Effect of Insulin, Adrenal Cortical Hormones, Salt and dl-Alanine on Carbohydrate Metabolism in Scurvy.

Murray, Hazel C.

doi:10.3181/00379727-69-16716

Cited by 10 publications

(2 citation statements)

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“…Here, we report a large-scale omnidirectionally stretchable piezoelectric biocrystal network self-assembled from DL-alanine amino acid. Different from synthetic piezoelectric biomaterials obtained by complex chemical reactions (e.g., Poly-l-lactic Acid (PLLA) 35,36 ), DLalanine is a naturally occurring substance with excellent abundancy and sustainability and is involved in metabolism of many biological processes 37,38 . It possesses a superior piezoelectric response among akin biomaterials 39,40 .…”

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confidence: 99%

Stretchable piezoelectric biocrystal thin films

Li,

Carlos,

Zhou

et al. 2023

Nat Commun

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Stretchability is an essential property for wearable devices to match varying strains when interfacing with soft tissues or organs. While piezoelectricity has broad application potentials as tactile sensors, artificial skins, or nanogenerators, enabling tissue-comparable stretchability is a main roadblock due to the intrinsic rigidity and hardness of the crystalline phase. Here, an amino acid-based piezoelectric biocrystal thin film that offers tissue-compatible omnidirectional stretchability with unimpaired piezoelectricity is reported. The stretchability was enabled by a truss-like microstructure that was self-assembled under controlled molecule-solvent interaction and interface tension. Through the open and close of truss meshes, this large scale biocrystal microstructure was able to endure up to 40% tensile strain along different directions while retained both structural integrity and piezoelectric performance. Built on this structure, a tissue-compatible stretchable piezoelectric nanogenerator was developed, which could conform to various tissue surfaces, and exhibited stable functions under multidimensional large strains. In this work, we presented a promising solution that integrates piezoelectricity, stretchability and biocompatibility in one material system, a critical step toward tissue-compatible biomedical devices.

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confidence: 99%

Stretchable piezoelectric biocrystal thin films

Li,

Carlos,

Zhou

et al. 2023

Nat Commun

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“…Banerjee et al (48) suggested that the diminished insulin secretion in scorbutic guinea pigs may be the result of the combined effect of diminished glutathione content and increased dehydroascorbic-acid content of the tissues in general, and the pancreas in particular. Murray (49) added the observation that the injection of insulin or adrenocortical extract into scorbutic guinea pigs did not significantly alter the pathologic carbohydrate metabolic pattern. It is obvious, from this brief literature review, that the mechanism or mechanisms accounting for the change in carbohydrate metabolism have not yet been clarified.…”

Section: Discussionmentioning

confidence: 98%

Ascorbic Acid and Carbohydrate Metabolism. I. The Cortisone Glucose Tolerance Test

Setyaadmadja

Cheraskin

Ringsdorf

1965

J American Geriatrics Society

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Over the past quarter of a century, evidence has been accumulating from studies on lower animals (1-8) and humans (9-14) that there is a significant relationship between vitamin C and carbohydrate metabolism. Representative of published data is the observation that a progressive and significant decrease in glucose tolerance parallels the successive stages of vitamin-C depletion in guinea-pigs (1-2) (Fig. 1).The purpose of this report is to investigate whether in the human organism, a significant parallelism exists between cortisone glucose tolerance values and plasma ascorbic acid concentration. MATERIAL AND METHODSOne hundred and sixty-nine presumably healthy persons, drawn at random, participated in this experiment. The age and sex distributions are summarized in Table 1.Most of the subjects were in the third age decade and the sample was predominantly female. Carbohydrate metabolism was studied in each subject by means of the cortisone gIucose tolerance test (15). The plasma vitamin-C level was measured simultaneously under fasting conditions by the Mindlin-Butler technique (16). Figure 2 portrays the cortisone glucose tolerance pattern for the entire sample of 169 subjects. Three points are worthy of mention: 1) the mean values were well within the excepted physiologic limits, 2) the spread about the mean was least under fasting conditions (s.D. = 14.7) RESULTS Table 2 summarizes andand most a t one hour (s.D. = 44.4), and 3) on the basis of these means and standard deviations, it seems that some of the participants were prediabetic and others diabetic. Table 3 summarizes the plasma ascorbic-acid distribution for the entire group. There is still considerable controversy as to the physiologic range. The Interdepartmental Committee on Nutrition for National Defense (ICNND) argues that plasma ascorbic acid levels below 0.2 mg per 100 ml are unsatisfac- tory (17-19). If one accepts this cut-off point, then one most conclude from this survey that in 30.2 per cent of the participants the levels were too low. A few observers (20) prefer to regard 0.5 mg per 100 ml as the minimal acceptable level. On this basis, 55.0 per cent of the subjects in this survey had abnormal plasma concentrations. The majority of investigators favor a lower limit of 0.6

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