Effect of injury on shivering thermogenesis in the rat

Stoner, H. B.

doi:10.1113/jphysiol.1971.sp009451

Cited by 30 publications

(20 citation statements)

References 23 publications

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“…increase in T, (Fig. 2) during the reduction of Ta from 30 to 50 C was 0-92 + 0.180 C (n = 13) which was significantly less (P < 0.01) than the corresponding value of 1-81 + 0.170 C (n = 9) in 20°C acclimated rats studied earlier (Stoner, 1971 Fig. 2.…”

Section: Resultsmentioning

confidence: 96%

“…When Ta fell below this zone non-shivering thermogenesis increased progressively and 666 NON-SHI VERING THERMOGENESIS in the 30 C acclimated rat was continuously variable over the Ta range studied. Unlike shivering (Stoner, 1971) there was no gap between the lower end of the thermoneutral zone and the onset of heat production by brown adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Since trauma also impairs shivering thermogenesis (Stoner, 1971(Stoner, , 1972 this failure of non-shivering thermogenesis cannot be replaced by shivering so that the results are important for small mammals and the neonates of larger species, including man. Taking these results with previous ones (Stoner, 1969(Stoner, , 1971(Stoner, , 1972Stoner & Marshall, 1971) the overall effects of limb ischaemia on thermoregulation in the rat before the stage of necrobiosis can be summarized as follows.…”

Section: Discussionmentioning

confidence: 99%

“…3). Since it is unlikely that the hypothalamus is wrongly informed of the rat's environment (Stoner, 1971(Stoner, , 1972, the main question is whether or not this effect is due to peripheral or central changes. Heat production in brown adipose tissue is very sensitive to 02 lack (Heim & Hull, 1966a).…”

Section: Discussionmentioning

confidence: 99%

“…The experiments were carried out 2-6 days (mean 4) after the operation in the environmental chamber described previously (Stoner, 1971). The temperature of the air (Ta) in the chamber was measured with a thermocouple.…”

Section: Methodsmentioning

confidence: 99%

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Inhibition of thermoregulatory non‐shivering thermo‐genesis by trauma in cold‐acclimated rats

Stoner¹

1974

The Journal of Physiology

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1. Heat production and blood flow in the interscapular brown adipose tissue of 3° C acclimated rats have been measured by the heated thermo‐couple technique. 2. When the environmental temperature (Ta) was reduced from 30 to 3° C heat production by the brown adipose tissue began to increase at the lower limit of the thermoneutral zone and then increased linearly. 3. Blood flow also increased when Ta was reduced but was not so well correlated with Ta. There was however a good positive correlation between blood flow and heat production. 4. During the first hour after a 4 hr period of bilateral hind‐limb ischaemia in a 20° C environment the percentage of rats not producing heat in the interscapular brown adipose tissue increased and the tissue blood flow fell. 5. By varying the Ta of the injured rat it was found that the Ta at which heat transfer from the interscapular brown adipose tissue commenced was significantly lower than in the controls although the slope of the regression lines relating heat production and Ta was unaltered. 6. Blood flow also increased in the injured rat when Ta was lowered but the increase in the tissue blood flow per unit increase in heat production was less than in the controls. 7. In a 5° C environment heat production in the interscapular brown adipose tissue of the injured rat was further increased by the S. C. injection of L‐isoprenaline or L‐noradrenaline. 8. It is concluded that the central control of thermoregulatory non‐shivering thermogenesis is inhibited after injury in the rat.

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Section: Resultsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%