the use of synbiotics for the treatment of atopic dermatitis, particularly synbiotics with mixed strains of bacteria and for children aged 1 year or older. Nevertheless, infant formula companies promote the combination of pre-and probiotics in infant formula.…”

Section: Synbioticsmentioning

confidence: 99%

Probiotic interventions to optimize the infant and child microbiota

Vandenplas

Huysentruyt

2018

World Nutr J

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The optimal healthy microbiota during early life still needs further evaluation. Pre- and probiotics are commonly used as supplementation in infant formula.Prebiotic oligosaccharides stimulate the growth of bifidobacteria aiming to mimic the gastrointestinal microbiota of breastfed infants. In general, results with prebiotics in therapeutic indications are disappointing.Studies suggest that probiotic supplementation may be beneficial in prevention and management of disease such as e.g., reducing the risk of necrotizing enterocolitis in preterm infants, prevention and treatment of acute gastroenteritis in infants, etc. Although many studies show promising beneficial effects, the long-term health benefits and eventual risks of probiotic supplementation during early life are not clear.It is likely that ongoing research will result in the use of specific probiotic organisms and/or prebiotic oligosaccharides during the first 1,000 days of life, with the goal to develop a healthy microbiota from conception over birth into the first two years of life with a lowered risk of infections and inflammatory events.

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“…With increasing age, infants produced fewer stools of greater firmness [ 13 ]. Infant and follow-on formulas containing B. lactis and galacto-oligoaccharides (GOS) and FOS were reported to be safe, without any additional benefit of the prebiotic over the probiotic [ 14 ]. A meta-analysis of seven different trials with infant formula supplemented with B. lactis results in growth similar to what is found in infants fed unsupplemented formula [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Safety of a New Synbiotic Starter Formula

Vandenplas

Analitis

Tziouvara

et al. 2017

Pediatr Gastroenterol Hepatol Nutr

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PurposeBreastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding.MethodsThe safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months.ResultsThe median age of the infants at inclusion was 0.89 months. Weight evolution was in accordance with the World Health Organization growth charts for exclusive breastfed infants. The evolution of all anthropometric parameters (weight-for-length z score and body mass index-for-age z score) was within the normal range. The incidence of functional constipation (3.2%), daily regurgitation (10.9%), infantile crying and colic (10.5%) were all significantly lower than the reported median prevalence for a similar age according to literature (median value of 7.8% for functional constipation, 26.7% for regurgitation, 17.7% for infantile colic).ConclusionThe new synbiotic infant starter formula was safe, resulted in normal growth and was well tolerated. Functional gastro-intestinal manifestations (functional constipation, regurgitation and colic) were significantly lower than reported in literature. Synbiotics (Bifidobacterium lactis and fructo-oligosaccharides) in cow's milk based infant formula bring the second choice infant feeding, formula, closer to the golden standard, exclusive breastfeeding.

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Effect of Infant and Follow‐on Formulas Containing B lactis and Galacto‐ and Fructo‐oligosaccharides on Infection in Healthy Term Infants

Abstract: Formulas containing B lactis + GOS/FOS did not reduce infection rates beyond those containing only B lactis.

Cited by 21 publications

References 32 publications

Prebiotics in infant formula

Prebiotics in infant formula

Probiotic interventions to optimize the infant and child microbiota

Safety of a New Synbiotic Starter Formula

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