Effect of insomnia treatments on depression: A systematic review and meta-analysis

Gebara, Marie Anne; Siripong, Nalyn; DiNapoli, Elizabeth A.; Maree, Rachel D.; Germain, Anne; Reynolds, Charles F.; Kasckow, John; Weiss, Patricia M; Karp, Jordan F.

doi:10.1002/da.22776

Cited by 181 publications

(120 citation statements)

References 74 publications

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“…To the best of our knowledge, this is the first pilot study exploring the genetic contribution of the APLN/APLNR pathway to the susceptibility to depression and anxiety in Chinese patients with CHD. We first found that patients with CHD who experienced insomnia had a high risk of comorbid depression and anxiety, which was consistent with previous findings, demonstrating that insomnia is frequently co-morbid with depression and anxiety (Gebara et al, 2018). Additionally, patients with CHD who has alcohol drinking habits were less likely to have FIGURE 2 | Association of apelin receptor (APLNR) rs9943582 polymorphism with PHQ-9 scores in coronary heart disease (CHD) patients with comorbid depression.…”

Section: Discussionsupporting

confidence: 88%

Association of Apelin and Apelin Receptor Polymorphisms With the Risk of Comorbid Depression and Anxiety in Coronary Heart Disease Patients

Wang

Liu

et al. 2020

Front. Genet.

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The Apelin (APLN)/apelin receptor (APLNR) signaling pathway is a newly identified regulator in various cardiovascular diseases, which is considered as a candidate pathway for the occurrence of coronary heart disease (CHD), depression, and anxiety. The goal of this study was to investigate the association between APLN/APLNR gene polymorphisms and the risk of depression and anxiety in CHD patients. To this end, a case-control study involving 269 CHD patients and 184 healthy control individuals was conducted. The 269 patients with CHD including 122 patients with and 147 patients without depression, and 56 patients with and 213 patients without anxiety Four single nucleotide polymorphisms were selected and successfully genotyped using Sanger sequencing. The APLN rs2235310T allele and APLNR rs9943582C allele were found to be associated with an increased risk of CHD after multiple test correction (Padjust < 0.05). The patients with CHD who carried the rs9943582C allele had a higher risk of depression, after adjusting for alcohol drinking habits, insomnia, hypertension, and stroke history, with the Bonferroni correction (P-adjust = 0.018). The APLNR rs2282623 T allele was associated with an increased risk of anxiety in CHD patients after adjusting for related disease complications, with the Bonferroni correction (Padjust = 0.022). We reported for the first time that the APLN rs2235310 and APLNR rs2282623 polymorphisms are associated with the risks of psychiatric disorders in CHD patients and may serve as novel biomarkers for therapy.

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Section: Discussionsupporting

confidence: 88%

Association of Apelin and Apelin Receptor Polymorphisms With the Risk of Comorbid Depression and Anxiety in Coronary Heart Disease Patients

Wang

Liu

et al. 2020

Front. Genet.

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“…Furthermore, meta-analyses of RCTs also support the efficacy of sleep interventions in reducing symptoms of depression. Of note, whereas many trials have shown the alleviation of subclinical depressive symptoms following sleep interventions, the available evidence suggests that even larger effects of sleep therapies on depression are observed in those with mental illness [79][80][81]94 . Additionally, a role of poor sleep in severe mental disorders is suggested by a recent RCT showing that CBT for insomnia (CBT-I) significantly reduces the severity of hallucinations and para-noia in youth experiencing symptoms of psychosis 95 .…”

Section: Discussionmentioning

confidence: 99%

A meta‐review of “lifestyle psychiatry”: the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders

et al. 2020

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There is increasing academic and clinical interest in how “lifestyle factors” traditionally associated with physical health may also relate to mental health and psychological well‐being. In response, international and national health bodies are producing guidelines to address health behaviors in the prevention and treatment of mental illness. However, the current evidence for the causal role of lifestyle factors in the onset and prognosis of mental disorders is unclear. We performed a systematic meta‐review of the top‐tier evidence examining how physical activity, sleep, dietary patterns and tobacco smoking impact on the risk and treatment outcomes across a range of mental disorders. Results from 29 meta‐analyses of prospective/cohort studies, 12 Mendelian randomization studies, two meta‐reviews, and two meta‐analyses of randomized controlled trials were synthesized to generate overviews of the evidence for targeting each of the specific lifestyle factors in the prevention and treatment of depression, anxiety and stress‐related disorders, schizophrenia, bipolar disorder, and attention‐deficit/hyperactivity disorder. Standout findings include: a) convergent evidence indicating the use of physical activity in primary prevention and clinical treatment across a spectrum of mental disorders; b) emerging evidence implicating tobacco smoking as a causal factor in onset of both common and severe mental illness; c) the need to clearly establish causal relations between dietary patterns and risk of mental illness, and how diet should be best addressed within mental health care; and d) poor sleep as a risk factor for mental illness, although with further research required to understand the complex, bidirectional relations and the benefits of non‐pharmacological sleep‐focused interventions. The potentially shared neurobiological pathways between multiple lifestyle factors and mental health are discussed, along with directions for future research, and recommendations for the implementation of these findings at public health and clinical service levels.

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“…Importantly, interventions on insomnia also ameliorate depressive symptoms (44, 46, 47, 84, 247, 399) (for meta-analysis, see (139)). While it has been demonstrated that insomnia is indeed an independent risk factor contributing to first onset depression (43), a six month insomnia intervention follow-up was insufficiently sensitive to find differences between treatment and placebo with respect to the incidence of new onset major depressive disorder (84).…”

Section: Mental Health Risks Conveyed By Insomniamentioning

confidence: 99%

Brain mechanisms of insomnia: new perspectives on causes and consequences

Someren

2021

Physiological Reviews

284

179

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While insomnia is the second most common mental disorder, progress in our understanding of underlying neurobiological mechanisms has been limited. The present review addresses the definition and prevalence of insomnia and explores its subjective and objective characteristics across the 24-hour day. Subsequently, the review extensively addresses how the vulnerability to develop insomnia is affected by gene variants, early life stress and major life events and brain structure and function. Further supported by the clear mental health risks conveyed by insomnia, the integrated findings suggest that the vulnerability to develop insomnia could rather be found in brain circuits regulating emotion and arousal than in circuits involved in circadian and homeostatic sleep regulation. Finally, a testable model is presented. The model proposes that in people with a vulnerability to develop insomnia, the locus coeruleus is more sensitive to - or receives more input from - the salience network and related circuits, even during REM sleep, when it should normally be sound asleep. This vulnerability may ignite a downwards spiral of insufficient overnight adaptation to distress, resulting in accumulating hyperarousal which in turn impedes restful sleep and moreover increases the risk of other mental health adversity. Sensitized brain circuits are likely to be subjectively experienced as "sleeping with one eye open". The proposed model opens up the possibility for novel intervention studies and animal studies, thus accelerating the ignition of a neuroscience of insomnia, which is direly needed for better treatment.

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Effect of insomnia treatments on depression: A systematic review and meta-analysis

Cited by 181 publications

References 74 publications

Association of Apelin and Apelin Receptor Polymorphisms With the Risk of Comorbid Depression and Anxiety in Coronary Heart Disease Patients

Association of Apelin and Apelin Receptor Polymorphisms With the Risk of Comorbid Depression and Anxiety in Coronary Heart Disease Patients

A meta‐review of “lifestyle psychiatry”: the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders

Brain mechanisms of insomnia: new perspectives on causes and consequences

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