Effect of intensity-modulated radiotherapy versus two-dimensional conventional radiotherapy alone in nasopharyngeal carcinoma

Ou-Yang, Pu; Shi, Dingbo; Sun, Rui; Zhu, Yu; Xiao, Yao; Zhang, Lu Ning; Zhang, Xu Hui; Chen, Ze Ying; Lan, Xiao Wen; Tang, Jie; Gao, Yuan; Ma, Jun; Deng, Wuguo; Xie, Fang

doi:10.18632/oncotarget.8573

Cited by 23 publications

(25 citation statements)

References 29 publications

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“…Due to the excellent dosimetric advantages for target coverage and normal tissue sparing by using IMRT, there were results showing signi cant improvement in treatment outcomes compared with 2D radiotherapy [2,3,9,21,23]. However, there were also some reports indicating that IMRT has no advantage over conventional 2D or 3D radiotherapy [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Treatment Outcomes of Patients with Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy

Yeh

Hwang

Wang

et al. 2020

Preprint

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Background: Nasopharyngeal cancer shows good response to intensity-modulated radiotherapy. However, there is no clear evidence for the benefits of routine application of image-guided radiotherapy. The purpose of this study was to perform a retrospective investigation of the treatment outcomes, treatment-related complications and prognostic factors for nasopharyngeal cancer treated with intensity-modulated radiotherapy and image-guided radiotherapy techniques.Methods: Retrospective analysis was carried out on 326 consecutive nasopharyngeal cancer patients treated between 2004 and 2015. Potentially significant patient-related and treatment-related variables were analyzed. Radiation-related complications were recorded.Results: The 5-year overall survival and disease-free survival rates of these patients were 77.9% and 70.5% respectively. Age, AJCC stage, retropharyngeal lymphadenopathy, treatment interruption, and Body Mass Index were independent prognostic factors for overall survival. Age, AJCC stage, retropharyngeal lymphadenopathy, image-guided radiotherapy, and Body Mass Index were independent prognostic factors for disease-free survival.Conclusion: Intensity-modulated radiotherapy significantly improves the treatment outcomes of nasopharyngeal cancer. With the aid of image-guided radiotherapy, the advantage of intensity-modulated radiotherapy might be further amplified.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Treatment Outcomes of Patients with Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy

Yeh

Hwang

Wang

et al. 2020

Preprint

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“…Intensity-modulated RT (IMRT) and VMAT provide superior target coverage, greater efficiency, fewer complications, shorter therapy duration, and less influence on the quality of life than do conventional RT and three-dimensional conformal RT ( Duarte et al, 2014 ; Lin et al, 2014 ; Tribius & Bergelt, 2011 ). IMRT and VMAT have rapidly replaced conventional RT and three-dimensional conformal RT since 2009 in Taiwan ( Bedford & Warrington, 2009 ; OuYang et al, 2016 ; Zhang et al, 2015 ). Therefore, the cutoff point in the present study was 2009.…”

Section: Discussionmentioning

confidence: 99%

Effects of income and residential area on survival of patients with head and neck cancers following radiotherapy: working age individuals in Taiwan

Lai

Tang

Chu

et al. 2018

PeerJ

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ObjectivesThe five-year survival rate of head and neck cancer (HNC) after radiotherapy (RT) varies widely from 35% to 89%. Many studies have addressed the effect of socioeconomic status and urban dwelling on the survival of HNC, but a limited number of studies have focused on the survival rate of HNC patients after RT.Materials and methodsDuring the period of 2000–2013, 40,985 working age individuals (20 < age < 65 years) with HNC patients treated with RT were included in this study from a registry of patients with catastrophic illnesses maintained by the Taiwan National Health Insurance Research Database (NHIRD).ResultsThe cumulative survival rate of HNC following RT in Taiwan was 53.2% (mean follow-up period, 3.75 ± 3.31 years). The combined effects of income and geographic effect on cumulative survival rates were as follows: high income group > medium income group > low income group and northern > central > southern > eastern Taiwan. Patients with moderate income levels had a 36.9% higher risk of mortality as compared with patients with high income levels (hazard ratio (HR) = 1.369; p < 0.001). Patients with low income levels had a 51.4% greater risk of mortality than patients with high income levels (HR = 1.514, p < 0.001).ConclusionIn Taiwan, income and residential area significantly affected the survival rate of HNC patients receiving RT. The highest income level group had the best survival rate, regardless of the geographic area. The difference in survival between the low and high income groups was still pronounced in more deprived areas.

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“…Salvage treatments (including intracavitary brachytherapy, surgery, and chemotherapy) were provided in the events of documented relapse or persistent disease when necessary. Details of the radiation therapeutic techniques used at the Cancer Center of Sun Yat-sen University have been previously described 12 - 14 .…”

Section: Methodsmentioning

confidence: 99%

Evaluation of 7th Edition of AJCC Staging System for Nasopharyngeal Carcinoma

et al. 2017

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Purpose: To evaluate and improve the 7th edition International Union against Cancer/American Joint Committee on Cancer staging system for nasopharyngeal carcinoma.Methods: A retrospective review of the data from 905 patients with biopsy-proven non-disseminated nasopharyngeal carcinoma was performed. All the patients were examined by magnetic resonance imaging (MRI) and received radiotherapy.Results: Satisfied distributions among the stages were observed in the 7th edition staging systems. LRFS only differed in classifications betweenT1 and T3, T1 and T4 (P=0.022 and P=0.016, respectively). Significant differences were observed between patients without and with masticator space involvement for OS, DMFS and PFS (p<0.05). No statistically significant differences in LRFS were observed among different groups with anatomical masticator space involvement. The DMFS between N2 and N3b, N3a and N3b were lack of significance (P=0.060 and P=0.59). The T category and N category were independent prognostic factors for the major endpoints in the Cox multivariate regression analysis (P<0.01).Conclusion: This study confirmed the prognostic value of the 7th edition UICC/AJCC staging system, the revisions of the 7th edition staging system are acceptable. However, our study also revealed limitations in the current staging system and suggested some potential modifications in future revision.

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Effect of intensity-modulated radiotherapy versus two-dimensional conventional radiotherapy alone in nasopharyngeal carcinoma

Cited by 23 publications

References 29 publications

WITHDRAWN: Treatment Outcomes of Patients with Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy

WITHDRAWN: Treatment Outcomes of Patients with Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy

Effects of income and residential area on survival of patients with head and neck cancers following radiotherapy: working age individuals in Taiwan

Evaluation of 7th Edition of AJCC Staging System for Nasopharyngeal Carcinoma

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