Effect of inorganic salts, amino acids and proteins on the degradation of pure magnesium in vitro

Yamamoto, Akiko; Hiromoto, Sachiko

doi:10.1016/j.msec.2008.12.015

Cited by 337 publications

(234 citation statements)

References 23 publications

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“…Table 5 presents the composition of the solutions used by Yamamoto [76]. In this study, it was claimed that E-MEM+FBS contained approximately half the wt% proteins compared to blood plasma [76]. However, this does not appear to be the case, as the protein concentrations presented in Table 5 suggest that E-MEM +FBS contained less than 10% of the proteins present in blood Plasma.…”

Section: Proteinsmentioning

confidence: 85%

“…A further study by Liu et al [81] on Mg-1.5Ca in NaCl solutions containing albumin found that the presence of proteins increased the charge transfer resistance of the corrosion layer on the surface of the Mg sample, and substantially decreased the corrosion rate as measured by hydrogen evolution. Yamamoto et al [76] also found that the addition of protein moderately retarded the corrosion of pure Mg. Zhang et al [84] found the addition of 10% protein to a SBF slightly decreased the corrosion rate of a Mg-Nd-Zn-Zr alloy, while the addition of 1% HUVEC (human umbilical vein endothelial cells) slightly increased it. SEM analysis indicated C and N peaks, and appeared to indicate incorporation of proteins into the corrosion product layer [84].…”

Section: Proteinsmentioning

confidence: 95%

Section: Proteinsmentioning

confidence: 95%

“…This is significant as the (Mg, Ca)-P corrosion layers have been identified in in vivo studies [50]. Yamamoto et al [76] considered the solubility limits of phosphate ions in EBSS to determine that Ca-P precipitation should be preferential in this solution at higher pH or when other nucleation opportunities present. These findings were supported by EDX analysis, which found Ca and P incorporated into the corrosion product layer.…”

Section: Phosphate Ions (H 2 Pomentioning

confidence: 99%

“…Amino acids in particular have gathered interest in biocorrosion studies [76], presumably because of their presence in certain SBFs such as MEM as shown in Table 1. These additional components, such as amino acids, are at much lower concentrations in blood compared to proteins [79,89].…”

Section: Amino Acids Vitamins and Other Nutrientsmentioning

confidence: 99%

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Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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Section: Proteinsmentioning

confidence: 85%