Effect of Inoculum Size and Length of Infection on the Distribution of Toxocara canis Larvae in the Mouse *

Kayes, Stephen G.; Oaks, John A.

doi:10.4269/ajtmh.1976.25.573

Cited by 36 publications

(21 citation statements)

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“…In this situation, we anticipated a more heightened and sustained host immune reaction to secondary and subsequent infections of the parasite (44)(45)(46)(47)(48)(49)(50). Prior work had noted that the pattern of larval distribution in various organ systems is different in rodents given single versus multiple doses of T. canis (51)(52)(53). Our data supported the notion that prior exposure could indeed protect the organisms against subsequent exposures to T. canis.…”

Section: Immunological Considerationsupporting

confidence: 78%

The Consequences of Parasitic Infection for the Behavior of the Mammalian Host

Donovick¹,

Burright²

1987

Environmental Health Perspectives

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Section: Immunological Considerationsupporting

confidence: 78%

The Consequences of Parasitic Infection for the Behavior of the Mammalian Host

Donovick¹,

Burright²

1987

Environmental Health Perspectives

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“…It increases over the course of infection and the final larval count is influenced also by host immune status (Kayes and Oaks 1976, Abo-Shehada et al 1991, Othman et al 2010. With progress of the primary infection, we noted increasing accumulation of larvae in the mouse brain similarly as it was reported in many studies (Sprent 1955;Dunsmore et al 1983;Bardón et al 1994, Table 4 The mean number (±SD) of T. canis larvae in the mouse eyes detected by DT and histology during various intervals post primary infection (PPI) and reinfection (PR) and the number of animals with unilateral (UNILAT) and bilateral (BILAT) infections Skerrett and Holland 1997;Cox and Holland 2001a, b;Good et al 2001;Hamilton et al 2006;Camparoto et al 2008;Othman et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS

et al. 2011

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Using a small animal imaging system, migratory activity of Toxocara canis larvae stained by carboxyfluorescein succinimidyl ester (CFSE) was observed post primary infection (PPI) and post reinfection (PR) of BALB/c mice. Each infection was performed with 1,000 larvae per mouse. Primary infections were performed with labeled larvae, while for challenge infections the reinfecting larvae were stained by CFSE. The worm burden in mouse organs was determined during a period from 6 h to 21 days and 4 months PPI and PR. In comparison with primary infections that led to the first larvae appearance in the brain after 60 h, greatly accelerated migration of the parasites administered 3 weeks PPI to the CNS and eyes of challenged mice was noted-in both organs the larvae appeared 6 h PR. In all challenged mice, reinfecting larvae prevailed in the resident parasite population. Preliminary experiments with Toxocara cati larvae also revealed early brain involvement in primarily infected mice. Staining of T. canis larvae by CFSE had no effect on the development of a humoral antibody response against T. canis excretory-secretory antigens. In ELISA, elevated levels of specific IgG and IgG1 were noted on day 14 PPI and the levels of antibodies increased till the end of experiment. Reinfection induced an increase in the levels of both antibodies. In terms of optical density, IgG1 antibodies gave higher values in all sera examined. In ELISA for IgG antibodies, an increase in the avidity index of around 50% was detected 1 month PPI; higher-avidity antibodies were also detected in sera of reinfected animals.

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“…T. canis larvae have already reached the lungs and by 20 days p.i. the number of larvae decreases [14], although they do not disappear completely because previous studies have shown a small number of larvae still present in the lungs of BALB/c mice at 60 days p.i. [12].…”

Section: Discussionmentioning

confidence: 99%

Infection with the roundworm Toxocara canis leads to exacerbation of experimental allergic airway inflammation

Pinelli¹,

Brandes²,

Dormans³

et al. 2007

Clin Experimental Allergy

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A previous infection with T. canis leads to exacerbation of experimental allergic airway inflammation. These results have important consequences for findings on the helminths-allergy association. Several factors, including parasite species, infection of definitive vs. accidental host, parasite load and timing of infection, may influence whether an infection with helminths protects one from or enhances allergic manifestations.

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Effect of Inoculum Size and Length of Infection on the Distribution of Toxocara canis Larvae in the Mouse *

Cited by 36 publications

References 0 publications

The Consequences of Parasitic Infection for the Behavior of the Mammalian Host

The Consequences of Parasitic Infection for the Behavior of the Mammalian Host

Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS

Infection with the roundworm Toxocara canis leads to exacerbation of experimental allergic airway inflammation

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