Effect of inositol stereoisomers at different dosages in gestational diabetes: an open-label, parallel, randomized controlled trial

Fraticelli, Federica; Celentano, Claudio; I, Zecca; Vieste, Giacoma Di; Pintaudi, Basilio; Liberati, Marco; Franzago, Marica; Nicola, Marta Di; Vitacolonna, Ester

doi:10.1007/s00592-018-1157-4

Cited by 36 publications

(39 citation statements)

References 29 publications

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“…As mentioned above, supplementation with DCI alone (250 mg of DCI plus 200 μg FA, twice a day) or associated with Myo (Myo 550 mg/DCI 13.8 mg/FA 200 μg twice a day) in women with GDM did not produce a significant effect on insulin sensitivity . However, in women requiring insulin therapy, supplementation with both Myo or Myo/DCI was associated with less need to up‐titrate insulin …”

Section: Clinical Effects Of Myo/dci Association Supplementationmentioning

confidence: 90%

“…However, these dosages are not currently allowed for supplementation. Furthermore, no side effects were observed in patients receiving intervention with DCI (27.5 up 500 mg/day) in the clinical studies available …”

Section: Inositol Safetymentioning

confidence: 92%

“…Fraticelli et al recently conducted in pregnant women affected by GDM an open‐label, parallel, randomized, controlled trial to compare the effects of 8 weeks of treatment with different dosages and combinations of inositol stereoisomers on insulin resistance (assessed by HOMA‐IR) and several maternal‐foetal outcomes. Women affected by GDM treated with Myo (4000 mg) showed a significant amelioration in insulin resistance and a lower variation in average weight gain during pregnancy as compared with DCI (500 mg) and to Myo/DCI (1100 mg/27.6 mg).…”

Section: Clinical Effects Of Myo‐inositol Supplementationmentioning

confidence: 99%

“…Women affected by GDM treated with Myo (4000 mg) showed a significant amelioration in insulin resistance and a lower variation in average weight gain during pregnancy as compared with DCI (500 mg) and to Myo/DCI (1100 mg/27.6 mg). Moreover, women exposed to Myo and Myo plus DCI required a significantly lower necessity of an intensified insulin treatment …”

Section: Clinical Effects Of Myo‐inositol Supplementationmentioning

confidence: 99%

“…Opposite data were obtained in a study comparing different inositol stereoisomers in GDM women where insulin sensitivity was not affected by treatment with 250 mg of DCI plus 200 μg FA, twice a day . In addition, in a randomized controlled trial, Celentano et al used different inositol stereoisomers in order to investigate their ability to prevent GDM in high‐risk women and obtained the largest benefit with Myo supplementation, as compared with supplementation with DCI or with Myo/DCI.…”

Section: Clincal Effects Of D‐chiro‐inositol Supplementationmentioning

confidence: 99%

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Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Formoso

Baldassarre

Ginestra

et al. 2019

Diabetes Metabolism Res

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Summary Pregnancies complicated by diabetes have largely increased in number over the last 50 years. Pregnancy is characterized by a physiologic increase in insulin resistance, which, associated with increased oxidative stress and inflammations, could induce alterations of glucose metabolism and diabetes. If not optimally controlled, these conditions have a negative impact on maternal and foetal outcomes. To date, one can resort only to diet and lifestyle to treat obesity and insulin resistance during pregnancy, and insulin remains the only therapeutic option to manage diabetes during pregnancy. However, in the last years, in a variety of experimental models, inositol and antioxidants supplementation have shown insulin‐sensitizing, anti‐inflammatory, and antioxidant properties, which could be mediated by some possible complementary mechanism of action. Different isomers and multiple combinations of these compounds are presently available: Aim of the present review article is to examine the existing evidence in order to clarify and/or define the effects of different inositol‐ and antioxidant‐based supplements during pregnancy complicated by insulin resistance and/or by diabetes. This could help the clinician's evaluation and choice of the appropriate supplementation regimen.

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Section: Clinical Effects Of Myo/dci Association Supplementationmentioning

confidence: 90%

Section: Inositol Safetymentioning

confidence: 92%

Section: Clinical Effects Of Myo‐inositol Supplementationmentioning

confidence: 99%

Section: Clinical Effects Of Myo‐inositol Supplementationmentioning

confidence: 99%

Section: Clincal Effects Of D‐chiro‐inositol Supplementationmentioning

confidence: 99%

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Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Formoso

Baldassarre

Ginestra

et al. 2019

Diabetes Metabolism Res

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Inositol supplementation for the prevention and treatment of gestational diabetes mellitus: a meta-analysis of randomized controlled trials

Shi

2023

Arch Gynecol Obstet

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Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

Pinto

Croce

Carlier

et al. 2023

J Endocrinol Invest

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Purpose Gestational diabetes mellitus (GDM) and thyroid dysfunction during gestation (GTD) are the two most prevalent endocrinopathies during pregnancy. The aim of the present review is to provide an overview of the peculiar aspects of GDM and GTD, to highlight the potential interactions and clinical consequences of these two frequent clinical conditions. Methods A literature review regarding GDM and GTD was carried out with particular interest on meta-analyses and human studies dealing with the (i) shared risk factors between GDM and GTD, (ii) the epidemiological link between GTD and GDM, (iii) physiopathologic link between GTD and GDM, (iv) clinical consequences of GDM and GTD, and (v) post-partum implications of GDM and GTD. Results The association between GDM and GTD is common and may be explained by the insulin-resistance state due to maternal GTD, to alterations in the placentation process or to the many shared risk factors. Discrepant results of epidemiologic studies can be explained, at least in part, by the changes in diagnostic criteria and screening strategies throughout the years for both conditions. GDM and GTD impact pregnancy outcome and have post-partum long-term consequences, but more studies are needed to prove an additional adverse effect. Conclusions Based on the epidemiological and physio-pathological link between GDM and GTD, it could be suggested that a diagnosis of GTD could lead to screen GDM and the other way round.

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Effect of inositol stereoisomers at different dosages in gestational diabetes: an open-label, parallel, randomized controlled trial

Cited by 36 publications

References 29 publications

Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Inositol supplementation for the prevention and treatment of gestational diabetes mellitus: a meta-analysis of randomized controlled trials

Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

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