Effect of influenza immunization on CYP3A4 activity

Hayney, Mary S.; Hammes, Richard J.; Fine, Jason P.; Bianco, Jesus A.

doi:10.1016/s0264-410x(01)00403-0

Cited by 13 publications

(18 citation statements)

References 26 publications

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“…The dilution of serum that no longer inhibits hemagglutination was the influenza antibody titer. [17–19] A protective antibody response to influenza vaccine was defined as an antibody titer equal to or greater than 1:40. Seroconversion following influenza immunization was defined as a fourfold increase in antibody concentrations.…”

Section: Methodsmentioning

confidence: 99%

Decreased Immune Responses to Influenza Vaccination in Patients With Heart Failure

Vardeny

Sweitzer

Detry

et al. 2009

Journal of Cardiac Failure

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Section: Methodsmentioning

confidence: 99%

Decreased Immune Responses to Influenza Vaccination in Patients With Heart Failure

Vardeny

Sweitzer

Detry

et al. 2009

Journal of Cardiac Failure

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“…The effect was shown to be largest in individuals with high theophylline clearance before vaccination (Meredith et al, 1985), probably those with high CYP1A2 activity. On the other hand, influenza immunization did not significantly change CYP3A4 or CYP2E1 activities, as measured by the erythromycin breath test (ERMBT) and chlorzoxazone clearance (Kim and Wilkinson, 1996; Hayney et al, 2001). However, an inverse correlation between interferon-γ (IFN-γ) production and changes in ERMBT has been reported after administration of influenza vaccine to healthy volunteers (Hayney and Muller, 2003).…”

Section: Immunological Response and Cyp Metabolismmentioning

confidence: 99%

Immunological Response as a Source to Variability in Drug Metabolism and Transport

Christensen¹,

Hermann²

2012

Front. Pharmacol.

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Through the last decades it has become increasingly evident that disease-states involving cytokines affect the pharmacokinetics of drugs through regulation of expression and activity of drug metabolizing enzymes, and more recently also drug transporters. The clinical implication is however difficult to predict, since these effects are dependent on the degree of inflammation and may be changed when the diseases are treated. This article will give an overview of the present understanding of the effects of cytokines on cytochrome P450 enzymes and drug transporters, and highlight the importance of considering these issues in regard to increasing use of the relatively new class of drugs, namely therapeutic proteins.

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“…Kramer and McClain (1981) documented that the capacity of the mixed-function oxidase system following influenza vaccination decreased, while Kim and Wilkinson (1996) established that CYP2E1 activity in humans was not altered by influenza vaccination. Hayney et al (2001) proved that influenza immunisation did not significantly change CYP3A4 activity in humans, although they hypothesised that CYP3A4 activity would decrease following influenza immunisation because of a number of clinical reports of drug interaction with influenza vaccine. The interactions are assumed to be due to changes in the activity of cytochrome P450 enzymes (Grabenstein, 1990).…”

Section: Discussionmentioning

confidence: 99%

Effects of two infectious bursal disease vaccine virus strains on hepatic microsomal enzyme activities in chickens

Crnić¹,

Sakar²,

Pompe-Gotal³

et al. 2006

Acta Veterinaria Hungarica

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The influence of two infectious bursal disease vaccines on the activities of hepatic microsomal enzymes aniline hydroxylase, ethylmorphine N-demethylase, NADPH-cytochrome c reductase, aryl sulphotransferase and p-nitrophenol UDPglucuronyltransferase was investigated in chickens. The vaccines contained attenuated Winterfield 2512 and VMG-91 strains, respectively. The activities of enzymes were determined on postvaccination days 0, 2, 5 and 7. At the same time, post-mitochondrial supernatant, cytosolic and microsomal pellet protein concentrations were determined. As expected. the antibody titres against infectious bursal disease virus in the serum were increased in both tested groups in relation to each administered vaccine. Using RT-PCR, the presence of the VP2 gene fragment of virus in the liver of chicken was demonstrated 4 and 6 h after vaccination. The results of this study suggest that the two commercial vaccines modulate the activities of five enzymes tested, and that the two attenuated vaccines applied triggered induction and/or inhibition of phases I and II of biotransformation enzyme activities.

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Effect of influenza immunization on CYP3A4 activity

Cited by 13 publications

References 26 publications

Decreased Immune Responses to Influenza Vaccination in Patients With Heart Failure

Decreased Immune Responses to Influenza Vaccination in Patients With Heart Failure

Immunological Response as a Source to Variability in Drug Metabolism and Transport

Effects of two infectious bursal disease vaccine virus strains on hepatic microsomal enzyme activities in chickens

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