Background: Respiratory muscle weakness is one of the primary factors associated with difficulty of ventilatory weaning in critically ill patients. In this sense, inspiratory muscle training (IMT) is a possible facilitator of successful weaning. One of the devices used for IMT is the POWERbreathe®, because it provides a linear pressure load, with the possibility of gradual increments. The effectiveness of early IMT in this population is not yet well known. The aim of this study is to assess the effects of early IMT with a mechanical loading device on the weaning time of patients on invasive mechanical ventilation (primary outcome), respiratory muscle strength, length of stay in the intensive care unit and in the success rate of weaning (secondary outcomes).Methods: This randomised controlled trial, a single blind evaluation, will be conducted in the intensive care unit of a university hospital on 42 adults, who will be randomly and blindly categorised into the control group, comprising patients who undergo routine physical therapy only, and the training group, comprising patients who undergo routine physical therapy associated with IMT twice a day, with load adjusted daily at 50% of maximum inspiratory pressure, three series of 10 repetitions with one minute rest in between. Both groups will be assessed when patients are eligible for the study and before the ventilatory support withdrawal. Effects of the training will be analysed from the collected data using intention-to-treat analysis. Between-group differences will be measured using generalised estimating equations for data analysis.Discussion: Results of this trial will likely provide valuable new information on the effects of IMT on weaning time, respiratory muscle strength, length of stay in the intensive care unit and the success rate of weaning in critically ill patients.Registration: ClinicalTrials.gov, NCT03758573. 29th November 2018.