Effect of insulin on plasma postheparin lipoprotein lipase activity in patients with coronary sclerosis and in control subjects

Orosz, László; Erdélyi, G; Romics, L; Gerö, S

doi:10.1016/0021-9150(73)90105-6

Cited by 8 publications

(1 citation statement)

References 27 publications

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“…Of interest are two recent reports in which low plasma testosterone was associated with impaired post-heparin lipoprotein lipase activity in patients with angiographically assessed coronary artery disease. 18 ' 17 Furthermore, plasma testosterone was positively correlated with plasma HDL cholesterol and negatively with plasma triglycerides. 17 In addition to the impaired lipoprotein lipase activity that was reported in patients with coronary artery disease, 1618 a positive association between lipoprotein lipase activity and plasma HDL cholesterol and a negative association between lipoprotein lipase and the severity of coronary artery disease have also been demonstrated.…”

Section: Discussionmentioning

confidence: 98%

Sex hormone levels in young Indian patients with myocardial infarction.

et al. 1986

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The finding of abnormal levels of sex hormones in men with coronary artery disease has led to the hypothesis that alterations in sex hormones may represent an important risk factor for myocardial infarction. In this study, the sex hormone profile of 28 young men (aged less than 40 years) with myocardial infarction was compared with 28 age- and weight-matched normal men. Although the mean total serum estradiol levels and the free estradiol index of the patients and controls were similar, the mean serum total testosterone level and the free testosterone index were significantly lowered in the patients with myocardial infarction (p less than 0.01). The ratio of serum estradiol to testosterone was significantly increased in the patients (p = 0.0005) and correlated with serum cholesterol, triglycerides, and plasma glucose. A significant inverse correlation was also demonstrated between total testosterone and serum cholesterol and triglycerides. Hence, the results of this study support the hypothesis that low plasma testosterone and an increased estradiol-to-testosterone ratio may be important risk factors for myocardial infarction.

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Section: Discussionmentioning

confidence: 98%

Sex hormone levels in young Indian patients with myocardial infarction.

et al. 1986

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Effects of prazosin and alphamethyldopa on blood lipids and lipoproteins in hypertensive patients

Velasco

Silva

Feldstein

et al. 1985

Eur J Clin Pharmacol

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The effects of prazosin and alphamethyldopa on blood lipids and lipoproteins were assessed in 20 patients with mild or moderate arterial hypertension. Parameters measured included serum cholesterol (CHO), triglycerides (TG), high density lipoprotein-cholesterol (HDL-CHO), insulin (I), glucose (G), and non-esterified fatty acids (NEFA). Prazosin -4 mg/day for 6 weeks in hydrochlorothiazide-treated patients lowered blood pressure by 18.6/17.2 (systolic/diastolic pressure) mmHg. There was a significant decrease in CHO (-5.8%), in I (-16.5%), and in NEFA (-3.0%), and a significant increase in HDL-CHO (+15.5%). Alphamethyldopa 250-750 mg/day for 6 weeks in hydrochlorothiazide-treated patients lowered blood pressure by 18.8/14.6 (systolic/diastolic pressure) mmHg, accompanied by a non-significant decrease in CHO and TG, and significant increases in HDL-CHO (+10.3%), G (+8.5%) and NEFA (+6.4%). Thus, prazosin appears to have a more beneficial effect on blood lipids and lipoproteins than alphamethyldopa.

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