Effect of intensive glycaemic control on endothelial progenitor cells in patients with long-standing uncontrolled type 2 diabetes

Lev, Eli I.; Singer, Joel; Leshem-Lev, Dorit; Rigler, Merav; Dadush, Oshrat; Vaduganathan, Muthiah; Battler, Alexander; Kornowski, Ran

doi:10.1177/2047487313488300

Cited by 16 publications

(17 citation statements)

References 46 publications

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“…The correlation between changes in levels of EPCs and corresponding changes in the CIMT was assessed using Spearman's coefficients of correlation. Participants were divided into groups of low (scores of 0-3), middle (4-5) and high (6)(7)(8)(9) adherence to the Mediterranean diet based on their diet scores for analysis. Comparisons were conducted using linear regression to test for trends across the Mediterranean dietary pattern score groups for EPCs and CIMT.…”

Section: Discussionmentioning

confidence: 99%

“…6 A reduction in EPCs may represent one of the mechanisms linking increased vascular risk with diabetes mellitus. 7 The effect of a Mediterranean diet on circulating EPCs has never been investigated in patients with type 2 diabetes free of cardiovascular disease (CVD). Therefore, using the data from a randomized trial (MÈ DITA; MEditerranean DIet and Type 2 diAbetes), 8 we investigated (a) whether a Mediterranean diet affected circulating levels of EPCs in patients newly diagnosed with type 2 diabetes, (b) whether changes in circulating levels of EPCs were associated with changes in the carotid intima-media thickness (CIMT), considered to be a surrogate marker for CVD in patients with type 2 diabetes 9 and (c) whether the effect was sustained during long-term follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial

Maiorino

Bellastella

Petrizzo

et al. 2016

Eur J Prev Cardiolog

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We assessed the long-term effects of a Mediterranean diet on circulating levels of endothelial progenitor cells (EPCs) and the carotid intima-media thickness (CIMT) in patients with type 2 diabetes. Design: This was a parallel, two-arm, single-centre trial. Methods: Two hundred and fifteen men and women with newly diagnosed type 2 diabetes were randomized to a Mediterranean diet (n ¼ 108) or a low-fat diet (n ¼ 107). The primary outcome measures were changes in the EPC count and the CIMT of the common carotid artery after the treatment period defined as the end of trial (EOT). Results: At the EOT, both the CD34þ counts had increased with the Mediterranean diet compared with the low-fat diet (p < 0.05 for both). At the EOT evaluation, there was a significant (p ¼ 0.024) difference of À0.025 mm in the CIMT favouring the Mediterranean diet. Compared with the low-fat diet, the rate of regression in the CIMT was higher in the Mediterranean diet group (51 vs. 26%), whereas the rate of progression was lower (25 vs. 50%) (p ¼ 0.032 for both). Changes in the CIMT were inversely correlated with the changes in EPC levels (CD34At the EOT, changes in levels of HbA1c, HOMA, total cholesterol, high-density lipoprotein cholesterol and systolic blood pressure were significantly greater with the Mediterranean diet than with the low-fat diet. Conclusion: Compared with a low-fat diet, a long-term trial with Mediterranean diet was associated with an increase in circulating EPCs levels and prevention of the progression of subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial

Maiorino

Bellastella

Petrizzo

et al. 2016

Eur J Prev Cardiolog

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“…Previous studies displayed reduced levels of circulating EPCs with attenuated functional properties in patients with diabetes mellitus when compared to non-diabetics, and found that tight glycemic control improved their functional capabilities [12]. However, it is not known by which mechanisms diabetes mellitus affects these cells.…”

Section: Discussionmentioning

confidence: 99%

“…The circulating endothelial progenitor cells count has also been proposed as a surrogate marker of vascular dysfunction and is reduced in patients with various CV risk factors [3]. Furthermore, diabetes mellitus is known to have a deleterious effect on EPC function and level, and tight glycemic control was associated with an increase in EPCs levels and improvement in their functional properties [12]. …”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D on endothelial progenitor cells function

et al. 2017

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BackgroundEndothelial progenitor cells (EPCs) are a population of bone marrow-derived cells, which have an important role in the process of endothelialization and vascular repair following injury. Impairment of EPCs, which occurs in patients with diabetes, was shown to be related to endothelial dysfunction, coronary artery disease (CAD) and adverse clinical outcomes. Recent evidence has shown that calcitriol, the active hormone of vitamin D, has a favorable impact on the endothelium and cardiovascular system. There is limited data on the effect of vitamin D on EPCs function.AimTo examine the in vitro effects of Calcitriol on EPCs from healthy subjects and patients with diabetes.MethodsFifty-one patients with type 2 diabetes (60±11 years, 40% women, HbA1C: 9.1±0.8%) and 23 healthy volunteers were recruited. EPCs were isolated and cultured with and without calcitriol. The capacity of the cells to form colony-forming units (CFUs), their viability (measured by MTT assay), KLF-10 levels and angiogenic markers were evaluated after 1 week of culture.ResultsIn diabetic patients, EPC CFUs and cell viability were higher in EPCs exposed to calcitriol vs. EPCs not exposed to calcitriol [EPC CFUs: 1.25 (IQR 1.0–2.0) vs. 0.5 (IQR 0.5–1.9), p < 0.001; MTT:0.62 (IQR 0.44–0.93) vs. 0.52 (IQR 0.31–0.62), p = 0.001]. KLF-10 levels tended to be higher in EPCs exposed to vitamin D, with no differences in angiopoietic markers. In healthy subjects, calcitriol supplementation also resulted in higher cell viability [MTT: 0.23 (IQR 0.11–0.46) vs. 0.19 (0.09–0.39), p = 0.04], but without differences in CFU count or angiopoietic markers.ConclusionIn patients with diabetes mellitus, in vitro vitamin D supplementation improved EPCs capacity to form colonies and viability. Further studies regarding the mechanisms by which vitamin D exerts its effect are required.

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“…В исследовании Churdchomjan W. с соавт. продемонстрировано сниже-ние количества циркулирующих ЭПК у больных СД2 с неудовлетворительным контролем гликемии (уровень HbA 1c >7,0%) по сравнению с пациентами с удовлетвори-тельным контролем гликемии (уровень HbA 1c ≤7,0%) [24]. В двух последующих работах исследователи наблюдали динамику ЭПК в зависимости от интенсивности глике-мического контроля у больных СД2.…”

Section: сахарный диабет Diabetes Mellitusunclassified

Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes

Michurova¹,

Kalashnikov²,

Смирнова³

et al. 2017

Diabetes mellitus

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ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет), Москва Цель. Изучить количество эндотелиальных прогениторных клеток (ЭПК) и уровень сосудистого эндотелиального фактора роста (VEGF-A) после рентгенэндоваскулярных вмешательств на коронарных артериях и артериях ниж-них конечностей у пациентов с сахарным диабетом 2 типа (СД2 (p = 0.001 and 0.005, respectively). In patients

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Effect of intensive glycaemic control on endothelial progenitor cells in patients with long-standing uncontrolled type 2 diabetes

Abstract: In patients with uncontrolled long-standing type 2 diabetes, intensive glycaemic control was associated with an increase in the levels of circulating EPCs, and improvement in their functional properties.

Cited by 16 publications

References 46 publications

Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial

Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial

Effect of vitamin D on endothelial progenitor cells function

Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes

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