Effect of Interaction Between Duration of Alcohol Consumption and Alcohol Dependence on Thyroid Function Test: Cross Sectional Observational Study

Honnamurthy, Jogappanavar Basappa; Shivashankara, Arnadi Ramachandrayya; Avinash, S S; Mathai, Paul; Munisamy, Malathi

doi:10.1007/s12291-017-0645-6

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…in terms of thyroid cancer risk. Honnamurthy et al revealed a significant influence of alcohol consumption duration, but not alcohol dependence on thyroid function tests [17]. Whang et al report a reduction in thyroid cancer risk with decreased alcohol consumption (25 g or less)…”

Section: Discussionmentioning

confidence: 99%

Alcohol abuse as a risk factor for developing thyroid cancer

et al. 2021

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Introduction/Objective. Alcohol abuse influence on developing thyroid cancer is controversial. While some studies consider it a protective factor, others deny any impact on thyroid cancer. The objective of the paper was to establish a possible link between alcohol abuse and certain types of thyroid cancers. Methods. The retrospective study included 502 patients with thyroid cancer and control group of 600 patients with benign forms of thyroid diseases (e.g. nodular, multinodular and toxic nodular goiter). Thyroid cancer patients were divided into 4 groups: I - papillary, II - medullary, III - anaplastic, and IV - follicular carcinoma, and grouped by sex, age (< 30 yrs.; > 30 yrs.) and alcohol abuse, as defined by WHO. Results. Thyroid cancer patients were predominantly male of younger age. This distribution difference was statistically significant in groups I and II (p < 0.001). Of total 10 (0.9%) patients with chronic alcohol abuse, 8 (1.6%) had thyroid cancer, while 2 (0.3%) belonged to the control group (p < 0.001). In thyroid cancer patients, chronic alcohol abuse was absent in group III and IV. Distribution in group I and II was 6 (1.6%) and 2 (2%) respectively (p < 0.001). Conclusion. Alcohol abuse deserves to be considered as a risk factor for papillary and medullary forms of thyroid cancer, while it does not stay the same for anaplastic and follicular thyroid cancers.

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Section: Discussionmentioning

confidence: 99%

Alcohol abuse as a risk factor for developing thyroid cancer

et al. 2021

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“…Findings are however deviating [ 12 ]. Simultaneously, a decrease in FT4 has been described in patients with chronic alcohol use [ 15 – 18 ]. FT4 and TSH are linked.…”

Section: Discussionmentioning

confidence: 99%

FT4 and TSH, relation to diagnoses in an unselected psychiatric acute-ward population, and change during acute psychiatric admission

2018

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BackgroundAlteration in thyroid activity is a well-known cause of symptoms mimicking psychiatric disorders. There are reports on altered levels of thyroid hormones in patients with certain psychiatric disorders compared to healthy controls; still, the magnitude and importance of the phenomenon is not known. We wanted to explore the level of thyroid hormones in different diagnostic groups in an acute-psychiatric population. We also wanted to follow any change during their stay.MethodsPatients aged 18 years and older admitted to a closed, psychiatric inpatient ward were eligible if giving informed consent. For 539 patients representing all main psychiatric diagnostic groups and with equal gender distribution, data for FT4 were available for 539 patients, and data for TSH were available from 538 patients at admittance. For 239 patients, data for FT4 were available at both admittance and discharge, and the corresponding number for TSH was 236 patients.ResultsA significantly higher share of patients had higher levels of FT4 and TSH at admittance than expected for healthy individuals. No significant effect of gender or most diagnostic groups was seen.For female patients with substance-use disorder (SUD), the level of TSH was significantly lower than that for all other diagnostic groups. No other difference in the levels of FT4 and TSH was seen between the main diagnostic groups, and the effect in SUD was not seen in males.For the population with available markers at both admittance and discharge, in total, there was a significant reduction of FT4 from admittance to discharge, not followed by any change in TSH.ConclusionsIn acutely admitted psychiatric patients there seems to be an increased FT4 and TSH. FT4 is normalized during the inpatient stay independently of TSH. This indicates somatic effects of psychiatric stress that may be of clinical importance and the phenomenon should be further explored. Mainly different diagnostic groups did not differ in level of FT4 and TSH. Thus future studies on thyroid activity in psychiatric patients should focus on function and level of stress and suffering rather than diagnostic groups.Electronic supplementary materialThe online version of this article (10.1186/s12888-018-1819-3) contains supplementary material, which is available to authorized users.

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Bidirectional negative relationship between thyrotropin and kidney function during alcohol intoxication in males

Unlu,

Yehia,

Manji

et al. 2024

Front. Nephrol.

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IntroductionDespite a well-established direct toxic effect of alcohol on renal cells, there is a salutary dose-dependent effect of alcohol consumption on common laboratory parameters related to kidney performance. Alcohol also impacts thyroid hormones, while thyroid status modulates kidney function. The modulation of kidney parameters with thyrotropin (TSH) and thyroid status indicates a possible interaction between alcohol, kidney, and thyroid functions. This retrospective study was conducted to test the hypothesis that the positive effect of alcohol use on the estimated glomerular filtration rate (eGFR) is mediated by alcohol’s effect on thyroid hormones.MethodsWe reviewed the electronic medical records of 767 hospitalized adult patients free of thyroid disorders who received medical care in the Mayo Clinic Health System from June 2019 through June 2022 and had blood alcohol concentration (BAC), serum TSH, and serum creatinine measured during the hospitalization. We calculated the eGFR using both the re-expressed Modification of Diet in Renal Disease (MDRD II) study equation and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Creatinine equation.ResultsWe found a significant relationship of BAC with eGFR (CKD-EPI) and TSH in males only. BAC had a positive association with eGFR (b = 0.24, p = 0.0001) and negative with TSH (b=-0.17, p = 0.006). The covariance between the two outcomes (eGFR and TSH) was negative (b = -0.12, p = 0.049). The path analyses using the eGFR MDRD II equation were not significant in males, whereas females had no significant path analyses with either of the eGFR equations.DiscussionWe observed that BAC influences both eGFR and TSH, whereas eGFR and TSH influence each other. After considering important covariates (e.g., age, body mass index, diabetes mellitus, cardiovascular disease, chronic kidney disease, and chronic liver disease) and the negative bidirectional effect of TSH and eGFR, a positive impact of BAC on eGFR was observed in males.

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Effect of Interaction Between Duration of Alcohol Consumption and Alcohol Dependence on Thyroid Function Test: Cross Sectional Observational Study

Cited by 3 publications

References 27 publications

Alcohol abuse as a risk factor for developing thyroid cancer

Alcohol abuse as a risk factor for developing thyroid cancer

FT4 and TSH, relation to diagnoses in an unselected psychiatric acute-ward population, and change during acute psychiatric admission

Bidirectional negative relationship between thyrotropin and kidney function during alcohol intoxication in males

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