Effect of insulin on growth of cultured human arterial smooth muscle cells

Pfeifle, Beate; Ditschuneit, H

doi:10.1007/bf00262020

Cited by 215 publications

(82 citation statements)

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“…Similarly, some previous studies have shown an inverse association between insulin levels and arterial elasticity. 5,9,31 The mechanisms by which insulin level may effect arterial distensibility are not well elucidated but may include the effects of insulin, promoting vascular wall smooth muscle hypertrophy 37 and collagen tissue synthesis.…”

Section: Discussionmentioning

confidence: 99%

Large-Artery Elastic Properties in Young Men

Toikka

Niemi

Ahotupa

et al. 1999

ATVB

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Abstract-Measures of arterial elasticity have been proposed as surrogate markers for asymptomatic atherosclerosis. We investigated the relations of serum lipoproteins, oxidized low-density lipoprotein (ox-LDL), and familial hypercholesterolemia (FH) to arterial elasticity among young men. As a marker of arterial elasticity we measured compliance in the thoracic aorta by using magnetic resonance imaging and in the common carotid artery by using ultrasound. LDL diene conjugation was used as a marker of ox-LDL. In study I, 25 healthy men (aged 29 to 39) were classified into 2 extreme groups according to previously measured high-density lipoprotein cholesterol to total cholesterol ratio (HDL-C/TC ratio). In study II, the healthy men were used as controls for 10 age matched asymptomatic patients with FH. In healthy men, the group with low HDL-C/TC ratio had decreased carotid artery compliance (2.3Ϯ0.4% versus 1.9Ϯ0.5%/ 10 mm Hg, Pϭ0.034). In univariate analysis, the compliance of the carotid artery associated with ox-LDL (r ϭϪ0.49, Pϭ0.016) and HDL-C/TC ratio (rϭ0.41, Pϭ0.040). In multivariate regression analyses, ox-LDL was the only independent determinant for compliance of the carotid artery (Pϭ0.016). Aortic elasticity was not related to standard lipid variables, but the compliance of the ascending aorta associated with ox-LDL (rϭϪ0.44, Pϭ0.030). In FH patients, arterial elasticity was similar to that in controls. We conclude that elasticity of the common carotid artery is affected by serum lipid profile in young men. The current study demonstrates for the first time an in vivo association between ox-LDL and arterial elasticity suggesting that oxidative modification of LDL may play a role in the alteration of arterial wall elastic properties.

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Section: Discussionmentioning

confidence: 99%

Large-Artery Elastic Properties in Young Men

Toikka

Niemi

Ahotupa

et al. 1999

ATVB

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“…It is conceivable that chronic hyperinsulinaemia might induce vasoconstrictor responses since insulin stimulates vascular smooth muscle cell growth in animals and man [49,50]. Therefore, an insulin-induced structural change in resistance vessels may be responsible for increased peripheral resistance or lead to increased sensitivity to vasoconstrictor agonists.…”

Section: Discussionmentioning

confidence: 99%

The effect of insulin on the vascular reactivity of isolated resistance arteries taken from healthy volunteers

et al. 1995

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Summary Impaired reactivity of the resistance vasculature may contribute to the development of diabetic microangiopathy by altering microvascular haemodynamics. This study investigates the acute effects of insulin on the contractility and relaxation properties of isolated human resistance arteries (< 300 ~tm internal diameter) taken from gluteal subcutaneous fat of 33 (18 male: 15 female) normotensive healthy volunteers (supine blood pressure 115.6 + 1.6/ 70.0 + 1.5 mmHg [mean + SEM], with no family history of hypertension or diabetes mellitus. Resistance arteries were mounted in a small vessel myograph to measure isometric tension. Contractile responses to noradrenaline were reduced after incubation in 1 mU/ml of insulin for 20 min (p < 0.01; Group 1). Increasing concentrations of insulin were found to reduce the contractile response to noradrenaline in a dose-dependent manner (Group2; 0.1mU/ml by 8% [p

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“…t has been reported that hyperinsulinemia is an independent risk factor for ischemic heart disease (1) and induces greater vascular smooth muscle cell proliferation in experimental models (2,3). Insulin resistance with hyperinsulinemia is associated with hypertension, glucose intolerance, obesity, and dyslipoproteinemias of low HDL cholesterol levels or hypertriglyceridemias, which are wellknown risk factors for coronary artery disease (4 -6).…”

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confidence: 99%

A Randomized Comparison of Pioglitazone to Inhibit Restenosis After Coronary Stenting in Patients With Type 2 Diabetes

Nishio

2006

Diabetes Care

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OBJECTIVE -Recent studies have demonstrated that the treatment with thiazolidinediones reduces in-stent restenosis. The aim of this study was to elucidate the mechanism of the efficacy of pioglitazone for preventing in-stent restenosis in type 2 diabetic patients.RESEARCH DESIGN AND METHODS -We conducted a prospective, randomized trial involving 54 type 2 diabetic patients referred for coronary stenting who were randomly assigned to either the control or the pioglitazone group. Quantitative coronary angiography was performed at study entry and at 6 months follow-up. Endothelial nitric oxide synthase (eNOS), tumor necrosis factor ␣, interleukin-6, leptin, and adiponectin were measured at study entry and at 6 months follow-up.RESULTS -A total of 28 patients were randomly assigned to the control group, and 26 patients were assigned to the pioglitazone group. There were no significant differences in glycemic control levels or in lipid levels in the two groups at baseline or at follow-up. Insulin, homeostasis model assessment of insulin resistance, eNOS, and leptin at follow-up were significantly reduced in the pioglitazone group compared with the control group. The late luminal loss and in-stent restenosis were significantly less in the pioglitazone group than in the control group. Leptin independently correlated with late luminal loss at multiple regression analysis.CONCLUSIONS -The treatment with pioglitazone in type 2 diabetic patients significantly reduced leptin. This decreased leptin improved insulin resistance and endothelial function with the reduction of insulin. The improved endothelial function affected the reduction of in-stent restenosis. Diabetes Care 29:101-106, 2006I t has been reported that hyperinsulinemia is an independent risk factor for ischemic heart disease (1) and induces greater vascular smooth muscle cell proliferation in experimental models (2,3). Insulin resistance with hyperinsulinemia is associated with hypertension, glucose intolerance, obesity, and dyslipoproteinemias of low HDL cholesterol levels or hypertriglyceridemias, which are wellknown risk factors for coronary artery disease (4 -6).Recent studies showed that insulin resistance is an independent predictor of early restenosis after coronary stenting (7) and is associated with an increased incidence of myocardial infarction and death (8). Takagi and colleagues (9,10) demonstrated that troglitazone reduces neointimal tissue proliferation after coronary stent implantation, but pioglitazone does not reduce in-stent restenosis significantly. Donghoon et al. (11) showed that treatment with rosiglitazone significantly reduces in-stent restenosis. The efficacy of the thiazolidinediones (TZDs), which are novel insulin-sensitizing agents, against in-stent restenosis remains controversial.Endothelialization and endothelial function play an important role in coronary artery disease. Endothelial dysfunction has been considered a key element in the development of atherosclerosis and has also been found to be associated with insulin resistanc...

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Effect of insulin on growth of cultured human arterial smooth muscle cells

Cited by 215 publications

References 9 publications

Large-Artery Elastic Properties in Young Men

Large-Artery Elastic Properties in Young Men

The effect of insulin on the vascular reactivity of isolated resistance arteries taken from healthy volunteers

A Randomized Comparison of Pioglitazone to Inhibit Restenosis After Coronary Stenting in Patients With Type 2 Diabetes

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