Effect of Inhaled Corticosteroids on Glycemic Status

Egbuonu, Francis; Antonio, Farrah A; Edavalath, Mahamood

doi:10.2174/1874306401408010101

Cited by 30 publications

(24 citation statements)

References 46 publications

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“…However, we cannot reject that there may exist a causal pathway between asthma and development of type 1 diabetes, perhaps mediated via inhaled corticosteroid therapy. 29 In parallel with our findings, other studies have not been able to detect differences in asthma risk after previous type 1 diabetes diagnosis. 12 Some have, however, shown an increased subsequent risk of asthma, 4,6 which could result from surveillance bias.…”

Section: Discussionsupporting

confidence: 90%

Familial Coaggregation of Asthma and Type 1 Diabetes in Children

et al. 2020

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IMPORTANCE The association between atopic and autoimmune disease, particularly asthma and type 1 diabetes, has been debated. Further understanding of the underlying factors associated with the comorbidity in children is warranted. OBJECTIVES To assess the bidirectional association between asthma and type 1 diabetes and examine the possibility of a shared risk for the diseases by studying their pattern of familial coaggregation.

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Section: Discussionsupporting

confidence: 90%

Familial Coaggregation of Asthma and Type 1 Diabetes in Children

et al. 2020

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“…Yucel et al found no effect of dose of inhaled corticosteroid and HbA1c value likewise in the current study there were no signi cant effects of dose of inhaled uticasone use on fasting plasma glucose, 2hour plasma glucose after 75 gm oral glucose and HbA1c% in the study group [8]. Some studies found dose dependent alteration of plasma glucose level although the subjects were diabetic [5,11,21].…”

Section: Discussionsupporting

confidence: 42%

“…Use of ICS in asthma for prolonged period and or higher dose has worsening effects on glycaemic status [7,8,9,10]. Several studies were done on the adverse effects of ICS revealing inconsistent ndings on glycaemic status of ICS users [11]. Therefore, this study was conducted on asthma patients to observe the glycaemic effect of inhaled uticasone users in Dhaka, Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

Plasma Glucose Levels of Asthma Patients Using Inhaled Fluticasone

Rahman

Hasan

Rahim

et al. 2020

Preprint

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Objective: Inhaled fluticasone is used in asthma for a long duration. However, It’s an adverse effect on glycaemia is debatable. This study explored the effect of inhaled fluticasone in long term asthma patients. A comparative cross-sectional study was conducted among the adult normoglycaemic asthma patients in Bangladesh between June 2017 to May 2018. The study groups were getting inhaled fluticasone for a minimum of three months whereas comparative group were not on any steroids. Each group had 35 eligible participants. Results: In study group, mean plasma glucose at fasting was 5.27 ± 0.48 mmol/L, 2-hour after 75gm oral glucose was 6.04 ± 1.21 mmol/L and mean of HbA1c was 5.57 ± 0.41 % whereas in comparative group these were 5.17 ± 0.59 mmol/L, 5.69 ± 1.09 mmol/L, 5.47 ± 0.40 % respectively (p= 0.25, 0.20, 0.75 respectively). Duration of inhaled fluticasone use had no specific co-relation with fasting plasma glucose, plasma glucose 2-hour after 75gm oral glucose and HbA1c% (r= 0.016, p= 0.46; r= 0.015, p= 0.47; r= 0.019, p= 0.42 respectively).

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“…Oral steroids could therefore have a significant impact upon the T2DM risk in asthma patients. There are mixed data relating to the effect of inhaled corticosteroids, which are prescribed for the vast majority of patients with asthma on diabetes incidence, although they may worsen glycaemic control in those with established diabetes [33]. Inhaled corticosteroid prescription was not assessed in any of the included studies.…”

Section: Confounding Factorsmentioning

confidence: 99%

Type 2 Diabetes and Asthma: Systematic Review of the Bidirectional Relationship

Rayner

McGovern

Creagh‐Brown

et al. 2019

CDR

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Background and objective Obesity is an important contributor to the risk of both asthma and type 2 diabetes (T2DM). However, it has been suggested that T2DM and asthma are also independently associated. The aim of this systematic review was to synthesise the evidence for an independent relationship between T2DM and asthma. Methods MEDLINE and EMBASE were searched for studies reporting the relationship between asthma and T2DM in adults. Given a potential bidirectional relationship, articles relating to T2DM as a risk factor for asthma, and asthma as a risk factor for T2DM were examined separately. Results Eight studies were identified for inclusion in the review (n=2,934,399 participants). Four studies examined incident diabetes in those with asthma. The pooled (random effects model) adjusted hazard ratio for incident T2DM in asthma was 1.37 (95%CI 1.12-1.69; p <0.001) after controlling for BMI. Four studies reported prevalence or incidence rates of asthma in people with T2DM; higher rates of asthma in those with T2DM were reported in all four studies. Meta-analysis of results was not possible due to methodological heterogeneity. The quality of included studies was good, but due to small numbers, publication bias cannot be excluded. Conclusions The published literature suggests a bidirectional independent relationship between T2DM and asthma, although we cannot exclude publication bias.

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Effect of Inhaled Corticosteroids on Glycemic Status

Cited by 30 publications

References 46 publications

Familial Coaggregation of Asthma and Type 1 Diabetes in Children

Familial Coaggregation of Asthma and Type 1 Diabetes in Children

Plasma Glucose Levels of Asthma Patients Using Inhaled Fluticasone

Type 2 Diabetes and Asthma: Systematic Review of the Bidirectional Relationship

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